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(American Journal of Pathology. 1999;155:1261-1269.)
© 1999 American Society for Investigative Pathology

Regular Articles

The PEN5 Epitope Identifies an Oligodendrocyte Precursor Cell Population and Pilocytic Astrocytomas

Dominique Figarella-Branger^*, Laurent Daniel^*, Pascale André, Sophie Guia, Wanda Renaud^*, Gilberte Monti, Eric Vivier^§¶ and Geneviève Rougon

From the Laboratoire de Biopathologie Nerveuse et Musculaire,^*
IBDM–Faculté de Médecine Timone; the Service d'Hématologie,^§
Hôpital de la Conception; the Centre d'Immunologie,
UMR INSERM-CNRS 145; the Laboratoire de Génétique et de Physiologie du Développement,
UMR 6545 CNRS, IBDM, Parc Scientifique de Luminy; and the Institut Universitaire de France,^¶
Marseilles, France

PEN5 is a sulfated polylactosamine carbohydrate epitope first described in a subpopulation of mature natural killer cells. Here we report that it is also expressed in a developmentally regulated fashion in human and rat central nervous systems and that its protein carrier is P-selectin glycoprotein ligand-1 (PSGL-1), a ligand for selectins. In rat neural primary cultures, PEN5 is transiently and selectively expressed by oligodendrocyte precursor cells and marks the transition from proliferative to postmitotic stages. In concordance, in human central nervous system tumors, PEN5 is observed in a subset of oligodendrogliomas and in all pilocytic astrocytomas, a class of tumor of uncertain histogenesis. These data suggest that PEN5-PSGL-1 plays a role in the differentiation of oligodendrocytes and that pilocytic astrocytomas are likely to result from a dysregulation occurring in oligodendrocyte precursor cells at the crucial stage of exit from the cell cycle.

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