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(American Journal of Pathology. 1999;155:1519-1523.)
© 1999 American Society for Investigative Pathology

Regular Articles

Loss of Retinoic Acid Receptor-ß Expression Is an Early Event during Esophageal Carcinogenesis

Hongming Qiu*, Wei Zhang{dagger}, Adel K. El-Naggar{ddagger}, Scott M. Lippman*, Peizhong Lin{dagger}, Reuben Lotan§ and Xiao-Chun Xu*

From the Departments of Clinical Cancer Prevention,*
Thoracic/Head and Neck Medical Oncology,§
and Pathology,{ddagger}
University of Texas M. D. Anderson Cancer Center, Houston, Texas; and the Center Laboratory for Tumor Biology,{dagger}
Cancer Institute and Hospital, Chinese Academy of Medical Science, Beijing, China

We recently observed that growth inhibition of esophageal cancer cells by retinoic acid (RA) was associated with both constitutive expression and RA-induced up-regulation of RA receptor ß (RAR-ß). Cell lines that did not express RAR-ß were also resistant to RA. To explore the expression of RAR-ß mRNA in vivo, we analyzed esophageal tissue specimens from 16 normal mucosae, 30 dysplastic lesions, and 157 esophageal tumors by in situ hybridization. RAR-ß was detected in 88% (14/16) of normal esophageal tissues and in 96% (96/100) of distant normal esophageal mucosa from cancer specimens. In contrast, RAR-ß was expressed in only 57% (17/30) of dysplastic lesions and in 54% (84/157) of carcinomas. Among esophageal carcinomas RAR-ß mRNA was expressed in 62% (26/42) of well-differentiated, 54% (27/50) of moderately differentiated, and only 29% (4/14) of poorly differentiated SCCs. Our data suggest that the loss of RAR-ß expression is an early event associated with esophageal carcinogenesis and the status of squamous differentiation.




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Copyright © 1999 by the American Society for Investigative Pathology.