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(American Journal of Pathology. 1999;155:2057-2066.)
© 1999 American Society for Investigative Pathology

Regular Articles

Psoriasin (S100A7) Expression and Invasive Breast Cancer

Sahar Al-Haddad*, Zi Zhang*, Etienne Leygue{dagger}, Linda Snell*, Aihua Huang*, Yulian Niu*, Tamara Hiller-Hitchcock*, Kate Hole*, Leigh C. Murphy{dagger} and Peter H. Watson*

Departments of Pathology*
and Biochemistry and Molecular Biology,{dagger}
University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada

Alteration of psoriasin (S100A7) expression has previously been identified in association with the transition from preinvasive to invasive breast cancer. In this study we have examined persistence of psoriasin mRNA and protein expression in relation to prognostic factors in a cohort of 57 invasive breast tumors, comprising 34 invasive ductal carcinomas and 23 other invasive tumor types (lobular, mucinous, medullary, tubular). We first developed an IgY polyclonal chicken antibody and confirmed specificity for psoriasin by Western blot in transfected cells and tumors. The protein was localized by immunohistochemistry predominantly to epithelial cells, with both nuclear and cytoplasmic staining, as well as occasional stromal cells in psoriatic skin and breast tumors; however, in situ hybridization showed that psoriasin mRNA expression was restricted to epithelial cells. In breast tumors, higher levels of psoriasin measured by reverse transcriptase-polymerase chain reaction and Western blot (93% concordance) were significantly associated with estrogen and progesterone receptor-negative status (P < 0.0001, P = 0.0003), and with nodal metastasis in invasive ductal tumors (P = 0.035), but not with tumor type or grade. Psoriasin expression also correlated with inflammatory infiltrates (all tumors excluding medullary, P = 0.0022). These results suggest that psoriasin may be a marker of aggressive behavior in invasive tumors and are consistent with a function as a chemotactic factor.




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