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(American Journal of Pathology. 2000;156:29-35.)
© 2000 American Society for Investigative Pathology

Short Communications

Estrogen Receptor ß Is Coexpressed with ER{alpha} and PR and Associated with Nodal Status, Grade, and Proliferation Rate in Breast Cancer

Tero A. H. Järvinen*, Markku Pelto-Huikko{dagger}, Kaija Holli{ddagger} and Jorma Isola*

From the Laboratory of Cancer Biology,*
Institute of Medical Technology, Tampere University and University Hospital, Tampere; the Medical School,{dagger}
University of Tampere, Tampere; and the Department of Oncology,{ddagger}
Tampere University Hospital, Tampere, Finland

The role of estrogen (ER) and progesterone receptors (PR) in breast cancer is well established. Identification of the second human estrogen receptor, the estrogen receptor ß (ERß), prompted us to evaluate its role in breast cancer. We studied the expression of ERß by immunohistochemistry and mRNA in situ hybridization in 92 primary breast cancers and studied its association with ER{alpha}, PR, and various other clinicopathological factors. Sixty percent of tumors were defined as ERß-positive (nuclear staining in >20% of the cancer cells). Normal ductal epithelium and 5 of 7 intraductal cancers were also found to express ERß. Three-fourths of the ER{alpha}- and PR-positive tumors were positive for ERß, whereas ER{alpha} and PR were positive in 87% and 67% of ERß-positive tumors, respectively. ERß was associated with negative axillary node status (P < 0.0001), low grade (P = 0.0003), low S-phase fraction (P = 0.0003), and premenopausal status (P = 0.04). In conclusion, the coexpression of ERß with ER{alpha} and PR as well as its association with the other indicators of low biological aggressiveness of breast cancer suggest that ERß-positive tumors are likely to respond to hormonal therapy. The independent predictive value of ERß remains to be established.




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