help button home button Am J Pathol ASIP MEMBERSHIP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dombrowski, F.
Right arrow Articles by Bannasch, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dombrowski, F.
Right arrow Articles by Bannasch, P.
(American Journal of Pathology. 2000;156:99-113.)
© 2000 American Society for Investigative Pathology

Regular Articles

Hyperproliferative Hepatocellular Alterations after Intraportal Transplantation of Thyroid Follicles

Frank Dombrowski*, Luisa Klotz*, Hans Jörg Hacker{dagger}, Yanhua Li{dagger}, Dietrich Klingmüller{ddagger}, Klaudia Brix§, Volker Herzog§ and Peter Bannasch{dagger}

From the Pathologisches Institut,*
the Institut für Klinische Biochemie,{ddagger}
and the Institut für Zellbiologie,§
Universität Bonn, Bonn; and the Abteilung für Cytopathologie,{dagger}
Deutsches Krebsforschungszentrum, Heidelberg, Germany

The thyroid hormone 3,5,3'-triiodo-L-thyronine (T3) is a strong direct hepatocyte mitogen in vivo. The effects of T3 resemble those of peroxisome proliferators, which are known to induce hepatocellular tumors in rats. With the aim of studying long-term local effects of thyroid hormones on liver parenchyma, small pieces of thyroid tissue were transplanted via the portal veins into the livers of thyroidectomized male Lewis rats. At 1 week, 3 weeks, 3 months, and 18 months after transplantation, the transplants were found to proliferate, to synthesize thyroglobulin, and to release thyroxine and T3. At 3 and 18 months after transplantation, the hepatocytes of the liver acini downstream of the transplanted follicles showed an increase in cytoplasmic basophilia, a loss of glycogen, an enlargement and hyperchromasia of their nuclei, and a strong increase in cell turnover compared with unaltered liver acini. The altered hepatocytes exhibited an increase in the activities of glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, malic enzyme, mitochondrial glycerol-3-phosphate dehydrogenase, cytochrome-c-oxidase, and acid phosphatase; the activities of glycogen synthase and glycogen phosphorylase were strongly decreased. The hepatocytic alterations downstream of the transplanted follicles could be explained by effects of T3. On the other hand, they resembled alterations characteristic of amphophilic preneoplastic liver foci observed in different models of hepatocarcinogenesis.




This article has been cited by other articles:


Home page
 Toxicol PatholHome page
G. M. Ledda-Columbano, A. Perra, D. Concas, C. Cossu, F. Molotzu, C. Sartori, H. Shinozuka, and A. Columbano
Different Effects of the Liver Mitogens Triiodo-Thyronine and Ciprofibrate on the Development of Rat Hepatocellular Carcinoma
Toxicol Pathol, January 1, 2003; 31(1): 113 - 120.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
R. T. Miller, L. A. Scappino, S. M. Long, and J. C. Corton
Role of Thyroid Hormones in Hepatic Effects of Peroxisome Proliferators
Toxicol Pathol, January 1, 2001; 29(1): 149 - 155.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
L. Klotz, H. J. Hacker, D. Klingmuller, P. Bannasch, U. Pfeifer, and F. Dombrowski
Hepatocellular Alterations after Intraportal Transplantation of Ovarian Tissue in Ovariectomized Rats
Am. J. Pathol., May 1, 2000; 156(5): 1613 - 1626.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Society for Investigative Pathology.