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(American Journal of Pathology. 2000;156:439-443.)
© 2000 American Society for Investigative Pathology

Short Communications

In Vitro Induction of Giant Cell Tumors from Cultured Hamster Islets Treated with N-Nitrosobis(2-Oxopropyl)amine

Hosei Matsuzaki*{dagger}, Bruno M. Schmied*{ddagger}, Alexis Ulrich*§, Surinder K. Batra and Parviz M. Pour*||

From the UNMC Eppley Cancer Center,*
University of Nebraska Medical Center, Omaha, Nebraska; the Department of Surgery II,{dagger}
Kumamoto University School of Medicine, Kumamoto, Japan; the Department of Visceral and Transplantation Surgery,{ddagger}
Insel Hospital, Bern, Switzerland; the Department of Surgery,§
Rheinische Friedrich-Wilhelms-University, Bonn, Germany; and the Departments of Biochemistry and Molecular Biology
and Microbiology,||
University of Nebraska Medical Center, Omaha, Nebraska

Giant cell carcinoma of the pancreas is a rare tumor. Its histogenesis is still controversial. In a Syrian hamster pancreatic cancer model, tumors similar to human giant cell carcinomas have been induced at an extremely low rate of incidence and after the use of high doses of pancreatic carcinogens. Thus far no tumors of giant cell type have been induced by the in vitro treatment of hamster pancreatic ductal cells with the potent pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP). In the present study we report the induction of giant cell carcinoma from hamster islets treated with BOP in vitro. The results suggest that in hamsters some component of islet cells, probably stem cells, are the origin of giant cell carcinoma.






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Copyright © 2000 by the American Society for Investigative Pathology.