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From the Department of Pathology,*
College of Physicians
and Surgeons, Columbia University, New York, New York; the
Department of Pathology,
Lugio
Sacco Hospital, Milan, Italy; the Department of Microbiology, Molecular
Genetics and Immunology,
The University of
Kansas Medical Center, Kansas City, Kansas; the Institute of Infectious
Disease and Tropical Medicine,§
University of
Milan, Luigi Sacco Hospital, Milan, Italy; the Department of
Pathology,¶
IRCCS Ospedale San Matteo, University
of Pavia, Pravia, Italy; and the Division of
Epidemiology,||
Columbia University, New York,
New York
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is linked to KS, primary effusion lymphomas (PEL), and a subset of multicentric Castleman’s disease (MCD). Transcript mapping studies using PEL cell lines have allowed preliminary classification of viral gene expression into constitutive (class I) and inducible (class II/III) categories. To determine whether viral gene expression differs in vivo, we examined tissue sections of KSHV-infected disorders, using specific antibodies against proteins that are representative of the different expression classes of KSHV genes. ORF73/LANA appears to be a surrogate marker for KSHV infection because it is constitutively expressed in vitro and in vivo in all KSHV-infected cells. Expression of vIRF1, vIL6, and PF-8 proteins in the infected B cells of MCD lymph nodes reproduces the expression pattern observed in TPA-stimulated KSHV-infected B-cell lines. In contrast, the protein expression of the inducible viral genes that we tested in KS and PEL biopsies is restricted to PF-8 and vIL6, respectively. The tightly restricted expression of KSHV proteins in vivo differs from the dysregulated expression of inducible KSHV genes in vitro and suggests that viral gene expression in KSHV-infected cell lines does not accurately reflect what occurs in diseased tissues. These differences may be related to either cell-specific or immune restriction of viral replication.
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A. K. Groves, M. A. Cotter, C. Subramanian, and E. S. Robertson The Latency-Associated Nuclear Antigen Encoded by Kaposi's Sarcoma-Associated Herpesvirus Activates Two Major Essential Epstein-Barr Virus Latent Promoters J. Virol., October 1, 2001; 75(19): 9446 - 9457. [Abstract] [Full Text] [PDF]
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E Caussinus, F Meggetto, G Delsol, and P Brousset Simultaneous occurrence of Epstein-Barr virus associated Hodgkin's disease and HHV-8 related multicentric Castleman's disease: a fortuitous event? J. Clin. Pathol., October 1, 2001; 54(10): 790 - 791. [Abstract] [Full Text] [PDF]
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P. Rimessi, A. Bonaccorsi, M. Sturzl, M. Fabris, E. Brocca-Cofano, A. Caputo, G. Melucci-Vigo, M. Falchi, A. Cafaro, E. Cassai, et al. Transcription Pattern of Human Herpesvirus 8 Open Reading Frame K3 in Primary Effusion Lymphoma and Kaposi's Sarcoma J. Virol., August 1, 2001; 75(15): 7161 - 7174. [Abstract] [Full Text]
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T. Seo, J. Park, D. Lee, S. G. Hwang, and J. Choe Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Binds to p53 and Represses p53-Dependent Transcription and Apoptosis J. Virol., July 1, 2001; 75(13): 6193 - 6198. [Abstract] [Full Text] [PDF]
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M. Haque, K. Ueda, K. Nakano, Y. Hirata, C. Parravicini, M. Corbellino, and K. Yamanishi Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 J. Gen. Virol., May 1, 2001; 82(5): 1175 - 1180. [Abstract] [Full Text]
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H. Li, H. Wang, and J. Nicholas Detection of Direct Binding of Human Herpesvirus 8-Encoded Interleukin-6 (vIL-6) to both gp130 and IL-6 Receptor (IL-6R) and Identification of Amino Acid Residues of vIL-6 Important for IL-6R-Dependent and -Independent Signaling J. Virol., April 1, 2001; 75(7): 3325 - 3334. [Abstract] [Full Text]
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M.-Q. Du, H. Liu, T. C. Diss, H. Ye, R. A. Hamoudi, N. Dupin, V. Meignin, E. Oksenhendler, C. Boshoff, and P. G. Isaacson Kaposi sarcoma-associated herpesvirus infects monotypic (IgM{lambda}) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders Blood, April 1, 2001; 97(7): 2130 - 2136. [Abstract] [Full Text] [PDF]
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J. Chen, K. Ueda, S. Sakakibara, T. Okuno, C. Parravicini, M. Corbellino, and K. Yamanishi Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator PNAS, March 27, 2001; 98(7): 4119 - 4124. [Abstract] [Full Text] [PDF]
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C. Rivas, A.-E. Thlick, C. Parravicini, P. S. Moore, and Y. Chang Kaposi's Sarcoma-Associated Herpesvirus LANA2 Is a B-Cell-Specific Latent Viral Protein That Inhibits p53 J. Virol., January 1, 2001; 75(1): 429 - 438. [Abstract] [Full Text]
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A. Krithivas, D. B. Young, G. Liao, D. Greene, and S. D. Hayward Human Herpesvirus 8 LANA Interacts with Proteins of the mSin3 Corepressor Complex and Negatively Regulates Epstein-Barr Virus Gene Expression in Dually Infected PEL Cells J. Virol., October 15, 2000; 74(20): 9637 - 9645. [Abstract] [Full Text]
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 K. Washenik, L. Clark-Loeser, A. Friedman-Kien, T. Simonart, J.-P. V. Vooren, S. Meuris, A. Mazzone, E. Ottini, M. Paulli, K. Antman, et al. Kaposi's Sarcoma N. Engl. J. Med., August 24, 2000; 343(8): 581 - 584. [Full Text]
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