| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Review |
From the Departments of Pathology and Laboratory
Medicine*
and Medical
Physiology,
Texas A&M University Health
Science Center, College Station, Texas
Extracellular matrix (ECM) is known to provide signals controlling cell shape, migration, proliferation, differentiation, morphogenesis, and survival. Recent data shows that some of these signals are derived from biologically active cryptic sites within matrix molecules (matricryptic sites) that are revealed after structural or conformational alteration of these molecules. We propose the name, matricryptins, for enzymatic fragments of ECM containing exposed matricryptic sites. Mechanisms regulating the exposure of matricryptic sites within ECM molecules include the major mechanism of enzymatic breakdown as well as others including ECM protein multimerization, adsorption to other molecules, cell-mediated mechanical forces, and ECM denaturation. Such matrix alterations occur during or as a result of tissue injury, and thus, the appearance of matricryptic sites within an injury site may provide important new signals to regulate the repair process. Here, we review the data supporting this concept and provide insight into why the increased exposure of matricryptic sites may be an important regulatory step in tissue responses to injury.
This article has been cited by other articles:
 |
|
 |
|
  Y. Yang, X. Wu, P. Gui, J. Wu, J.-Z. Sheng, S. Ling, A. P. Braun, G. E. Davis, and M. J. Davis {alpha}5{beta}1 Integrin Engagement Increases Large Conductance, Ca2+-activated K+ Channel Current and Ca2+ Sensitivity through c-src-mediated Channel Phosphorylation J. Biol. Chem., January 1, 2010; 285(1): 131 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tanaka, T. Owaki, S. Kamiya, T. Matsunaga, K. Shimoda, H. Kodama, R. Hayashi, T. Abe, Y. P. Harada, M. Shimonaka, et al. VLA-5-mediated Adhesion to Fibronectin Accelerates Hemin-stimulated Erythroid Differentiation of K562 Cells through Induction of VLA-4 Expression J. Biol. Chem., July 24, 2009; 284(30): 19817 - 19825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Stratman, W. B. Saunders, A. Sacharidou, W. Koh, K. E. Fisher, D. C. Zawieja, M. J. Davis, and G. E. Davis Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices Blood, July 9, 2009; 114(2): 237 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Heilpern, W. Wertheim, J. He, G. Perides, R. T. Bronson, and L. T. Hu Matrix Metalloproteinase 9 Plays a Key Role in Lyme Arthritis but Not in Dissemination of Borrelia burgdorferi Infect. Immun., July 1, 2009; 77(7): 2643 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Chautard, L. Ballut, N. Thierry-Mieg, and S. Ricard-Blum MatrixDB, a database focused on extracellular protein-protein and protein-carbohydrate interactions Bioinformatics, March 1, 2009; 25(5): 690 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Dalmas, M. S. Scicchitano, Y. Chen, J. Kane, R. Mirabile, L. W. Schwartz, H. C. Thomas, and R. W. Boyce Transcriptional Profiling of Laser Capture Microdissected Rat Arterial Elements: Fenoldopam-induced Vascular Toxicity as a Model System Toxicol Pathol, April 1, 2008; 36(3): 496 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wu, Y. Yang, P. Gui, Y. Sohma, G. A. Meininger, G. E. Davis, A. P. Braun, and M. J. Davis Potentiation of large conductance, Ca2+-activated K+ (BK) channels by {alpha}5{beta}1 integrin activation in arteriolar smooth muscle J. Physiol., March 15, 2008; 586(6): 1699 - 1713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Hermann, J. J. Nicol, A. G. M. Bulloch, and W. C. Wildering RGD-dependent mechanisms in the endoneurial phagocyte response and axonal regeneration in the nervous system of the snail Lymnaea stagnalis J. Exp. Biol., February 15, 2008; 211(4): 491 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Hocking, P. A. Titus, R. Sumagin, and I. H. Sarelius Extracellular Matrix Fibronectin Mechanically Couples Skeletal Muscle Contraction With Local Vasodilation Circ. Res., February 15, 2008; 102(3): 372 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Shinde, C. Bystroff, C. Wang, M. G. Vogelezang, P. A. Vincent, R. O. Hynes, and L. Van De Water Identification of the Peptide Sequences within the EIIIA (EDA) Segment of Fibronectin That Mediate Integrin {alpha}9{beta}1-dependent Cellular Activities J. Biol. Chem., February 1, 2008; 283(5): 2858 - 2870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Saito, H. Imazeki, S. Miura, T. Yoshimura, H. Okutsu, Y. Harada, T. Ohwaki, O. Nagao, S. Kamiya, R. Hayashi, et al. A Peptide Derived from Tenascin-C Induces 1 Integrin Activation through Syndecan-4 J. Biol. Chem., November 30, 2007; 282(48): 34929 - 34937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Freitas, V. F. Vilas-Boas, D. C. Pimenta, V. Loureiro, M. A. Juliano, M. R. Carvalho, J. J.V. Pinheiro, A. C.M. Camargo, A. S. Moriscot, M. P. Hoffman, et al. SIKVAV, a Laminin {alpha}1-Derived Peptide, Interacts with Integrins and Increases Protease Activity of a Human Salivary Gland Adenoid Cystic Carcinoma Cell Line through the ERK 1/2 Signaling Pathway Am. J. Pathol., July 1, 2007; 171(1): 124 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Agren and M. Werthen The Extracellular Matrix in Wound Healing: A Closer Look at Therapeutics for Chronic Wounds International Journal of Lower Extremity Wounds, June 1, 2007; 6(2): 82 - 97. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Akalu, J. M. Roth, M. Caunt, D. Policarpio, L. Liebes, and P. C. Brooks Inhibition of Angiogenesis and Tumor Metastasis by Targeting a Matrix Immobilized Cryptic Extracellular Matrix Epitope in Laminin Cancer Res., May 1, 2007; 67(9): 4353 - 4363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ramont, S. Brassart-Pasco, J. Thevenard, A. Deshorgue, L. Venteo, J. Y. Laronze, M. Pluot, J.-C. Monboisse, and F.-X. Maquart The NC1 domain of type XIX collagen inhibits in vivo melanoma growth Mol. Cancer Ther., February 1, 2007; 6(2): 506 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Umesh, M. A. Thompson, E. N. Chini, K.-P. Yip, and J. S. K. Sham Integrin Ligands Mobilize Ca2+ from Ryanodine Receptor-gated Stores and Lysosome-related Acidic Organelles in Pulmonary Arterial Smooth Muscle Cells J. Biol. Chem., November 10, 2006; 281(45): 34312 - 34323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gui, X. Wu, S. Ling, S. C. Stotz, R. J. Winkfein, E. Wilson, G. E. Davis, A. P. Braun, G. W. Zamponi, and M. J. Davis Integrin Receptor Activation Triggers Converging Regulation of Cav1.2 Calcium Channels by c-Src and Protein Kinase A Pathways J. Biol. Chem., May 19, 2006; 281(20): 14015 - 14025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Roth, M. Caunt, A. Cretu, A. Akalu, D. Policarpio, X. Li, P. Gagne, S. Formenti, and P. C. Brooks Inhibition of Experimental Metastasis by Targeting the HUIV26 Cryptic Epitope in Collagen Am. J. Pathol., May 1, 2006; 168(5): 1576 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Leslie Environmental movement. Sci. Aging Knowl. Environ., March 15, 2006; 2006(7): nf9 - nf9. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. M. Sweitzer, S. A. Fann, T. K. Borg, J. W. Baynes, and M. J. Yost What is the future of diabetic wound care? The Diabetes Educator, March 1, 2006; 32(2): 197 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Martinez-Lemus, T. Crow, M. J. Davis, and G. A. Meininger {alpha}v{beta}3- and {alpha}5{beta}1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H322 - H329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sarin, R. D Gaffin, G. A Meininger, and M. Muthuchamy Arginine-glycine-aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via {alpha}5{beta}1 integrin J. Physiol., April 15, 2005; 564(2): 603 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Shanker, K. Yamada, K. G. Green, K. A. Yamada, and J. E. Saffitz Matrix Protein-Specific Regulation of Cx43 Expression in Cardiac Myocytes Subjected to Mechanical Load Circ. Res., March 18, 2005; 96(5): 558 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ling, J.-Z. Sheng, and A. P. Braun The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation Am J Physiol Cell Physiol, September 1, 2004; 287(3): C698 - C706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Rosario, S. W. Waldo, S. A. Becker, and G. W. Schmid-Schonbein Pancreatic Trypsin Increases Matrix Metalloproteinase-9 Accumulation and Activation during Acute Intestinal Ischemia-Reperfusion in the Rat Am. J. Pathol., May 1, 2004; 164(5): 1707 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Margosio, D. Marchetti, V. Vergani, R. Giavazzi, M. Rusnati, M. Presta, and G. Taraboletti Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2 Blood, December 15, 2003; 102(13): 4399 - 4406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Balasubramanian and D. Kuppuswamy RGD-containing Peptides Activate S6K1 through {beta}3 Integrin in Adult Cardiac Muscle Cells J. Biol. Chem., October 24, 2003; 278(43): 42214 - 42224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. M. Verderio, D. Telci, A. Okoye, G. Melino, and M. Griffin A Novel RGD-independent Cell Adhesion Pathway Mediated by Fibronectin-bound Tissue Transglutaminase Rescues Cells from Anoikis J. Biol. Chem., October 24, 2003; 278(43): 42604 - 42614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Moyano, A. Maqueda, B. Casanova, and A. Garcia-Pardo {alpha}4{beta}1 Integrin/Ligand Interaction Inhibits {alpha}5{beta}1-induced Stress Fibers and Focal Adhesions via Down-Regulation of RhoA and Induces Melanoma Cell Migration Mol. Biol. Cell, September 1, 2003; 14(9): 3699 - 3715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Hocking and C. H. Chang Fibronectin matrix polymerization regulates small airway epithelial cell migration Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L169 - L179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lin, A. C. Arai, G. Lynch, and C. M. Gall Integrins Regulate NMDA Receptor-Mediated Synaptic Currents J Neurophysiol, May 1, 2003; 89(5): 2874 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Kramar, J. A. Bernard, C. M. Gall, and G. Lynch Integrins Modulate Fast Excitatory Transmission at Hippocampal Synapses J. Biol. Chem., March 14, 2003; 278(12): 10722 - 10730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shimizu, X. Zhang, J. Zhang, A. Leontovich, K. Fei, L. Yan, and M. P. Sarras Jr. Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases Development, March 5, 2003; 129(6): 1521 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ruehl, R. Somasundaram, I. Schoenfelder, R. W. Farndale, C. G. Knight, M. Schmid, R. Ackermann, E. O. Riecken, M. Zeitz, and D. Schuppan The Epithelial Mitogen Keratinocyte Growth Factor Binds to Collagens via the Consensus Sequence Glycine-Proline-Hydroxyproline J. Biol. Chem., July 19, 2002; 277(30): 26872 - 26878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Hocking and K. Kowalski A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility J. Cell Biol., July 8, 2002; 158(1): 175 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. F. Khan, G. W. Laurie, T. A. McCaffrey, and D. J. Falcone Exposure of Cryptic Domains in the alpha 1-chain of Laminin-1 by Elastase Stimulates Macrophages Urokinase and Matrix Metalloproteinase-9 Expression J. Biol. Chem., April 12, 2002; 277(16): 13778 - 13786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Waitkus-Edwards, L. A. Martinez-Lemus, X. Wu, J. P. Trzeciakowski, M. J. Davis, G. E. Davis, and G. A. Meininger {alpha}4{beta}1 Integrin Activation of L-Type Calcium Channels in Vascular Smooth Muscle Causes Arteriole Vasoconstriction Circ. Res., March 8, 2002; 90(4): 473 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Hein, S. H. Platts, K. R. Waitkus-Edwards, L. Kuo, S. A. Mousa, and G. A. Meininger Integrin-binding peptides containing RGD produce coronary arteriolar dilation via cyclooxygenase activation Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2378 - H2384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Alper, E. S. Bergmann-Leitner, T. A. Bennett, N. F. Hacker, K. Stromberg, and W. G. Stetler-Stevenson Epidermal Growth Factor Receptor Signaling and the Invasive Phenotype of Ovarian Carcinoma Cells J Natl Cancer Inst, September 19, 2001; 93(18): 1375 - 1384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, D. Rodriguez, E. Petitclerc, J. J. Kim, M. Hangai, S. M. Yuen, G. E. Davis, and P. C. Brooks Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo J. Cell Biol., September 3, 2001; 154(5): 1069 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H Wu, E. Ustinova, and H. J Granger Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules J. Physiol., May 1, 2001; 532(3): 785 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Davis, X. Wu, T. R. Nurkiewicz, J. Kawasaki, G. E. Davis, M. A. Hill, and G. A. Meininger Integrins and mechanotransduction of the vascular myogenic response Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1427 - H1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Hoegy, H.-R. Oh, M. L. Corcoran, and W. G. Stetler-Stevenson Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Suppresses TKR-Growth Factor Signaling Independent of Metalloproteinase Inhibition J. Biol. Chem., January 26, 2001; 276(5): 3203 - 3214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Bayless and G. E. Davis Identification of Dual alpha 4beta 1 Integrin Binding Sites within a 38 Amino Acid Domain in the N-terminal Thrombin Fragment of Human Osteopontin J. Biol. Chem., April 13, 2001; 276(16): 13483 - 13489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wu, G. E. Davis, G. A. Meininger, E. Wilson, and M. J. Davis Regulation of the L-type Calcium Channel by alpha 5beta 1 Integrin Requires Signaling between Focal Adhesion Proteins J. Biol. Chem., August 3, 2001; 276(32): 30285 - 30292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Waitkus-Edwards, L. A. Martinez-Lemus, X. Wu, J. P. Trzeciakowski, M. J. Davis, G. E. Davis, and G. A. Meininger {alpha}4{beta}1 Integrin Activation of L-Type Calcium Channels in Vascular Smooth Muscle Causes Arteriole Vasoconstriction Circ. Res., March 8, 2002; 90(4): 473 - 480. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
