help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hashimoto, M.
Right arrow Articles by Sugimura, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hashimoto, M.
Right arrow Articles by Sugimura, H.
(American Journal of Pathology. 2000;157:21-27.)
© 2000 American Society for Investigative Pathology

Short Communications

Isolation and Localization of Type IIb Na/Pi Cotransporter in the Developing Rat Lung

Mitsuyoshi Hashimoto*, Dong-Yu Wang*, Takaharu Kamo*, Yue Zhu*{dagger}, Toshifumi Tsujiuchi{ddagger}, Yoichi Konishi{ddagger}, Masamitsu Tanaka* and Haruhiko Sugimura*

From the First Department of Pathology,*
Hamamatsu University School of Medicine, Hamamatsu, Japan; the Cancer Research Institute,{dagger}
China Medical University, Shenyang, China; and the Department of Oncological Pathology,{ddagger}
Cancer Center, Nara Medical College, Nara, Japan

Differential display analysis of rat lung at different developmental stages identified a fragment, HG80, which appeared on embryonic day 16.5 and thereafter. A full-length cDNA derived from a cDNA library of newborn rat lung probed with HG80 was the rat counterpart of sodium-dependent phosphate transporter type IIb and was designated rNaPi IIb. In situ hybridization showed that rNaPi IIb was expressed in type II alveolar cells, suggesting a role in the synthesis of surfactant in the alveoli. The time-dependent changes in localization of this gene in the developing lung and its possible use as a type II pneumocyte marker are discussed.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. Ikegami, A. Falcone, and J. A. Whitsett
STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury
J Appl Physiol, June 1, 2008; 104(6): 1753 - 1760.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Huqun, S. Izumi, H. Miyazawa, K. Ishii, B. Uchiyama, T. Ishida, S. Tanaka, R. Tazawa, S. Fukuyama, T. Tanaka, et al.
Mutations in the SLC34A2 Gene Are Associated with Pulmonary Alveolar Microlithiasis
Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 263 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
F. Yan, R. Angel, and C. M. Ashwell
Characterization of the Chicken Small Intestine Type IIb Sodium Phosphate Cotransporter
Poult. Sci., January 1, 2007; 86(1): 67 - 76.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Shirasawa, N. Fujiwara, S. Hirabayashi, H. Ohno, J. Iida, K. Makita, and Y. Hata
Receptor for advanced glycation end-products is a marker of type I lung alveolar cells
Genes Cells, February 1, 2004; 9(2): 165 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Xu, J. K. Uno, M. Inouye, L. Xu, J. B. Drees, J. F. Collins, and F. K. Ghishan
Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen
Am J Physiol Gastrointest Liver Physiol, December 1, 2003; 285(6): G1317 - G1324.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Xu, L. Bai, J. F. Collins, and F. K. Ghishan
Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)2 vitamin D3
Am J Physiol Cell Physiol, March 1, 2002; 282(3): C487 - C493.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Society for Investigative Pathology.