| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Department of Dermatology,*
Kanazawa University
School of Medicine, Kanazawa, Ishikawa, Japan; and the Department of
Immunology,
Duke University Medical Center,
Durham, North Carolina
Inflammatory cells play a crucial role in wound healing, but the role of adhesion molecules including L-selectin and intercellular adhesion molecule-1 (ICAM-1) is not known in this process. We examined skin wound repair of excisional wounds in mice lacking L-selectin, ICAM-1, or both. The loss of ICAM-1 inhibited wound healing, keratinocyte migration from the edges of the wound toward the center, and granulation tissue formation. By contrast, L-selectin deficiency alone did not affect any of these parameters. However, the loss of both L-selectin and ICAM-1 resulted in inhibition of keratinocyte migration and granulation tissue formation beyond those caused by loss of ICAM-1 alone. Treatment of platelet-derived growth factor to the wounds normalized delayed wound healing in ICAM-1-/- mice, but not in L-selectin/ICAM-1-/- mice. Therefore, although ICAM-1 contributes to wound repair to a greater extent than L-selectin, a role for L-selectin was revealed in the absence of ICAM-1. The impaired wound repair was associated with reduced infiltration of neutrophils and macrophages in ICAM-1-/- and L-selectin/ICAM-1-/- mice. These results demonstrate a distinct role of ICAM-1 and L-selectin in wound healing and that the delayed wound healing in the absence of these molecules is likely because of decreased leukocyte accumulation into the wound site.
This article has been cited by other articles:
 |
|
 |
|
  R. C. Schugart, A. Friedman, R. Zhao, and C. K. Sen Wound angiogenesis as a function of tissue oxygen tension: A mathematical model PNAS, February 19, 2008; 105(7): 2628 - 2633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. MacKinnon, S. L. Farnworth, P. S. Hodkinson, N. C. Henderson, K. M. Atkinson, H. Leffler, U. J. Nilsson, C. Haslett, S. J. Forbes, and T. Sethi Regulation of Alternative Macrophage Activation by Galectin-3 J. Immunol., February 15, 2008; 180(4): 2650 - 2658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, H. Jiao, T. L. Stewart, M. V. H. Lyons, H. A. Shankowsky, P. G. Scott, and E. E. Tredget Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes J. Leukoc. Biol., December 1, 2007; 82(6): 1554 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yukami, M. Hasegawa, Y. Matsushita, T. Fujita, T. Matsushita, M. Horikawa, K. Komura, K. Yanaba, Y. Hamaguchi, T. Nagaoka, et al. Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1 J. Leukoc. Biol., September 1, 2007; 82(3): 519 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Eming, S. Werner, P. Bugnon, C. Wickenhauser, L. Siewe, O. Utermohlen, J. M. Davidson, T. Krieg, and A. Roers Accelerated Wound Closure in Mice Deficient for Interleukin-10 Am. J. Pathol., January 1, 2007; 170(1): 188 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kawasuji, M. Hasegawa, M. Horikawa, T. Fujita, Y. Matsushita, T. Matsushita, M. Fujimoto, D. A. Steeber, T. F. Tedder, K. Takehara, et al. L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury J. Leukoc. Biol., April 1, 2006; 79(4): 696 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Gorvy, S. E. Herrick, M. Shah, and M. W.J. Ferguson Experimental Manipulation of Transforming Growth Factor-{beta} Isoforms Significantly Affects Adhesion Formation in a Murine Surgical Model Am. J. Pathol., October 1, 2005; 167(4): 1005 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Wilson, S. Chettibi, C. Jobin, D. Walbaum, A. J. Rees, and D. C. Kluth Inhibition of Macrophage Nuclear Factor-{kappa}B Leads to a Dominant Anti-Inflammatory Phenotype that Attenuates Glomerular Inflammation in Vivo Am. J. Pathol., July 1, 2005; 167(1): 27 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Hasegawa, S Sato, T Echigo, Y Hamaguchi, M Yasui, and K Takehara Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis Ann Rheum Dis, January 1, 2005; 64(1): 21 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mori, T. Kondo, T. Nishie, T. Ohshima, and M. Asano Impairment of Skin Wound Healing in {beta}-1,4-Galactosyltransferase-Deficient Mice with Reduced Leukocyte Recruitment Am. J. Pathol., April 1, 2004; 164(4): 1303 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ishida, T. Kondo, T. Takayasu, Y. Iwakura, and N. Mukaida The Essential Involvement of Cross-Talk between IFN-{gamma} and TGF-{beta} in the Skin Wound-Healing Process J. Immunol., February 1, 2004; 172(3): 1848 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Komura, M. Hasegawa, Y. Hamaguchi, E. Saito, Y. Kaburagi, K. Yanaba, S. Kawara, K. Takehara, M. Seki, D. A. Steeber, et al. Ultraviolet Light Exposure Suppresses Contact Hypersensitivity by Abrogating Endothelial Intercellular Adhesion Molecule-1 Up-Regulation at the Elicitation Site J. Immunol., September 15, 2003; 171(6): 2855 - 2862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yanaba, Y. Kaburagi, K. Takehara, D. A. Steeber, T. F. Tedder, and S. Sato Relative Contributions of Selectins and Intercellular Adhesion Molecule-1 to Tissue Injury Induced by Immune Complex Deposition Am. J. Pathol., May 1, 2003; 162(5): 1463 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shimada, M. Hasegawa, Y. Kaburagi, Y. Hamaguchi, K. Komura, E. Saito, K. Takehara, D. A. Steeber, T. F. Tedder, and S. Sato L-Selectin or ICAM-1 Deficiency Reduces an Immediate-Type Hypersensitivity Response by Preventing Mast Cell Recruitment in Repeated Elicitation of Contact Hypersensitivity J. Immunol., April 15, 2003; 170(8): 4325 - 4334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hamaguchi, Y. Nishizawa, M. Yasui, M. Hasegawa, Y. Kaburagi, K. Komura, T. Nagaoka, E. Saito, Y. Shimada, K. Takehara, et al. Intercellular Adhesion Molecule-1 and L-Selectin Regulate Bleomycin-Induced Lung Fibrosis Am. J. Pathol., November 1, 2002; 161(5): 1607 - 1618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. MORI, T. KONDO, T. OHSHIMA, Y. ISHIDA, and N. MUKAIDA Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration FASEB J, July 1, 2002; 16(9): 963 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kaburagi, M. Hasegawa, T. Nagaoka, Y. Shimada, Y. Hamaguchi, K. Komura, E. Saito, K. Yanaba, K. Takehara, T. Kadono, et al. The Cutaneous Reverse Arthus Reaction Requires Intercellular Adhesion Molecule 1 and L-Selectin Expression J. Immunol., March 15, 2002; 168(6): 2970 - 2978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Pierce Inflammation in Nonhealing Diabetic Wounds : The Space-Time Continuum Does Matter Am. J. Pathol., August 1, 2001; 159(2): 399 - 403. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
