| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
and HIF-2 in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
From the Nuffield Department of Clinical Laboratory
Sciences,*
University of Oxford, Oxford; the Wellcome Trust
Centre for Human Genetics,
Headington, Oxford;
and the Imperial Cancer Research Fund Molecular Oncology
Laboratory and Angiogenesis Group,
Institute
of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
The cellular response to hypoxia includes the hypoxia-inducible
factor-1 (HIF-1)-induced transcription of genes involved in diverse
processes such as glycolysis and angiogenesis. Induction of the
HIF-regulated genes, as a consequence of the microenvironment
or genetic changes, is known to have an important role in the
growth of experimental tumors. Hypoxia-inducible factors 1
and 2
(HIF-1 and HIF-2) are known to dimerize with the aryl hydrocarbon
receptor nuclear translocator in mediating this response. Because
regulation of the chain protein level is a primary determinant of
HIF activity, our aim was to investigate the distribution of
HIF-1 and HIF-2 by immunohistochemistry in normal and
pathological tissues using monoclonal antibodies (mAb). We raised a new
mAb to detect HIF-1, designated 122, and used our
previously validated mAb 190b to HIF-2. In the majority of solid
tumors examined, including bladder, brain,
breast, colon, ovarian, pancreatic,
prostate, and renal carcinomas, nuclear expression of
HIF-1 and -2 was observed in varying subsets of the tumor cells.
HIF-2 was also strongly expressed by subsets of tumor-associated
macrophages, sometimes in the absence of any tumor cell
expression. Less frequently staining was observed in other stromal
cells within the tumors and in normal tissue adjacent to tumor margins.
In contrast, in normal tissue neither molecule was detectable
except within subsets of bone marrow macrophages, where
HIF-2 was strongly expressed.
This article has been cited by other articles:
 |
|
 |
|
  J. R. Sierra, S. Corso, L. Caione, V. Cepero, P. Conrotto, A. Cignetti, W. Piacibello, A. Kumanogoh, H. Kikutani, P. M. Comoglio, et al. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages J. Exp. Med., July 7, 2008; 205(7): 1673 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamashita, K. Ohneda, M. Nagano, C. Miyoshi, N. Kaneko, Y. Miwa, M. Yamamoto, O. Ohneda, and Y. Fujii-Kuriyama Hypoxia-inducible Transcription Factor-2{alpha} in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1 J. Biol. Chem., July 4, 2008; 283(27): 18926 - 18936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Berchner-Pfannschmidt, S. Frede, C. Wotzlaw, and J. Fandrey Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing Eur. Respir. J., July 1, 2008; 32(1): 210 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Guruvayoorappan Tumor Versus Tumor-Associated Macrophages: How Hot is the Link? Integr Cancer Ther, June 1, 2008; 7(2): 90 - 95. [Abstract] [PDF]
|
|
|
|
 |
|
 R. J. Gillies, I. Robey, and R. A. Gatenby Causes and Consequences of Increased Glucose Metabolism of Cancers J. Nucl. Med., June 1, 2008; 49(Suppl_2): 24S - 42S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Ahn, E.-M. Koh, H.-S. Cha, Y. S. Lee, J. Kim, E.-K. Bae, and K.-S. Ahn Role of hypoxia-inducible factor-1{alpha} in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes Rheumatology, June 1, 2008; 47(6): 834 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C-Y Chai, W-T Chen, W-C Hung, W-Y Kang, Y-C Huang, Y-C Su, and C-H Yang Hypoxia-inducible factor-1{alpha} expression correlates with focal macrophage infiltration, angiogenesis and unfavourable prognosis in urothelial carcinoma J. Clin. Pathol., May 1, 2008; 61(5): 658 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Sluimer, J.-M. Gasc, J. L. van Wanroij, N. Kisters, M. Groeneweg, M. D. Sollewijn Gelpke, J. P. Cleutjens, L. H. van den Akker, P. Corvol, B. G. Wouters, et al. Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis J. Am. Coll. Cardiol., April 1, 2008; 51(13): 1258 - 1265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Battaglia, S. Delfino, E. Merello, M. Puppo, R. Piva, L. Varesio, and M. C. Bosco Hypoxia transcriptionally induces macrophage-inflammatory protein-3{alpha}/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-{kappa}B J. Leukoc. Biol., March 1, 2008; 83(3): 648 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yang, Y. Jiang, S.F. Wu, M.Y. Zhou, Y.L. Wu, and G.Q. Chen CCAAT/enhancer-binding protein {alpha} antagonizes transcriptional activity of hypoxia-inducible factor 1 {alpha} with direct protein-protein interaction Carcinogenesis, February 1, 2008; 29(2): 291 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Lee, W. H. Kim, J. Jung, S. J. Cho, J.-W. Park, J. Kim, H.-Y. Chung, M. S. Chang, and S. Y. Nam A hypoxia-independent up-regulation of hypoxia-inducible factor-1 by AKT contributes to angiogenesis in human gastric cancer Carcinogenesis, January 1, 2008; 29(1): 44 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rapisarda and G. Melillo HIF-1 Inhibitors: Novel Opportunities for Cancer Therapy ASCO Educational Book, January 1, 2008; 2008(1): 543 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Cai, M. Murakami, H. Si, and E. S. Robertson A Potential {alpha}-Helix Motif in the Amino Terminus of LANA Encoded by Kaposi's Sarcoma-Associated Herpesvirus Is Critical for Nuclear Accumulation of HIF-1{alpha} in Normoxia J. Virol., October 1, 2007; 81(19): 10413 - 10423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Post, E. M. Sandberg, M. M. Kyle, N. S. Devi, D. J. Brat, Z. Xu, M. Tighiouart, and E. G. Van Meir Targeted Cancer Gene Therapy Using a Hypoxia Inducible Factor Dependent Oncolytic Adenovirus Armed with Interleukin-4 Cancer Res., July 15, 2007; 67(14): 6872 - 6881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Tang, Q. Zhang, J. Nishitani, J. Brown, S. Shi, and A. D. Le Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Hypoxia-Inducible Factor 1{alpha} Protein Accumulation and Vascular Endothelial Growth Factor Expression in Human Cervical Carcinoma Cells Clin. Cancer Res., May 1, 2007; 13(9): 2568 - 2576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fischer, P. Hoffmann, S. Voelkl, N. Meidenbauer, J. Ammer, M. Edinger, E. Gottfried, S. Schwarz, G. Rothe, S. Hoves, et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells Blood, May 1, 2007; 109(9): 3812 - 3819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Gillespie, K. Whang, B. T. Ragel, J. R. Flynn, D. A. Kelly, and R. L. Jensen Silencing of Hypoxia Inducible Factor-1{alpha} by RNA Interference Attenuates Human Glioma Cell Growth In vivo Clin. Cancer Res., April 15, 2007; 13(8): 2441 - 2448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Horii, Y. Suzuki, Y. Kondo, M. Akimoto, T. Nishimura, Y. Yamabe, M. Sakaue, T. Sano, T. Kitagawa, S. Himeno, et al. Androgen-Dependent Gene Expression of Prostate-Specific Antigen Is Enhanced Synergistically by Hypoxia in Human Prostate Cancer Cells Mol. Cancer Res., April 1, 2007; 5(4): 383 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D.W. van der Bilt, M. E. Soeters, A. M.M.J. Duyverman, M. W. Nijkamp, P. O. Witteveen, P. J. van Diest, O. Kranenburg, and I. H.M. Borel Rinkes Perinecrotic Hypoxia Contributes to Ischemia/Reperfusion-Accelerated Outgrowth of Colorectal Micrometastases Am. J. Pathol., April 1, 2007; 170(4): 1379 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Martin-Rendon, S. J.M. Hale, D. Ryan, D. Baban, S. P. Forde, M. Roubelakis, D. Sweeney, M. Moukayed, A. L. Harris, K. Davies, et al. Transcriptional Profiling of Human Cord Blood CD133+ and Cultured Bone Marrow Mesenchymal Stem Cells in Response to Hypoxia Stem Cells, April 1, 2007; 25(4): 1003 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shinojima, M. Oya, A. Takayanagi, R. Mizuno, N. Shimizu, and M. Murai Renal cancer cells lacking hypoxia inducible factor (HIF)-1{alpha} expression maintain vascular endothelial growth factor expression through HIF-2{alpha} Carcinogenesis, March 1, 2007; 28(3): 529 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Puppo, M. C. Bosco, M. Federico, S. Pastorino, and L. Varesio Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages J. Leukoc. Biol., February 1, 2007; 81(2): 528 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Y. Tan, L. Campo, C. Han, H. Turley, F. Pezzella, K. C. Gatter, A. L. Harris, and S. B. Fox BNIP3 as a Progression Marker in Primary Human Breast Cancer; Opposing Functions in In situ Versus Invasive Cancer Clin. Cancer Res., January 15, 2007; 13(2): 467 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tanaka, M. Yamamoto, N. Hashimoto, M. Miyakoshi, S. Tamakawa, M. Yoshie, Y. Tokusashi, K. Yokoyama, Y. Yaginuma, and K. Ogawa Hypoxia-Independent Overexpression of Hypoxia-Inducible Factor 1{alpha} as an Early Change in Mouse Hepatocarcinogenesis Cancer Res., December 1, 2006; 66(23): 11263 - 11270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Patiar and A. L Harris Role of hypoxia-inducible factor-1{alpha} as a cancer therapy target Endocr. Relat. Cancer, December 1, 2006; 13(Supplement_1): S61 - S75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Ke and M. Costa Hypoxia-Inducible Factor-1 (HIF-1) Mol. Pharmacol., November 1, 2006; 70(5): 1469 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lamagna, M. Aurrand-Lions, and B. A. Imhof Dual role of macrophages in tumor growth and angiogenesis J. Leukoc. Biol., October 1, 2006; 80(4): 705 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Koukourakis, A. Giatromanolaki, E. Sivridis, K. C. Gatter, and A. L. Harris Lactate Dehydrogenase 5 Expression in Operable Colorectal Cancer: Strong Association With Survival and Activated Vascular Endothelial Growth Factor Pathway--A Report of the Tumour Angiogenesis Research Group J. Clin. Oncol., September 10, 2006; 24(26): 4301 - 4308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Woldemichael, J. R. Vasselli, R. S. Gardella, T. C. Mckee, W. M. Linehan, and J. B. McMahon Development of a Cell-Based Reporter Assay for Screening of Inhibitors of Hypoxia-Inducible Factor 2-Induced Gene Expression J Biomol Screen, September 1, 2006; 11(6): 678 - 687. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Herrmann, L. O. Lerman, D. Mukhopadhyay, C. Napoli, and A. Lerman Angiogenesis in Atherogenesis Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1948 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Melillo Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy Mol. Cancer Res., September 1, 2006; 4(9): 601 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Semenza Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1 Exp Physiol, September 1, 2006; 91(5): 803 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Guzy and P. T. Schumacker Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia Exp Physiol, September 1, 2006; 91(5): 807 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Cai, K. Lan, S. C. Verma, H. Si, D. Lin, and E. S. Robertson Kaposi's Sarcoma-Associated Herpesvirus Latent Protein LANA Interacts with HIF-1{alpha} To Upregulate RTA Expression during Hypoxia: Latency Control under Low Oxygen Conditions. J. Virol., August 1, 2006; 80(16): 7965 - 7975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-B. Catrina, I. R. Botusan, A. Rantanen, A. I. Catrina, P. Pyakurel, O. Savu, M. Axelson, P. Biberfeld, L. Poellinger, and K. Brismar Hypoxia-Inducible Factor-1{alpha} and Hypoxia-Inducible Factor-2{alpha} Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-I Clin. Cancer Res., August 1, 2006; 12(15): 4506 - 4514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Generali, A. Berruti, M. P. Brizzi, L. Campo, S. Bonardi, S. Wigfield, A. Bersiga, G. Allevi, M. Milani, S. Aguggini, et al. Hypoxia-Inducible Factor-1{alpha} Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer Clin. Cancer Res., August 1, 2006; 12(15): 4562 - 4568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zheng, J. L. Ruas, R. Cao, F. A. Salomons, Y. Cao, L. Poellinger, and T. Pereira Cell-Type-Specific Regulation of Degradation of Hypoxia-Inducible Factor 1{alpha}: Role of Subcellular Compartmentalization Mol. Cell. Biol., June 15, 2006; 26(12): 4628 - 4641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Aprelikova, M. Wood, S. Tackett, G. V.R. Chandramouli, and J. C. Barrett Role of ETS Transcription Factors in the Hypoxia-Inducible Factor-2 Target Gene Selection Cancer Res., June 1, 2006; 66(11): 5641 - 5647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Fernando, J. E. Simpson, F. Matthews, C. Brayne, C. E. Lewis, R. Barber, R. N. Kalaria, G. Forster, F. Esteves, S. B. Wharton, et al. White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury * Annex - Supplemental Online-Only Content Stroke, June 1, 2006; 37(6): 1391 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-T. Zhou, Y. Yang, and J.-P. Ge The preventive effect of salvianolic acid B on malignant transformation of DMBA-induced oral premalignant lesion in hamsters Carcinogenesis, April 1, 2006; 27(4): 826 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Knowles, D. R. Mole, P. J. Ratcliffe, and A. L. Harris Normoxic Stabilization of Hypoxia-Inducible Factor-1{alpha} by Modulation of the Labile Iron Pool in Differentiating U937 Macrophages: Effect of Natural Resistance-Associated Macrophage Protein 1. Cancer Res., March 1, 2006; 66(5): 2600 - 2607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gottfried, L. A. Kunz-Schughart, S. Ebner, W. Mueller-Klieser, S. Hoves, R. Andreesen, A. Mackensen, and M. Kreutz Tumor-derived lactic acid modulates dendritic cell activation and antigen expression Blood, March 1, 2006; 107(5): 2013 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Koukourakis, S. M. Bentzen, A. Giatromanolaki, G. D. Wilson, F. M. Daley, M. I. Saunders, S. Dische, E. Sivridis, and A. L. Harris Endogenous Markers of Two Separate Hypoxia Response Pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) Are Associated With Radiotherapy Failure in Head and Neck Cancer Patients Recruited in the CHART Randomized Trial J. Clin. Oncol., February 10, 2006; 24(5): 727 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Dang, F. Chen, L. B. Gardner, J. M. Cummins, C. Rago, F. Bunz, S. V. Kantsevoy, and L. H. Dang Hypoxia-Inducible Factor-1{alpha} Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts Cancer Res., February 1, 2006; 66(3): 1684 - 1693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Glasker, R. R. Lonser, M. G.B. Tran, B. Ikejiri, J. A. Butman, W. Zeng, P. H. Maxwell, Z. Zhuang, E. H. Oldfield, and A. O. Vortmeyer Effects of VHL Deficiency on Endolymphatic Duct and Sac Cancer Res., December 1, 2005; 65(23): 10847 - 10853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Murdoch, M. Muthana, and C. E. Lewis Hypoxia Regulates Macrophage Functions in Inflammation J. Immunol., November 15, 2005; 175(10): 6257 - 6263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Boddy, S. B. Fox, C. Han, L. Campo, H. Turley, S. Kanga, P. R. Malone, and A. L. Harris The Androgen Receptor Is Significantly Associated with Vascular Endothelial Growth Factor and Hypoxia Sensing via Hypoxia-Inducible Factors HIF-1a, HIF-2a, and the Prolyl Hydroxylases in Human Prostate Cancer Clin. Cancer Res., November 1, 2005; 11(21): 7658 - 7663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H Maxwell Hypoxia-inducible factor as a physiological regulator Exp Physiol, November 1, 2005; 90(6): 791 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Sivridis, A Giatromanolaki, and M I Koukourakis Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress J. Clin. Pathol., October 1, 2005; 58(10): 1033 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Zhang, X. Tang, Q. Y. Lu, Z. F. Zhang, J. Brown, and A. D. Le Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1{alpha} and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells Mol. Cancer Ther., October 1, 2005; 4(10): 1465 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. An and M. B. Rettig Mechanism of von Hippel-Lindau Protein-Mediated Suppression of Nuclear Factor kappa B Activity Mol. Cell. Biol., September 1, 2005; 25(17): 7546 - 7556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lewis and C. Murdoch Macrophage Responses to Hypoxia: Implications for Tumor Progression and Anti-Cancer Therapies Am. J. Pathol., September 1, 2005; 167(3): 627 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Trisciuoglio, A. Iervolino, G. Zupi, and D. Del Bufalo Involvement of PI3K and MAPK Signaling in bcl-2-induced Vascular Endothelial Growth Factor Expression in Melanoma Cells Mol. Biol. Cell, September 1, 2005; 16(9): 4153 - 4162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Smith, L. Gunaratnam, M. Morley, A. Franovic, K. Mekhail, and S. Lee Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2-Driven VHL-/- Renal Cancer Cancer Res., June 15, 2005; 65(12): 5221 - 5230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Bracken, M. L. Whitelaw, and D. J. Peet Activity of Hypoxia-inducible Factor 2{alpha} Is Regulated by Association with the NF-{kappa}B Essential Modulator J. Biol. Chem., April 8, 2005; 280(14): 14240 - 14251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakanishi, S. Hiroi, S. Tominaga, S. Aida, H. Kasamatsu, S. Matsuyama, T. Matsuyama, and T. Kawai Expression of Hypoxia-Inducible Factor-1{alpha} Protein Predicts Survival in Patients with Transitional Cell Carcinoma of the Upper Urinary Tract Clin. Cancer Res., April 1, 2005; 11(7): 2583 - 2590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Covello, M. C. Simon, and B. Keith Targeted Replacement of Hypoxia-Inducible Factor-1{alpha} by a Hypoxia-Inducible Factor-2{alpha} Knock-in Allele Promotes Tumor Growth Cancer Res., March 15, 2005; 65(6): 2277 - 2286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P J van Diest, M M Vleugel, E van der Wall, M J Currie, V Hanrahan, S P Gunningham, H R Morrin, C Frampton, C Han, B A Robinson, et al. Expression of HIF-1{alpha} in human tumours J. Clin. Pathol., March 1, 2005; 58(3): 335 - 336. [Full Text] [PDF]
|
|
|
|
|
|
S. McMahon, F. Grondin, P. P. McDonald, D. E. Richard, and C. M. Dubois Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1: IMPACT ON THE BIOACTIVATION OF PROPROTEINS J. Biol. Chem., February 25, 2005; 280(8): 6561 - 6569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Walmsley, C. Print, N. Farahi, C. Peyssonnaux, R. S. Johnson, T. Cramer, A. Sobolewski, A. M. Condliffe, A. S. Cowburn, N. Johnson, et al. Hypoxia-induced neutrophil survival is mediated by HIF-1{alpha}-dependent NF-{kappa}B activity J. Exp. Med., January 3, 2005; 201(1): 105 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
