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From the W. M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana
In addition to their well-known roles in hemostasis,
fibrinogen (Fg) and fibrin (Fn) have been implicated in a number of
other physiological and pathophysiological events. One of these
involves the fibroproliferative response after acute lung
injury, which is the focus of the current study. Mice with a
total Fg deficiency (FG-/-) were generated
by breeding heterozygous (FG+/-)
pairs, each of which contained an allele with a targeted
deletion of its Fg-
-chain gene. The resulting
FG-/- animals did not possess detectable
plasma Fg. FG-/- mice were then used to
assess the roles of Fg and Fn in a bleomycin-induced acute lung injury
model. Intratracheal administration of bleomycin in wild-type and
FG-/- mice resulted in equivalent
deposition of interstitial collagen and fibrotic lesions at days 7 and
14 after administration. This indicates that Fg and/or Fn are not
essential for the development of bleomycin-induced pulmonary
fibrosis.
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