| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Departments of Medicine and Therapeutics,*
Anatomical and Cellular Pathology,
and
Surgery,
The Chinese University of Hong Kong,
Prince of Wales Hospital, Shatin, Hong Kong
Expression of cyclooxygenase-2 (COX-2) in various stages of the Helicobacter pylori-associated gastric carcinogenesis pathway has not been elucidated. We investigated the distribution and intensity of COX-2 expression in premalignant and malignant gastric lesions, and monitored the changes after H. pylori eradication. Gastric biopsies from H. pylori-infected patients with chronic active gastritis, gastric atrophy, intestinal metaplasia (IM), gastric adenocarcinoma, and noninfected controls were studied. Expression of COX-2 was evaluated by immunohistochemistry and in situ hybridization. Endoscopic biopsies were repeated 1 year after successful eradication of H. pylori in a group of IM patients for comparing COX-2 expression and progression of IM. In all H. pylori-infected patients, COX-2 expression was predominantly found in the foveolar and glandular epithelium and, to a lesser extent, in the lamina propria. In the noninfected group, only 35% of cases demonstrated weak COX-2 expression. Intensity of COX-2 was not significantly different between the chronic active gastritis, gastric atrophy, IM, and gastric adenocarcinoma groups. In 17 patients with IM, COX-2 expressions in the epithelial cells and stromal cells were reduced 1 year after H. pylori eradication. However, the changes in COX-2 expression did not correlate with progression/regression of IM. Both premalignant and malignant gastric lesions demonstrate strong COX-2 expression. Successful eradication of H. pylori leads to down-regulation of COX-2 expression but failed to reverse IM at 1 year.
This article has been cited by other articles:
 |
|
 |
|
  N. F. Saba, M. Choi, S. Muller, H. J. C. Shin, M. Tighiouart, V. A. Papadimitrakopoulou, A. K. El-Naggar, F. R. Khuri, Z. G. Chen, and D. M. Shin Role of Cyclooxygenase-2 in Tumor Progression and Survival of Head and Neck Squamous Cell Carcinoma Cancer Prevention Research, September 1, 2009; 2(9): 823 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-H. Hung, J.-J. Wu, H.-B. Yang, L.-J. Su, and B.-S. Sheu Host Wnt/{beta}-catenin pathway triggered by Helicobacter pylori correlates with regression of gastric intestinal metaplasia after H. pylori eradication J. Med. Microbiol., May 1, 2009; 58(5): 567 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Oshima, H. Itadani, H. Kotani, M. M. Taketo, and M. Oshima Induction of Prostaglandin E2 Pathway Promotes Gastric Hamartoma Development with Suppression of Bone Morphogenetic Protein Signaling Cancer Res., April 1, 2009; 69(7): 2729 - 2733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. K. Leung, K.-c. Wu, C. Y. P. Wong, A. S. L. Cheng, A. K. K. Ching, A. W. H. Chan, W. W. S. Chong, M. Y. Y. Go, J. Yu, K.-F. To, et al. Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice Carcinogenesis, August 1, 2008; 29(8): 1648 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Liu, X. Wang, Y. Lu, S. Han, F. Zhang, H. Zhai, T. Lei, J. Liang, J. Wang, K. Wu, et al. Expression of 15-PGDH is downregulated by COX-2 in gastric cancer Carcinogenesis, June 1, 2008; 29(6): 1219 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hisatsune, E. Yamasaki, M. Nakayama, D. Shirasaka, H. Kurazono, Y. Katagata, H. Inoue, J. Han, J. Sap, K. Yahiro, et al. Helicobacter pylori VacA Enhances Prostaglandin E2 Production through Induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells Infect. Immun., September 1, 2007; 75(9): 4472 - 4481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gruno, N. Peet, E. Seppet, L. Kadaja, K. Paju, M. Eimre, E. Orlova, M. Peetsalu, A. Tein, J. Soplepmann, et al. Oxidative phosphorylation and its coupling to mitochondrial creatine and adenylate kinases in human gastric mucosa Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R936 - R946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. K. Leung, E. K.W. Ng, F. K.L. Chan, W. Y. Chan, K.-f. Chan, A. C.M. Auyeung, C. C.H. Lam, J. Y.W. Lau, and J. J.Y. Sung Effects of Long-term Rofecoxib on Gastric Intestinal Metaplasia: Results of a Randomized Controlled Trial Clin. Cancer Res., August 1, 2006; 12(15): 4766 - 4772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kanda, H. Seno, M. Kawada, T. Sawabu, Y. Uenoyoma, T. Nakajima, Y. Konda, H. Fukui, T. Takeuchi, and T. Chiba Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice Am J Physiol Gastrointest Liver Physiol, March 1, 2006; 290(3): G519 - G527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oshima, H. Oshima, A. Matsunaga, and M. M. Taketo Hyperplastic Gastric Tumors with Spasmolytic Polypeptide-Expressing Metaplasia Caused by Tumor Necrosis Factor-{alpha}-Dependent Inflammation in Cyclooxygenase-2/Microsomal Prostaglandin E Synthase-1 Transgenic Mice Cancer Res., October 15, 2005; 65(20): 9147 - 9151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mrena, J.-P. Wiksten, A. Thiel, A. Kokkola, L. Pohjola, J. Lundin, S. Nordling, A. Ristimaki, and C. Haglund Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR Clin. Cancer Res., October 15, 2005; 11(20): 7362 - 7368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Copie-Bergman, C. Locher, M. Levy, M. T. Chaumette, C. Haioun, M. H. Delfau-Larue, K. Leroy, P. Gaulard, and J. C. Delchier Metachronous gastric MALT lymphoma and early gastric cancer: is residual lymphoma a risk factor for the development of gastric carcinoma? Ann. Onc., August 1, 2005; 16(8): 1232 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention J. Clin. Oncol., January 10, 2005; 23(2): 254 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Nam, K.-B. Hahm, S.-Y. Oh, M. Yeo, S.-U. Han, B. Ahn, Y.-B. Kim, J. S. Kang, D. D. Jang, K.-H. Yang, et al. The Selective Cyclooxygenase-2 Inhibitor Nimesulide Prevents Helicobacter pylori-Associated Gastric Cancer Development in a Mouse Model Clin. Cancer Res., December 1, 2004; 10(23): 8105 - 8113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Chang, M. S. Wu, J. T. Lin, B. S. Sheu, T. Muta, H. Inoue, and C.-C. Chen Induction of Cyclooxygenase-2 Overexpression in Human Gastric Epithelial Cells by Helicobacter pylori Involves TLR2/TLR9 and c-Src-Dependent Nuclear Factor-{kappa}B Activation Mol. Pharmacol., December 1, 2004; 66(6): 1465 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Borisenko, I. Martin, Q. Zhao, A. A. Amoscato, Y. Y. Tyurina, and V. E. Kagan Glutathione Propagates Oxidative Stress Triggered by Myeloperoxidase in HL-60 Cells: EVIDENCE FOR GLUTATHIONYL RADICAL-INDUCED PEROXIDATION OF PHOSPHOLIPIDS AND CYTOTOXICITY J. Biol. Chem., May 28, 2004; 279(22): 23453 - 23462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. I. Meireles, E. B. Cristo, A. F. Carvalho, R. Hirata Jr., A. Pelosof, L. I. Gomes, W. K. Martins, M. D. Begnami, C. Zitron, A. L. Montagnini, et al. Molecular Classifiers for Gastric Cancer and Nonmalignant Diseases of the Gastric Mucosa Cancer Res., February 15, 2004; 64(4): 1255 - 1265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P J Hu, J Yu, Z R Zeng, W K Leung, H L Lin, B D Tang, A H C Bai, and J J Y Sung Chemoprevention of gastric cancer by celecoxib in rats Gut, February 1, 2004; 53(2): 195 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Akiyama, C. Maesawa, S. Ogasawara, M. Terashima, and T. Masuda Cell-Type-Specific Repression of the Maspin Gene Is Disrupted Frequently by Demethylation at the Promoter Region in Gastric Intestinal Metaplasia and Cancer Cells Am. J. Pathol., November 1, 2003; 163(5): 1911 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-S. Sheu, H.-B. Yang, S.-M. Sheu, A.-H. Huang, and J.-J. Wu Higher Gastric Cycloxygenase-2 Expression and Precancerous Change in Helicobacter pylori-Infected Relatives of Gastric Cancer Patients Clin. Cancer Res., November 1, 2003; 9(14): 5245 - 5251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Choy and L. Milas Enhancing Radiotherapy With Cyclooxygenase-2 Enzyme Inhibitors: A Rational Advance? J Natl Cancer Inst, October 1, 2003; 95(19): 1440 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Futagami, T Hiratsuka, A Tatsuguchi, K Suzuki, M Kusunoki, Y Shinji, K Shinoki, T Iizumi, T Akamatsu, H Nishigaki, et al. Monocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells Gut, September 1, 2003; 52(9): 1257 - 1264. [Abstract] [Full Text]
|
|
|
|
|
|
M M Walker Is intestinal metaplasia of the stomach reversible? Gut, January 1, 2003; 52(1): 1 - 4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Lim, H. Kim, and K. H. Kim Expression of Ku70 and Ku80 Mediated by NF-kappa B and Cyclooxygenase-2 Is Related to Proliferation of Human Gastric Cancer Cells J. Biol. Chem., November 22, 2002; 277(48): 46093 - 46100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lajoie, J. Sirois, and M. Dore Induction of Cyclo-oxygenase-2 Expression in Naturally Occurring Gastric Ulcers J. Histochem. Cytochem., July 1, 2002; 50(7): 923 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saukkonen, O. Nieminen, B. van Rees, S. Vilkki, M. Harkonen, M. Juhola, J.-P. Mecklin, P. Sipponen, and A. Ristimaki Expression of Cyclooxygenase-2 in Dysplasia of the Stomach and in Intestinal-type Gastric Adenocarcinoma Clin. Cancer Res., July 1, 2001; 7(7): 1923 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shono, P. J. Tofilon, J. M. Bruner, O. Owolabi, and F. F. Lang Cyclooxygenase-2 Expression in Human Gliomas: Prognostic Significance and Molecular Correlations Cancer Res., June 1, 2001; 61(11): 4375 - 4381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Akhtar, Y. Cheng, R. M. Magno, H. Ashktorab, D. T. Smoot, S. J. Meltzer, and K. T. Wilson Promoter Methylation Regulates Helicobacter pylori-stimulated Cyclooxygenase-2 Expression in Gastric Epithelial Cells Cancer Res., March 1, 2001; 61(6): 2399 - 2403. [Abstract] [Full Text]
|
|
|
|
|
|
R. A. Gupta, D. B. Polk, U. Krishna, D. A. Israel, F. Yan, R. N. DuBois, and R. M. Peek Jr. Activation of Peroxisome Proliferator-activated Receptor gamma Suppresses Nuclear Factor kappa B-mediated Apoptosis Induced by Helicobacter pylori in Gastric Epithelial Cells J. Biol. Chem., August 10, 2001; 276(33): 31059 - 31066. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
