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(American Journal of Pathology. 2000;157:1055-1062.)
© 2000 American Society for Investigative Pathology

Short Communications

Prevalence of Human Papillomavirus DNA in Different Histological Subtypes of Cervical Adenocarcinoma

Edyta C. Pirog^*, Bernhard Kleter, Semra Olgac, Piotr Bobkiewicz^§, Jan Lindeman^¶, Wim G. V. Quint, Ralph M. Richart^|| and Christina Isacson^*

From the Department of Pathology,^*
Weill Medical College of Cornell University, New York, New York; the Department of Pathology,
Lenox Hill Hospital, New York, New York; the Department of Pathology,^||
College of Physicians and Surgeons of Columbia University, New York, New York; the Delft Diagnostic Laboratory,
Delft, the Netherlands; the Department of Pathology,^¶
Slotervaartziekenhuis, Amsterdam, The Netherlands; and the Laboratory of Reproductive Pathomorphology,^§
Warsaw Medical School, Warsaw, Poland

The prevalence of human papilloma virus (HPV) DNA in different histological subtypes of cervical adenocarcinoma and related tumors was examined using formalin-fixed, paraffin-embedded tissue samples from 105 primary cervical adenocarcinomas and adenosquamous carcinomas. Broad-spectrum HPV DNA amplification and genotyping was performed with the SPF10 primer set and line probe assay (LiPA), respectively. HPV DNA was detected in 82 of 90 (91%) mucinous adenocarcinomas, encompassing endocervical, intestinal, and endometrioid histological subtypes, and in nine of nine adenosquamous tumors (100%). HPV DNA was not detected in any nonmucinous adenocarcinomas including clear cell, serous, and mesonephric carcinomas (0/6). The most common viral types detected in adenocarcinoma were HPV 16 (50%) and HPV 18 (40%), followed by HPV 45 (10%), HPV52 (2%), and HPV 35 (1%). Multiple HPV types were detected in 9.7% of the cases. In conclusion, mucinous adenocarcinomas and adenosquamous carcinomas of the cervix demonstrate a very high prevalence of HPV DNA, similar to that reported for cervical squamous cell carcinoma. Only rare histological variants of cervical adenocarcinoma seem unrelated to HPV infection.

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