| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Department of Histopathology,*
Royal Free and
University College Medical School, London, United Kingdom; the Academic
Department of Haematology and Cytogenetics,
Institute of Cancer Research, Sutton, Surrey, United Kingdom; and The
Center for Human Genetics and Flanders Institute of
Biotechnology,
University of Leuven, Leuven,
Belgium
BCL10 is an apoptotic regulatory molecule identified through its direct involvement in t(1;14)(p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. We examined BCL10 protein expression in various normal tissues and B-cell lymphomas by immunohistochemistry of formalin-fixed and paraffin-embedded tissues using mouse BCL10 monoclonal antibodies. BCL10 protein was expressed in lymphoid tissue but not in 21 various other tissues with the exception of breast. In normal B-cell follicles, the protein was expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in the mantle zone B cells. Irrespective of their stage of B-cell maturation, BCL10 was predominantly expressed in the cytoplasm. In contrast, each of the four MALT lymphomas with t(1;14)(p22;q32) showed strong BCL10 expression in both the nucleus and cytoplasm. Twenty of 36 (55%) MALT lymphomas lacking the translocation exhibited BCL10 expression in both the nucleus and cytoplasm although at a much lower level, whereas the remaining 16 cases displayed only cytoplasmic BCL10. Unlike MALT lymphoma, both follicular and mantle cell lymphomas generally displayed BCL10 expression compatible to their normal cell counterparts. Our results show differential expression of BCL10 protein among various B-cell populations of the B-cell follicle, indicating its importance in B-cell maturation. The subcellular localization of BCL10 was frequently altered in MALT lymphoma in comparison with its normal cell counterparts, suggesting that ectopic BCL10 expression may be important in the development of this type of tumor.
This article has been cited by other articles:
 |
|
 |
|
  S. Nakamura, H. Ye, C. M Bacon, A. Goatly, H. Liu, A. H Banham, R. Ventura, T. Matsumoto, M. Iida, Y. Ohji, et al. Clinical impact of genetic aberrations in gastric MALT lymphoma: a comprehensive analysis using interphase fluorescence in situ hybridisation Gut, October 1, 2007; 56(10): 1358 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zeng, L. Di, G. Fu, Y. Chen, X. Gao, L. Xu, X. Lin, and R. Wen Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated NF-{kappa}B Activation Mol. Cell. Biol., July 15, 2007; 27(14): 5235 - 5245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-S. Chuang, H. Liu, H. Ye, J. I Martin-Subero, R. Siebert, and W.-T. Huang Pulmonary mucosa-associated lymphoid tissue lymphoma with strong nuclear B-cell CLL/lymphoma 10 (BCL10) expression and novel translocation t(1;2)(p22;p12)/immunoglobulin {kappa} chain-BCL10 J. Clin. Pathol., June 1, 2007; 60(6): 727 - 728. [Full Text] [PDF]
|
|
|
|
|
|
C. M Bacon, M.-Q. Du, and A. Dogan Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists J. Clin. Pathol., April 1, 2007; 60(4): 361 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lobry, T. Lopez, A. Israel, and R. Weil Negative feedback loop in T cell activation through I{kappa}B kinase-induced phosphorylation and degradation of Bcl10 PNAS, January 16, 2007; 104(3): 908 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Suh, J. M. Crutchley, A. Koochek, A. Ryscavage, K. Bhat, T. Tanaka, A. Oshima, P. Fitzgerald, and S. H. Yuspa Reciprocal Modifications of CLIC4 in Tumor Epithelium and Stroma Mark Malignant Progression of Multiple Human Cancers Clin. Cancer Res., January 1, 2007; 13(1): 121 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M-Q Du and J C Atherton Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management. Gut, June 1, 2006; 55(6): 886 - 893. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Baens, S. Fevery, X. Sagaert, H. Noels, S. Hagens, V. Broeckx, A. D. Billiau, C. De Wolf-Peeters, and P. Marynen Selective Expansion of Marginal Zone B Cells in E{micro}-API2-MALT1 Mice Is Linked to Enhanced I{kappa}B Kinase {gamma} Polyubiquitination. Cancer Res., May 15, 2006; 66(10): 5270 - 5277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakagawa, Y. Hosokawa, M. Yonezumi, K. Izumiyama, R. Suzuki, S. Tsuzuki, M. Asaka, and M. Seto MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10 Blood, December 15, 2005; 106(13): 4210 - 4216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Salar, B. Bellosillo, S. Serrano, and C. Besses Persistent Residual Disease in t(11;18)(q21;q21) Positive Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Chemotherapy or Rituximab J. Clin. Oncol., October 10, 2005; 23(29): 7361 - 7362. [Full Text] [PDF]
|
|
|
|
|
|
M. T. Tian, G. Gonzalez, B. Scheer, and A. L. DeFranco Bcl10 can promote survival of antigen-stimulated B lymphocytes Blood, September 15, 2005; 106(6): 2105 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Farinha and R. D. Gascoyne Molecular Pathogenesis of Mucosa-Associated Lymphoid Tissue Lymphoma J. Clin. Oncol., September 10, 2005; 23(26): 6370 - 6378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bertoni and E. Zucca State-of-the-Art Therapeutics: Marginal-Zone Lymphoma J. Clin. Oncol., September 10, 2005; 23(26): 6415 - 6420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zucca and F. Bertoni Another Piece of the MALT Lymphomas Jigsaw J. Clin. Oncol., August 1, 2005; 23(22): 4832 - 4834. [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Yeh, S.-H. Kuo, L.-T. Chen, T.-L. Mao, S.-L. Doong, M.-S. Wu, H.-C. Hsu, Y.-S. Tzeng, C.-L. Chen, J.-T. Lin, et al. Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21) Blood, August 1, 2005; 106(3): 1037 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kuo, L.-T. Chen, K.-H. Yeh, M.-S. Wu, H.-C. Hsu, P.-Y. Yeh, T.-L. Mao, C.-L. Chen, S.-L. Doong, J.-T. Lin, et al. Nuclear Expression of BCL10 or Nuclear Factor Kappa B Predicts Helicobacter pylori-Independent Status of Early-Stage, High-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphomas J. Clin. Oncol., September 1, 2004; 22(17): 3491 - 3497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Holzmann, H. Kohlhammer, C. Schwaenen, S. Wessendorf, H. A. Kestler, A. Schwoerer, B. Rau, B. Radlwimmer, H. Dohner, P. Lichter, et al. Genomic DNA-Chip Hybridization Reveals a Higher Incidence of Genomic Amplifications in Pancreatic Cancer than Conventional Comparative Genomic Hybridization and Leads to the Identification of Novel Candidate Genes Cancer Res., July 1, 2004; 64(13): 4428 - 4433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Pileri, P. L. Zinzani, P. Went, A. Pileri Jr, and M. Bendandi Indolent lymphoma: the pathologist's viewpoint Ann. Onc., January 1, 2004; 15(1): 12 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Shen, A. C. T. Liang, L. Lu, W. Y. Au, K.-Y. Wong, P.-C. Tin, K.-W. Chan, K.-H. Ko, Y.-W. Chen, S.-L. Beh, et al. Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma Blood, August 15, 2003; 102(4): 1553 - 1554. [Full Text] [PDF]
|
|
|
|
|
|
H. Ye, H. Liu, A. Attygalle, A. C. Wotherspoon, A. G. Nicholson, F. Charlotte, V. Leblond, P. Speight, J. Goodlad, A. Lavergne-Slove, et al. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma Blood, August 1, 2003; 102(3): 1012 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sanchez-Izquierdo, G. Buchonnet, R. Siebert, R. D. Gascoyne, J. Climent, L. Karran, M. Marin, D. Blesa, D. Horsman, A. Rosenwald, et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma Blood, June 1, 2003; 101(11): 4539 - 4546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Kaneko, S Sakurai, M Hironaka, S Sato, S Oguni, Y Sakuma, K Sato, K Sugano, and K Saito Distinct methylated profiles in Helicobacter pylori dependent and independent gastric MALT lymphomas Gut, May 1, 2003; 52(5): 641 - 646. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Okabe, H. Inagaki, K. Ohshima, T. Yoshino, C. Li, T. Eimoto, R. Ueda, and S. Nakamura API2-MALT1 Fusion Defines a Distinctive Clinicopathologic Subtype in Pulmonary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Am. J. Pathol., April 1, 2003; 162(4): 1113 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ye, H. Liu, M. Raderer, A. Chott, A. Ruskone-Fourmestraux, A. Wotherspoon, M. J. S. Dyer, S.-S. Chuang, A. Dogan, P. G. Isaacson, et al. High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma Blood, April 1, 2003; 101(7): 2547 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sanchez-Beato, A. Sanchez-Aguilera, and M. A. Piris Cell cycle deregulation in B-cell lymphomas Blood, February 15, 2003; 101(4): 1220 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Maes, A. Demunter, B. Peeters, and C. De Wolf-Peeters BCL10 mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the API2-MLT fusion is associated with aberrant nuclear BCL10 expression Blood, February 15, 2002; 99(4): 1398 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, H. Ye, A. Dogan, R. Ranaldi, R. A. Hamoudi, I. Bearzi, P. G. Isaacson, and M.-Q. Du T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10 Blood, August 15, 2001; 98(4): 1182 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Harris, H. Stein, S. E. Coupland, M. Hummel, R. D. Favera, L. Pasqualucci, and W. C. Chan New Approaches to Lymphoma Diagnosis Hematology, January 1, 2001; 2001(1): 194 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cavalli, P. G. Isaacson, R. D. Gascoyne, and E. Zucca MALT Lymphomas Hematology, January 1, 2001; 2001(1): 241 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bertin, Y. Guo, L. Wang, S. M. Srinivasula, M. D. Jacobson, J.-L. Poyet, S. Merriam, M.-Q. Du, M. J. S. Dyer, K. E. Robison, et al. CARD9 Is a Novel Caspase Recruitment Domain-containing Protein That Interacts With BCL10/CLAP and Activates NF-kappa B J. Biol. Chem., December 22, 2000; 275(52): 41082 - 41086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bertin, L. Wang, Y. Guo, M. D. Jacobson, J.-L. Poyet, S. M. Srinivasula, S. Merriam, P. S. DiStefano, and E. S. Alnemri CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-kappa B J. Biol. Chem., April 6, 2001; 276(15): 11877 - 11882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, Y. Guo, W.-J. Huang, X. Ke, J.-L. Poyet, G. A. Manji, S. Merriam, M. A. Glucksmann, P. S. DiStefano, E. S. Alnemri, et al. CARD10 Is a Novel Caspase Recruitment Domain/Membrane-associated Guanylate Kinase Family Member That Interacts with BCL10 and Activates NF-kappa B J. Biol. Chem., June 8, 2001; 276(24): 21405 - 21409. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
