| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Warner-Lambert/Parke-Davis Award Lecture |
From The Burnham Institute, La Jolla, California
Abstract
Programmed cell death plays critical roles in a wide variety of physiological processes during fetal development and in adult tissues. In most cases, physiological cell death occurs by apoptosis as opposed to necrosis. Defects in apoptotic cell death regulation contribute to many diseases, including disorders where cell accumulation occurs (cancer, restenosis) or where cell loss ensues (stroke, heart failure, neurodegeneration, AIDS). In recent years, the molecular machinery responsible for apoptosis has been elucidated, revealing a family of intracellular proteases, the caspases, which are responsible directly or indirectly for the morphological and biochemical changes that characterize the phenomenon of apoptosis. Diverse regulators of the caspases have also been discovered, including activators and inhibitors of these cell death proteases. Inputs from signal transduction pathways into the core of the cell death machinery have also been identified, demonstrating ways of linking environmental stimuli to cell death responses or cell survival maintenance. Knowledge of the molecular mechanisms of apoptosis is providing insights into the causes of multiple pathologies where aberrant cell death regulation occurs and is beginning to provide new approaches to the treatment of human diseases.
This article has been cited by other articles:
 |
|
 |
|
  D. Zhai, C. Jin, Z. Huang, A. C. Satterthwait, and J. C. Reed Differential Regulation of Bax and Bak by Anti-apoptotic Bcl-2 Family Proteins Bcl-B and Mcl-1 J. Biol. Chem., April 11, 2008; 283(15): 9580 - 9586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Ray, S. Arab, Y. Deng, P. Liu, L. Penn, D. W. Courtman, and M. E. Ward Oxygen regulation of arterial smooth muscle cell proliferation and survival Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H839 - H852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Sigurdson, P. Bhatti, M. M. Doody, M. Hauptmann, L. Bowen, S. L. Simon, R. M. Weinstock, M. S. Linet, M. Rosenstein, M. Stovall, et al. Polymorphisms in Apoptosis- and Proliferation-Related Genes, Ionizing Radiation Exposure, and Risk of Breast Cancer among U.S. Radiologic Technologists Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2000 - 2007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. N. Obame, R. Zini, R. Souktani, A. Berdeaux, and D. Morin Peripheral Benzodiazepine Receptor-Induced Myocardial Protection is Mediated by Inhibition of Mitochondrial Membrane Permeabilization J. Pharmacol. Exp. Ther., October 1, 2007; 323(1): 336 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rajaraman, S. S. Wang, N. Rothman, M. M. Brown, P. M. Black, H. A. Fine, J. S. Loeffler, R. G. Selker, W. R. Shapiro, S. J. Chanock, et al. Polymorphisms in Apoptosis and Cell Cycle Control Genes and Risk of Brain Tumors in Adults Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1655 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Clark and A. T. Maurelli Shigella flexneri Inhibits Staurosporine-Induced Apoptosis in Epithelial Cells Infect. Immun., May 1, 2007; 75(5): 2531 - 2539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Kohlhaas, A. Craxton, X.-M. Sun, M. J. Pinkoski, and G. M. Cohen Receptor-mediated Endocytosis Is Not Required for Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis J. Biol. Chem., April 27, 2007; 282(17): 12831 - 12841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schubert-Unkmeir, O. Sokolova, U. Panzner, M. Eigenthaler, and M. Frosch Gene Expression Pattern in Human Brain Endothelial Cells in Response to Neisseria meningitidis Infect. Immun., February 1, 2007; 75(2): 899 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. van Geelen, J. L. Westra, E. G. de Vries, W. Boersma-van Ek, N. Zwart, H. Hollema, H. M. Boezen, N. H. Mulder, J. T. Plukker, S. de Jong, et al. Prognostic Significance of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Its Receptors in Adjuvantly Treated Stage III Colon Cancer Patients J. Clin. Oncol., November 1, 2006; 24(31): 4998 - 5004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Moorjani, M. Ahmad, P. Catarino, R. Brittin, D. Trabzuni, F. Al-Mohanna, N. Narula, J. Narula, and S. Westaby Activation of Apoptotic Caspase Cascade During the Transition to Pressure Overload-Induced Heart Failure J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1451 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Bartner, N. E. Robinson, M. Kiupel, and Y. Tesfaigzi Persistent mucus accumulation: a consequence of delayed bronchial mucous cell apoptosis in RAO-affected horses? Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L602 - L609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, E. Hinoi, A. Takemori, N. Nakamichi, and Y. Yoneda Glutamate Inhibits Chondral Mineralization through Apoptotic Cell Death Mediated by Retrograde Operation of the Cystine/Glutamate Antiporter J. Biol. Chem., August 25, 2006; 281(34): 24553 - 24565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Bhattacharyya, K. Pechhold, H. Shahjee, G. Zappala, C. Elbi, B. Raaka, M. Wiench, J. Hong, and M. M. Rechler Nonsecreted Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Can Induce Apoptosis in Human Prostate Cancer Cells by IGF-independent Mechanisms without Being Concentrated in the Nucleus J. Biol. Chem., August 25, 2006; 281(34): 24588 - 24601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Vera, K. Erkkila, C. Wang, C. Nunez, S. Kyttanen, Y. Lue, L. Dunkel, R. S. Swerdloff, and A. P. Sinha Hikim Involvement of p38 Mitogen-Activated Protein Kinase and Inducible Nitric Oxide Synthase in Apoptotic Signaling of Murine and Human Male Germ Cells after Hormone Deprivation Mol. Endocrinol., July 1, 2006; 20(7): 1597 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Aoudjit, A. Potapov, and T. Takano Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1534 - F1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Parfenova, S. Basuroy, S. Bhattacharya, D. Tcheranova, Y. Qu, R. F. Regan, and C. W. Leffler Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1399 - C1410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. K. Bhat, T. L. Sea, M. O. Olatinwo, D. Simorangkir, G. D. Ford, B. D. Ford, and D. R. Mann Influence of a Leptin Deficiency on Testicular Morphology, Germ Cell Apoptosis, and Expression Levels of Apoptosis-Related Genes in the Mouse J Androl, March 1, 2006; 27(2): 302 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cohen-Saidon, I. Carmi, A. Keren, and E. Razin Antiapoptotic function of Bcl-2 in mast cells is dependent on its association with heat shock protein 90beta Blood, February 15, 2006; 107(4): 1413 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Hao, T. Takano, J. Guillemette, J. Papillon, G. Ren, and A. V. Cybulsky Induction of Apoptosis by the Ste20-like Kinase SLK, a Germinal Center Kinase That Activates Apoptosis Signal-regulating Kinase and p38 J. Biol. Chem., February 10, 2006; 281(6): 3075 - 3084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Su, G. Wang, J. W. Barrett, T. S. Irvine, X. Gao, and G. McFadden Myxoma Virus M11L Blocks Apoptosis through Inhibition of Conformational Activation of Bax at the Mitochondria J. Virol., February 1, 2006; 80(3): 1140 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Z. Liu, L.-J. Yao, M.-X. Jiang, Z.-L. Lei, L.-S. Zhang, Y.-L. Zhang, Q.-Y. Sun, Y.-L. Zheng, X.-F. Song, and D.-Y. Chen Apoptosis in rabbit embryos produced by fertilization or nuclear transfer with fibroblasts and cumulus cells Reproduction, September 1, 2005; 130(3): 359 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Jain, A. Li, D. L. Nucatola, P. Minoo, and J. C. Felix Nonoxynol-9 Induces Apoptosis of Endometrial Explants by Both Caspase-Dependent and -Independent Apoptotic Pathways Biol Reprod, August 1, 2005; 73(2): 382 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. S. Hikim, Y. Vera, D. Vernet, M. Castanares, M. Diaz-Romero, M. Ferrini, R. S. Swerdloff, N. F. Gonzalez-Cadavid, and C. Wang Involvement of Nitric Oxide-Mediated Intrinsic Pathway Signaling in Age-Related Increase in Germ Cell Apoptosis in Male Brown-Norway Rats J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2005; 60(6): 702 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Choi, H.-J. Lee, S. Jee, S. Jin, S. K. Koo, S. S. Paik, S. C. Jung, S.-Y. Hwang, K. S. Lee, and B. Oh In Vitro Differentiation of Mouse Embryonic Stem Cells: Enrichment of Endodermal Cells in the Embryoid Body Stem Cells, June 1, 2005; 23(6): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhai, F. Luciano, X. Zhu, B. Guo, A. C. Satterthwait, and J. C. Reed Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak J. Biol. Chem., April 22, 2005; 280(16): 15815 - 15824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Vera, S. Rodriguez, M. Castanares, Y. Lue, V. Atienza, C. Wang, R. S. Swerdloff, and A. P. Sinha Hikim Functional Role of Caspases in Heat-Induced Testicular Germ Cell Apoptosis Biol Reprod, March 1, 2005; 72(3): 516 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Marconi, P. Atzei, C. Panza, C. Fila, R. Tiberio, F. Truzzi, T. Wachter, M. Leverkus, and C. Pincelli FLICE/caspase-8 activation triggers anoikis induced by {beta}1-integrin blockade in human keratinocytes J. Cell Sci., November 15, 2004; 117(24): 5815 - 5823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Drosten, G. Hilken, M. Bockmann, F. Rodicker, N. Mise, A. N. Cranston, U. Dahmen, B. A. J. Ponder, and B. M. Putzer Role of MEN2A-Derived RET in Maintenance and Proliferation of Medullary Thyroid Carcinoma J Natl Cancer Inst, August 18, 2004; 96(16): 1231 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Reed, K. S. Doctor, and A. Godzik The Domains of Apoptosis: A Genomics Perspective Sci. Signal., June 29, 2004; 2004(239): re9 - re9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Herbst and S. R. Frankel Oblimersen Sodium (Genasense bcl-2 Antisense Oligonucleotide): A Rational Therapeutic to Enhance Apoptosis in Therapy of Lung Cancer Clin. Cancer Res., June 15, 2004; 10(12): 4245S - 4248S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Kuijpers, N. A. Maianski, A. T. J. Tool, K. Becker, B. Plecko, F. Valianpour, R. J. A. Wanders, R. Pereira, J. Van Hove, A. J. Verhoeven, et al. Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis Blood, May 15, 2004; 103(10): 3915 - 3923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Seth, F. Diaz, J.-H. Tao-Cheng, and E. O. Major JC Virus Induces Nonapoptotic Cell Death of Human Central Nervous System Progenitor Cell-Derived Astrocytes J. Virol., May 1, 2004; 78(9): 4884 - 4891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Vera, M. Diaz-Romero, S. Rodriguez, Y. Lue, C. Wang, R. S. Swerdloff, and A. P. Sinha Hikim Mitochondria-Dependent Pathway Is Involved in Heat-Induced Male Germ Cell Death: Lessons from Mutant Mice Biol Reprod, May 1, 2004; 70(5): 1534 - 1540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Vertrees, R. Nason, M. D. Hold, A. M. Leeth, F. C. Schmalstieg, P. J. Boor, and J. B. Zwischenberger Smoke/Burn Injury-Induced Respiratory Failure Elicits Apoptosis in Ovine Lungs and Cultured Lung Cells, Ameliorated With Arteriovenous CO2 Removal Chest, April 1, 2004; 125(4): 1472 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. VAN EDEN, M. P. BYRD, K. W. SHERRILL, and R. E. LLOYD Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress RNA, March 1, 2004; 10(3): 469 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nagel-Wolfrum, C. Buerger, I. Wittig, K. Butz, F. Hoppe-Seyler, and B. Groner The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor Stat3 Inhibits Transactivation and Induces Apoptosis in Tumor Cells Mol. Cancer Res., March 1, 2004; 2(3): 170 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Bijian, T. Takano, J. Papillon, A. Khadir, and A. V. Cybulsky Extracellular matrix regulates glomerular epithelial cell survival and proliferation Am J Physiol Renal Physiol, February 1, 2004; 286(2): F255 - F266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Said, U. Paasch, H.-J. Glander, and A. Agarwal Role of caspases in male infertility Hum. Reprod. Update, January 1, 2004; 10(1): 39 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Stehlik, S. H. Lee, A. Dorfleutner, A. Stassinopoulos, J. Sagara, and J. C. Reed Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain Is a Regulator of Procaspase-1 Activation J. Immunol., December 1, 2003; 171(11): 6154 - 6163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tan and D. E. Hallahan Growth Factor-Independent Activation of Protein Kinase B Contributes to the Inherent Resistance of Vascular Endothelium to Radiation-Induced Apoptotic Response Cancer Res., November 15, 2003; 63(22): 7663 - 7667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cohen-Saidon, H. Nechushtan, S. Kahlon, N. Livni, A. Nissim, and E. Razin A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival Blood, October 1, 2003; 102(7): 2506 - 2512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. El-Bayoumy, B. A. Narayanan, D. H. Desai, N. K. Narayanan, B. Pittman, S. G. Amin, J. Schwartz, and D. W. Nixon Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray Carcinogenesis, September 1, 2003; 24(9): 1505 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stehlik, H. Hayashi, F. Pio, A. Godzik, and J. C. Reed CARD6 Is a Modulator of NF-{kappa}B Activation by Nod1- and Cardiak-mediated Pathways J. Biol. Chem., August 22, 2003; 278(34): 31941 - 31949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. S. Hikim, Y. Lue, C. M. Yamamoto, Y. Vera, S. Rodriguez, P. H. Yen, K. Soeng, C. Wang, and R. S. Swerdloff Key Apoptotic Pathways for Heat-Induced Programmed Germ Cell Death in the Testis Endocrinology, July 1, 2003; 144(7): 3167 - 3175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chatterjee, L. T. Bish, V. Jayasankar, A. S. Stewart, Y. J. Woo, M. T. Crow, T. J. Gardner, and H. L. Sweeney Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1461 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Reed, K. Doctor, A. Rojas, J. M. Zapata, C. Stehlik, L. Fiorentino, J. Damiano, W. Roth, S.-i. Matsuzawa, R. Newman, et al. Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans Genome Res., June 1, 2003; 13(6): 1376 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Bannerman and S. E. Goldblum Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L899 - L914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Li, M. D. Southall, Q. Yi, Y. Pei, D. Lewis, M. Al-Hassani, D. Spandau, and J. B. Travers The Epidermal Platelet-activating Factor Receptor Augments Chemotherapy-induced Apoptosis in Human Carcinoma Cell Lines J. Biol. Chem., May 2, 2003; 278(19): 16614 - 16621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Rainer, L. K.S. Wong, W. Lam, E. Yuen, N. Y.L. Lam, C. Metreweli, and Y.M. D. Lo Prognostic Use of Circulating Plasma Nucleic Acid Concentrations in Patients with Acute Stroke Clin. Chem., April 1, 2003; 49(4): 562 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Schimmer, I. M. Pedersen, S. Kitada, E. Eksioglu-Demiralp, M. D. Minden, R. Pinto, K. Mah, M. Andreeff, Y. Kim, W. S. Suh, et al. Functional Blocks in Caspase Activation Pathways Are Common in Leukemia and Predict Patient Response to Induction Chemotherapy Cancer Res., March 15, 2003; 63(6): 1242 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Moodley, P. Rigby, C. Bundell, S. Bunt, H. Hayashi, N. Misso, R. McAnulty, G. Laurent, A. Scaffidi, P. Thompson, et al. Macrophage Recognition and Phagocytosis of Apoptotic Fibroblasts Is Critically Dependent on Fibroblast-Derived Thrombospondin 1 and CD36 Am. J. Pathol., March 1, 2003; 162(3): 771 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Maianski, D. Roos, and T. W. Kuijpers Tumor necrosis factor alpha induces a caspase-independent death pathway in human neutrophils Blood, March 1, 2003; 101(5): 1987 - 1995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Allen, S. R. Florell, A. N. Hanks, A. Alexander, M. J. Diedrich, D. C. Altieri, and D. Grossman Survivin Expression in Mouse Skin Prevents Papilloma Regression and Promotes Chemical-induced Tumor Progression Cancer Res., February 1, 2003; 63(3): 567 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Richardson-Burns, B. K. Kleinschmidt-DeMasters, R. L. DeBiasi, and K. L. Tyler Progressive Multifocal Leukoencephalopathy and Apoptosis of Infected Oligodendrocytes in the Central Nervous System of Patients With and Without AIDS Arch Neurol, December 1, 2002; 59(12): 1930 - 1936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rosen, W. Shi, B. Calabretta, and J. Filmus Cell Detachment Triggers p38 Mitogen-activated Protein Kinase-dependent Overexpression of Fas Ligand. A NOVEL MECHANISM OF ANOIKIS OF INTESTINAL EPITHELIAL CELLS J. Biol. Chem., November 22, 2002; 277(48): 46123 - 46130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Lokshin, P. Kalinski, R. R. Sassi, R. B. Mailliard, J. Muller-Berghaus, W. J. Storkus, X. Peng, A. M. Marrangoni, R. P. Edwards, and E. Gorelik Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II Int. Immunol., September 1, 2002; 14(9): 1027 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. W. Rokhlin, R. A. Glover, A. F. Taghiyev, N. V. Guseva, R. E. B. Seftor, I. Shyshynova, A. V. Gudkov, and M. B. Cohen Bisindolylmaleimide IX Facilitates Tumor Necrosis Factor Receptor Family-mediated Cell Death and Acts as an Inhibitor of Transcription J. Biol. Chem., August 30, 2002; 277(36): 33213 - 33219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Eid, R. W. Lewis, and M. V. Kumar Mifepristone Pretreatment Overcomes Resistance of Prostate Cancer Cells to Tumor Necrosis Factor {alpha}-related Apoptosis-inducing Ligand (TRAIL) Mol. Cancer Ther., August 1, 2002; 1(10): 831 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kim, N. Suh, M. Sporn, and J. C. Reed An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis J. Biol. Chem., June 14, 2002; 277(25): 22320 - 22329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Eversole-Cire, J. Chen, and M. I. Simon Bax Is Not the Heterodimerization Partner Necessary for Sustained Anti-photoreceptor-Cell-Death Activity of Bcl-2 Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1636 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-F. Cartron, L. Oliver, S. Martin, C. Moreau, M.-T. LeCabellec, P. Jezequel, K. Meflah, and F. M. Vallette The expression of a new variant of the pro-apoptotic molecule Bax, Bax{psi}, is correlated with an increased survival of glioblastoma multiforme patients Hum. Mol. Genet., March 1, 2002; 11(6): 675 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sjostrom, C. Blomqvist, K. von Boguslawski, N.-O. Bengtsson, I. Mjaaland, P. Malmstrom, B. Ostenstadt, E. Wist, V. Valvere, S. Takayama, et al. The Predictive Value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for Chemotherapy Response in Advanced Breast Cancer Clin. Cancer Res., March 1, 2002; 8(3): 811 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
