help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Whitman, S. C.
Right arrow Articles by Daugherty, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Whitman, S. C.
Right arrow Articles by Daugherty, A.
(American Journal of Pathology. 2000;157:1819-1824.)
© 2000 American Society for Investigative Pathology

Short Communications

Exogenous Interferon-{gamma} Enhances Atherosclerosis in Apolipoprotein E-/- Mice

Stewart C. Whitman, Punnaivanam Ravisankar, Haley Elam and Alan Daugherty

From the Gill Heart Institute, Atherosclerosis Research Group, Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky

A role for interferon-{gamma} (IFN-{gamma}) has been implied in the atherogenic process. To determine whether exogenously administered IFN-{gamma} exerts an effect on the development of atherosclerosis, we intraperitoneally administered either recombinant IFN-{gamma} (100 U/g body weight) or phosphate buffered saline daily for 30 days to atherosclerosis-susceptible apolipoprotein E-/- mice (16-week-old male mice, n = 11 per group) fed a normal diet. Atherosclerotic lesion size was quantified in the ascending aorta. The number of T lymphocytes and major histocompatibility complex (MHC) class II-positive cells within lesions were also quantified in this region. IFN-{gamma} administration reduced serum cholesterol concentrations by 15% (P = 0.02). For both groups, the majority of cholesterol was present in very low density lipoproteins, which were modestly reduced in mice receiving IFN-{gamma}. Despite the decrease in serum cholesterol concentrations, IFN-{gamma} injections significantly increased lesion size twofold compared to controls (119,980 ± 18,536 vs. 59,396 ± 20,017 µm2; P = 0.038). IFN-{gamma} also significantly increased the mean number of T lymphocytes (19 ± 4 vs. 7 ± 1 cells; P = 0.03) and MHC class II-positive cells (10 ± 3 vs. 3 ± 1 cells; P = 0.04) within lesions. These data lend further support to a pro-atherogenic role of IFN-{gamma}.




This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. To, A. Agrotis, G. Besra, A. Bobik, and B.-H. Toh
NKT Cell Subsets Mediate Differential Proatherogenic Effects in ApoE-/- Mice
Arterioscler. Thromb. Vasc. Biol., May 1, 2009; 29(5): 671 - 677.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Z. Mallat, S. Taleb, H. Ait-Oufella, and A. Tedgui
The role of adaptive T cell immunity in atherosclerosis
J. Lipid Res., April 1, 2009; 50(Supplement): S364 - S369.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. T. Bolick, M. D. Skaflen, L. E. Johnson, S.-C. Kwon, D. Howatt, A. Daugherty, K. S. Ravichandran, and C. C. Hedrick
G2A Deficiency in Mice Promotes Macrophage Activation and Atherosclerosis
Circ. Res., February 13, 2009; 104(3): 318 - 327.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. de Nooijer, I. Bot, J.H. von der Thusen, M.A. Leeuwenburgh, H.S. Overkleeft, A.O. Kraaijeveld, R. Dorland, P.J. van Santbrink, S.H. van Heiningen, M.M. Westra, et al.
Leukocyte Cathepsin S Is a Potent Regulator of Both Cell and Matrix Turnover in Advanced Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., February 1, 2009; 29(2): 188 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
O. Ovchinnikova, A.-K. L. Robertson, D. Wagsater, E. J. Folco, M. Hyry, J. Myllyharju, P. Eriksson, P. Libby, and G. K. Hansson
T-Cell Activation Leads to Reduced Collagen Maturation in Atherosclerotic Plaques of Apoe-/- Mice
Am. J. Pathol., February 1, 2009; 174(2): 693 - 700.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
I. Gotsman, A. H. Sharpe, and A. H. Lichtman
T-Cell Costimulation and Coinhibition in Atherosclerosis
Circ. Res., November 21, 2008; 103(11): 1220 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. Vinuesa, A. Sola, M. Jung, V. Alfaro, and G. Hotter
Lipocalin-2-induced renal regeneration depends on cytokines
Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1554 - F1562.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Kisucka, A. K. Chauhan, I. S. Patten, A. Yesilaltay, C. Neumann, R. A. Van Etten, M. Krieger, and D. D. Wagner
Peroxiredoxin1 Prevents Excessive Endothelial Activation and Early Atherosclerosis
Circ. Res., September 12, 2008; 103(6): 598 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Kleemann, S. Zadelaar, and T. Kooistra
Cytokines and atherosclerosis: a comprehensive review of studies in mice
Cardiovasc Res, August 1, 2008; 79(3): 360 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
L. Rogers, S. Burchat, J. Gage, M. Hasu, M. Thabet, L. Wilcox, T. A. Ramsamy, and S. C. Whitman
Deficiency of invariant V{alpha}14 natural killer T cells decreases atherosclerosis in LDL receptor null mice
Cardiovasc Res, April 1, 2008; 78(1): 167 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. L. King, L. A. Cassis, and A. Daugherty
Interleukin-4 Does Not Influence Development of Hypercholesterolemia or Angiotensin II-Induced Atherosclerotic Lesions in Mice
Am. J. Pathol., December 1, 2007; 171(6): 2040 - 2047.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Ait-Oufella, B. Horvat, Y. Kerdiles, O. Herbin, P. Gourdy, J. Khallou-Laschet, R. Merval;, B. Esposito;, A. Tedgui, and Z. Mallat
Measles Virus Nucleoprotein Induces a Regulatory Immune Response and Reduces Atherosclerosis in Mice
Circulation, October 9, 2007; 116(15): 1707 - 1713.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
I. Gotsman and A. H. Lichtman
Targeting Interferon-{gamma} to Treat Atherosclerosis
Circ. Res., August 17, 2007; 101(4): 333 - 334.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Koga, H. Kai, H. Yasukawa, T. Yamamoto, Y. Kawai, S. Kato, K. Kusaba, M. Kai, K. Egashira, Y. Kataoka, et al.
Inhibition of Progression and Stabilization of Plaques by Postnatal Interferon-{gamma} Function Blocking in ApoE-Knockout Mice
Circ. Res., August 17, 2007; 101(4): 348 - 356.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Agrawal, M. Febbraio, E. Podrez, M. K. Cathcart, G. R. Stark, and G. M. Chisolm
Signal Transducer and Activator of Transcription 1 Is Required for Optimal Foam Cell Formation and Atherosclerotic Lesion Development
Circulation, June 12, 2007; 115(23): 2939 - 2947.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. N. Mitchell and P. Libby
Vascular Remodeling in Transplant Vasculopathy
Circ. Res., April 13, 2007; 100(7): 967 - 978.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. Tellides and J. S. Pober
Interferon-{gamma} Axis in Graft Arteriosclerosis
Circ. Res., March 16, 2007; 100(5): 622 - 632.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J.-R. Nofer, M. Bot, M. Brodde, P. J. Taylor, P. Salm, V. Brinkmann, T. van Berkel, G. Assmann, and E. A.L. Biessen
FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-Density Lipoprotein Receptor Deficient Mice
Circulation, January 30, 2007; 115(4): 501 - 508.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A.-K. L. Robertson and G. K Hansson
T Cells in Atherogenesis: For Better or For Worse?
Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2421 - 2432.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
G. Stoll and M. Bendszus
Inflammation and Atherosclerosis: Novel Insights Into Plaque Formation and Destabilization
Stroke, July 1, 2006; 37(7): 1923 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Chon, M. C. Verhaar, H. A. Koomans, J. A. Joles, and B. Braam
Role of Circulating Karyocytes in the Initiation and Progression of Atherosclerosis
Hypertension, May 1, 2006; 47(5): 803 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Tedgui and Z. Mallat
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Physiol Rev, April 1, 2006; 86(2): 515 - 581.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
X. Zhou, A.-K. L. Robertson, C. Hjerpe, and G. K. Hansson
Adoptive Transfer of CD4+ T Cells Reactive to Modified Low-Density Lipoprotein Aggravates Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., April 1, 2006; 26(4): 864 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. C. Dimayuga, H. Li, K.-Y. Chyu, G. N. Fredrikson, J. Nilsson, M. C. Fishbein, P. K. Shah, and B. Cercek
T Cell Modulation of Intimal Thickening After Vascular Injury: The Bimodal Role of IFN-{gamma} in Immune Deficiency
Arterioscler. Thromb. Vasc. Biol., December 1, 2005; 25(12): 2528 - 2534.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
S G Baidya and Q-T Zeng
Helper T cells and atherosclerosis: the cytokine web
Postgrad. Med. J., December 1, 2005; 81(962): 746 - 752.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. W. Feinberg, Z. Cao, A. K. Wara, M. A. Lebedeva, S. SenBanerjee, and M. K. Jain
Kruppel-like Factor 4 Is a Mediator of Proinflammatory Signaling in Macrophages
J. Biol. Chem., November 18, 2005; 280(46): 38247 - 38258.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. Ali, M. Middleton, E. Pure, and D. J. Rader
Apolipoprotein E Suppresses the Type I Inflammatory Response In Vivo
Circ. Res., October 28, 2005; 97(9): 922 - 927.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. Daugherty, N. R. Webb, D. L. Rateri, and V. L. King
Thematic review series: The Immune System and Atherogenesis. Cytokine regulation of macrophage functions in atherogenesis
J. Lipid Res., September 1, 2005; 46(9): 1812 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. J. Harvey and D. P. Ramji
Interferon-{gamma} and atherosclerosis: Pro- or anti-atherogenic?
Cardiovasc Res, July 1, 2005; 67(1): 11 - 20.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. P.J. de Winther, E. Kanters, G. Kraal, and M. H. Hofker
Nuclear Factor {kappa}B Signaling in Atherogenesis
Arterioscler. Thromb. Vasc. Biol., May 1, 2005; 25(5): 904 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. Tenger, A. Sundborger, J. Jawien, and X. Zhou
IL-18 Accelerates Atherosclerosis Accompanied by Elevation of IFN-{gamma} and CXCL16 Expression Independently of T Cells
Arterioscler. Thromb. Vasc. Biol., April 1, 2005; 25(4): 791 - 796.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
X. Zhou, A.-K. L. Robertson, M. Rudling, P. Parini, and G. K. Hansson
Lesion Development and Response to Immunization Reveal a Complex Role for CD4 in Atherosclerosis
Circ. Res., March 4, 2005; 96(4): 427 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. Md Sheikh, H. Ochi, A. Manabe, and J. Masuda
Lysophosphatidylcholine posttranscriptionally inhibits interferon-{gamma}-induced IP-10, Mig and I-Tac expression in endothelial cells
Cardiovasc Res, January 1, 2005; 65(1): 263 - 271.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. de Nooijer, J.H. von der Thusen, C.J.N. Verkleij, J. Kuiper, J.W. Jukema, E.E. van der Wall, Th.J.C. van Berkel, and E.A.L. Biessen
Overexpression of IL-18 Decreases Intimal Collagen Content and Promotes a Vulnerable Plaque Phenotype in Apolipoprotein-E-Deficient Mice
Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2313 - 2319.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Nakai, K. Iwabuchi, S. Fujii, N. Ishimori, N. Dashtsoodol, K. Watano, T. Mishima, C. Iwabuchi, S. Tanaka, J. S. Bezbradica, et al.
Natural killer T cells accelerate atherogenesis in mice
Blood, October 1, 2004; 104(7): 2051 - 2059.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. Mazzolai, M. A. Duchosal, M. Korber, K. Bouzourene, J. F. Aubert, H. Hao, V. Vallet, H. R. Brunner, J. Nussberger, G. Gabbiani, et al.
Endogenous Angiotensin II Induces Atherosclerotic Plaque Vulnerability and Elicits a Th1 Response in ApoE-/- Mice
Hypertension, September 1, 2004; 44(3): 277 - 282.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. G. Netea, B. J. Kullberg, L. E. H. Jacobs, T. J. G. Verver-Jansen, J. van der Ven-Jongekrijg, J. M. D. Galama, A. F. H. Stalenhoef, C. A. Dinarello, and J. W. M. Van der Meer
Chlamydia pneumoniae Stimulates IFN-{gamma} Synthesis through MyD88-Dependent, TLR2- and TLR4-Independent Induction of IL-18 Release
J. Immunol., July 15, 2004; 173(2): 1477 - 1482.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. H. Han, K. H. Hong, J. Ko, K. S. Rhee, M. K. Hong, J. J. Kim, Y. H. Kim, and S. J. Park
Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells
J. Leukoc. Biol., July 1, 2004; 76(1): 195 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. R. Portugal, L. R. Fernandes, G. C. Cesar, H. C. Santiago, D. R. Oliveira, N. M. Silva, A. A. Silva, J. Lannes-Vieira, R. M. E. Arantes, R. T. Gazzinelli, et al.
Infection with Toxoplasma gondii Increases Atherosclerotic Lesion in ApoE-Deficient Mice
Infect. Immun., June 1, 2004; 72(6): 3571 - 3576.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. F. Linton, A. S. Major, and S. Fazio
Proatherogenic Role for NK Cells Revealed
Arterioscler. Thromb. Vasc. Biol., June 1, 2004; 24(6): 992 - 994.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. C. Whitman, D. L. Rateri, S. J. Szilvassy, W. Yokoyama, and A. Daugherty
Depletion of Natural Killer Cell Function Decreases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice
Arterioscler. Thromb. Vasc. Biol., June 1, 2004; 24(6): 1049 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Hagihara, A. Higuchi, N. Tamura, Y. Ueda, K. Hirabayashi, Y. Ikeda, S. Kato, S. Sakamoto, T. Hotta, S. Handa, et al.
Platelets, after Exposure to a High Shear Stress, Induce IL-10-Producing, Mature Dendritic Cells In Vitro
J. Immunol., May 1, 2004; 172(9): 5297 - 5303.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Z. Chen, M. Sakuma, A. C. Zago, X. Zhang, C. Shi, L. Leng, Y. Mizue, R. Bucala, and D. I. Simon
Evidence for a Role of Macrophage Migration Inhibitory Factor in Vascular Disease
Arterioscler. Thromb. Vasc. Biol., April 1, 2004; 24(4): 709 - 714.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. M. Wuttge, X. Zhou, Y. Sheikine, D. Wagsater, V. Stemme, U. Hedin, S. Stemme, G. K. Hansson, and A. Sirsjo
CXCL16/SR-PSOX Is an Interferon-{gamma}-Regulated Chemokine and Scavenger Receptor Expressed in Atherosclerotic Lesions
Arterioscler. Thromb. Vasc. Biol., April 1, 2004; 24(4): 750 - 755.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. S. Burnett, S. Durrani, E. Stabile, M. Saji, C. W. Lee, T. D. Kinnaird, E. P. Hoffman, and S. E. Epstein
Murine Cytomegalovirus Infection Increases Aortic Expression of Proatherosclerotic Genes
Circulation, February 24, 2004; 109(7): 893 - 897.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Gojova, V. Brun, B. Esposito, F. Cottrez, P. Gourdy, P. Ardouin, A. Tedgui, Z. Mallat, and H. Groux
Specific abrogation of transforming growth factor-{beta} signaling in T cells alters atherosclerotic lesion size and composition in mice
Blood, December 1, 2003; 102(12): 4052 - 4058.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
O. J de Boer, A. E Becker, and A. C van der Wal
T lymphocytes in atherogenesis--functional aspects and antigenic repertoire
Cardiovasc Res, October 15, 2003; 60(1): 78 - 86.
[Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. OSTERUD and E. BJORKLID
Role of Monocytes in Atherogenesis
Physiol Rev, October 1, 2003; 83(4): 1069 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
Z. Mallat, A. Gojova, V. Brun, B. Esposito, N. Fournier, F. Cottrez, A. Tedgui, and H. Groux
Induction of a Regulatory T Cell Type 1 Response Reduces the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice
Circulation, September 9, 2003; 108(10): 1232 - 1237.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. A. Reardon, L. Blachowicz, J. Lukens, M. Nissenbaum, and G. S. Getz
Genetic Background Selectively Influences Innominate Artery Atherosclerosis: Immune System Deficiency as a Probe
Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1449 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Benagiano, A. Azzurri, A. Ciervo, A. Amedei, C. Tamburini, M. Ferrari, J. L. Telford, C. T. Baldari, S. Romagnani, A. Cassone, et al.
T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions
PNAS, May 27, 2003; 100(11): 6658 - 6663.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Y. Stokes, E. C. Clanton, K. P. Clements, and D. N. Granger
Role of Interferon-{gamma} in Hypercholesterolemia-Induced Leukocyte-Endothelial Cell Adhesion
Circulation, April 29, 2003; 107(16): 2140 - 2145.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. Buono, C. E. Come, G. Stavrakis, G. F. Maguire, P. W. Connelly, and A. H. Lichtman
Influence of Interferon-{gamma} on the Extent and Phenotype of Diet-Induced Atherosclerosis in the LDLR-Deficient Mouse
Arterioscler. Thromb. Vasc. Biol., March 1, 2003; 23(3): 454 - 460.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. R. Webb, M. A. Bostrom, S. J. Szilvassy, D. R. van der Westhuyzen, A. Daugherty, and F. C. de Beer
Macrophage-Expressed Group IIA Secretory Phospholipase A2 Increases Atherosclerotic Lesion Formation in LDL Receptor-Deficient Mice
Arterioscler. Thromb. Vasc. Biol., February 1, 2003; 23(2): 263 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. Kalinina, A. Agrotis, E. Tararak, Y. Antropova, P. Kanellakis, O. Ilyinskaya, M. T. Quinn, V. Smirnov, and A. Bobik
Cytochrome b558-Dependent NAD(P)H Oxidase-Phox Units in Smooth Muscle and Macrophages of Atherosclerotic Lesions
Arterioscler. Thromb. Vasc. Biol., December 1, 2002; 22(12): 2037 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. S. Major, S. Fazio, and M. F. Linton
B-Lymphocyte Deficiency Increases Atherosclerosis in LDL Receptor-Null Mice
Arterioscler. Thromb. Vasc. Biol., November 1, 2002; 22(11): 1892 - 1898.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Kozaki, W. E. Kaminski, J. Tang, S. Hollenbach, P. Lindahl, C. Sullivan, J.-C. Yu, K. Abe, P. J. Martin, R. Ross, et al.
Blockade of Platelet-Derived Growth Factor or Its Receptors Transiently Delays but Does Not Prevent Fibrous Cap Formation in ApoE Null Mice
Am. J. Pathol., October 1, 2002; 161(4): 1395 - 1407.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. K. Hansson, P. Libby, U. Schonbeck, and Z.-Q. Yan
Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis
Circ. Res., August 23, 2002; 91(4): 281 - 291.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
U. Schonbeck, G. K. Sukhova, N. Gerdes, and P. Libby
TH2 Predominant Immune Responses Prevail in Human Abdominal Aortic Aneurysm
Am. J. Pathol., August 1, 2002; 161(2): 499 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Daugherty and D. L. Rateri
T Lymphocytes in Atherosclerosis: The Yin-Yang of Th1 and Th2 Influence on Lesion Formation
Circ. Res., May 31, 2002; 90(10): 1039 - 1040.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
L. J. Pinderski, M. P. Fischbein, G. Subbanagounder, M. C. Fishbein, N. Kubo, H. Cheroutre, L. K. Curtiss, J. A. Berliner, and W. A. Boisvert
Overexpression of Interleukin-10 by Activated T Lymphocytes Inhibits Atherosclerosis in LDL Receptor-Deficient Mice by Altering Lymphocyte and Macrophage Phenotypes
Circ. Res., May 31, 2002; 90(10): 1064 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Agrawal, M. L. Agarwal, M. Chatterjee-Kishore, G. R. Stark, and G. M. Chisolm
Stat1-Dependent, p53-Independent Expression of p21waf1 Modulates Oxysterol-Induced Apoptosis
Mol. Cell. Biol., April 1, 2002; 22(7): 1981 - 1992.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
G. K. Hansson
The B Cell: A Good Guy in Vascular Disease?
Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 523 - 524.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. Dimayuga, B. Cercek, S. Oguchi, G. N. Fredrikson, J. Yano, P. K. Shah, S. Jovinge, and J. Nilsson
Inhibitory Effect on Arterial Injury-Induced Neointimal Formation by Adoptive B-Cell Transfer in Rag-1 Knockout Mice
Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 644 - 649.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
V. L. King, S. J. Szilvassy, and A. Daugherty
Interleukin-4 Deficiency Decreases Atherosclerotic Lesion Formation in a Site-Specific Manner in Female LDL Receptor-/- Mice
Arterioscler. Thromb. Vasc. Biol., March 1, 2002; 22(3): 456 - 461.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B. R. Kwak, S. Myit, F. Mulhaupt, N. Veillard, N. Rufer, E. Roosnek, and F. Mach
PPAR{gamma} but not PPAR{alpha} Ligands Are Potent Repressors of Major Histocompatibility Complex Class II Induction in Atheroma-Associated Cells
Circ. Res., February 22, 2002; 90(3): 356 - 362.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. C. Whitman, P. Ravisankar, and A. Daugherty
Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E-/- Mice Through Release of Interferon-{gamma}
Circ. Res., February 8, 2002; 90 (2): e34 - e38.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
N. Gerdes, G. K. Sukhova, P. Libby, R. S. Reynolds, J. L. Young, and U. Schonbeck
Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages: Implications for Atherogenesis
J. Exp. Med., January 22, 2002; 195(2): 245 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
G. K. Hansson
Immune Mechanisms in Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., December 1, 2001; 21(12): 1876 - 1890.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. C. Whitman, P. Ravisankar, and A. Daugherty
Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E-/- Mice Through Release of Interferon-{gamma}
Circ. Res., February 8, 2002; 90 (2): e34 - e38.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B. R. Kwak, S. Myit, F. Mulhaupt, N. Veillard, N. Rufer, E. Roosnek, and F. Mach
PPAR{gamma} but not PPAR{alpha} Ligands Are Potent Repressors of Major Histocompatibility Complex Class II Induction in Atheroma-Associated Cells
Circ. Res., February 22, 2002; 90(3): 356 - 362.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. Dimayuga, B. Cercek, S. Oguchi, G. N. Fredrikson, J. Yano, P. K. Shah, S. Jovinge, and J. Nilsson
Inhibitory Effect on Arterial Injury-Induced Neointimal Formation by Adoptive B-Cell Transfer in Rag-1 Knockout Mice
Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 644 - 649.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Society for Investigative Pathology.