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(American Journal of Pathology. 2000;157:1825-1827.)
© 2000 American Society for Investigative Pathology

Short Communications

Molecular Evidence for Multicentric Development of Thyroid Carcinomas in Patients with Familial Adenomatous Polyposis

Michiko Miyaki*{dagger}, Takeru Iijima*{dagger}, Reiko Ishii*, Tsunekazu Hishima{ddagger}, Takeo Mori§, Keigo Yoshinaga, Hiroshi Takami||, Toshio Kuroki{dagger} and Takeo Iwama**

From the Hereditary Tumor Research Project,*
Department of Pathology,{ddagger}
Department of Surgery,§
Tokyo Metropolitan Komagome Hospital; Tokyo Medical and Dental University; Teikyo University;||
Institute of Molecular Oncology;{dagger}
Showa University; and Kyoundo Hospital,**
Sasaki Institute, Tokyo, Japan

Familial adenomatous polyposis is characterized by multiple colorectal adenomas and an increased incidence of colorectal carcinomas. Patients also develop various extracolonic tumors, of which, thyroid carcinoma is common in young females. The occurrence of multiple carcinomas in one thyroid is frequently observed, although some carcinomas are solitary. To clarify whether each carcinoma develops independently or metastatically spreads from the first one formed, we analyzed the adenomatous polyposis coli (APC) gene mutation in each carcinoma. We found that each carcinoma had a different somatic mutation of the APC gene. This is molecular confirmation for the multicentric development of thyroid carcinomas in familial adenomatous polyposis through biallelic inactivation of the APC gene.






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Copyright © 2000 by the American Society for Investigative Pathology.