| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
by Influenza Hemagglutinin-Specific CD8 Effector T Cells Influences the Development of Pulmonary Immunopathology
From the Trudeau Institute,*
Saranac Lake, New York; the
Immunobiology Department,
DNAX Research
Institute, Palo Alto, California; and the College of Veterinary
Medicine,
Michigan State University, East
Lansing, Michigan
This study examined the inflammation, lung
function impairment, and immune protection associated with
either wild-type or interferon (IFN)-
-deficient Tc1- or Tc2-CD8
effector cells responding to influenza pneumonia. The adoptive transfer
of influenza hemagglutinin-specific Tc1 effectors afforded protection
and elicited only minimal impairment of lung function.
IFN--deficient Tc1 effector cells were equally protective,
but were associated with an eosinophil influx and slightly more lung
function impairment early in the response. Relative to Tc1, Tc2
effector cells were less protective, elicited an eosinophil
influx and a greater impairment of lung functions. IFN--deficient
Tc2 effector cells were not protective and were associated with the
severest impairment of lung function throughout the response,
an accumulation of neutrophils, and extensive pulmonary
vasculitis and alveolar hemorrhaging. Deletion of IFN- was
associated with a delay in effector cell recruitment and the
elicitation of a more intense inflammatory response that resulted in
more severe lung function impairment in the recipients of either
Tc1 or Tc2 IFN--deficient effector cells. Thus, during
influenza infections, IFN- production by the responding CD8
T cells is associated with effector cell recruitment and mitigation of
the associated inflammation and of the resulting impairment in lung
functions but is not necessary for optimal protection.
This article has been cited by other articles:
 |
|
 |
|
  J. Chen, Y. F. Lau, E. W. Lamirande, C. D. Paddock, J. H. Bartlett, S. R. Zaki, and K. Subbarao Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection J. Virol., February 1, 2010; 84(3): 1289 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Crowe, K. Chen, D. A. Pociask, J. F. Alcorn, C. Krivich, R. I. Enelow, T. M. Ross, J. L. Witztum, and J. K. Kolls Critical Role of IL-17RA in Immunopathology of Influenza Infection J. Immunol., October 15, 2009; 183(8): 5301 - 5310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Khoufache, F. LeBouder, E. Morello, F. Laurent, S. Riffault, P. Andrade-Gordon, S. Boullier, P. Rousset, N. Vergnolle, and B. Riteau Protective Role for Protease-Activated Receptor-2 against Influenza Virus Pathogenesis via an IFN-{gamma}-Dependent Pathway J. Immunol., June 15, 2009; 182(12): 7795 - 7802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Brincks, A. Katewa, T. A. Kucaba, T. S. Griffith, and K. L. Legge CD8 T Cells Utilize TRAIL to Control Influenza Virus Infection J. Immunol., October 1, 2008; 181(7): 4918 - 4925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. You, M. Ripple, S. Balakrishna, D. Troxclair, D. Sandquist, L. Ding, T. A. Ahlert, and S. A. Cormier Inchoate CD8+ T Cell Responses in Neonatal Mice Permit Influenza-Induced Persistent Pulmonary Dysfunction J. Immunol., September 1, 2008; 181(5): 3486 - 3494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wiley and A. G. Harmsen Pneumocystis Infection Enhances Antibody-Mediated Resistance to a Subsequent Influenza Infection J. Immunol., April 15, 2008; 180(8): 5613 - 5624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-S. Quan, R. W. Compans, H. H. Nguyen, and S.-M. Kang Induction of Heterosubtypic Immunity to Influenza Virus by Intranasal Immunization J. Virol., February 1, 2008; 82(3): 1350 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Buchweitz, J. R. Harkema, and N. E. Kaminski Time-Dependent Airway Epithelial and Inflammatory Cell Responses Induced by Influenza Virus A/PR/8/34 in C57BL/6 Mice Toxicol Pathol, April 1, 2007; 35(3): 424 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Brown, A. M. Dilzer, D. L. Meents, and S. L. Swain CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J. Immunol., September 1, 2006; 177(5): 2888 - 2898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hollenbaugh and R. W. Dutton IFN-{gamma} Regulates Donor CD8 T Cell Expansion, Migration, and Leads to Apoptosis of Cells of a Solid Tumor. J. Immunol., September 1, 2006; 177(5): 3004 - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Reyes, A. Prieto, A. de la Hera, P. de Lucas, R. Alvarez-Sala, J. L. Alvarez-Sala, and M. Alvarez-Mon Treatment With AM3 Restores Defective T-Cell Function in COPD Patients Chest, March 1, 2006; 129(3): 527 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Meissner, F. E. Lund, S. Han, and A. Harmsen CD8 T Cell-Mediated Lung Damage in Response to the Extracellular Pathogen Pneumocystis Is Dependent on MHC Class I Expression by Radiation-Resistant Lung Cells J. Immunol., December 15, 2005; 175(12): 8271 - 8279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wiley, M. P. Tighe, and A. G. Harmsen Upper Respiratory Tract Resistance to Influenza Infection Is Not Prevented by the Absence of Either Nasal-Associated Lymphoid Tissue or Cervical Lymph Nodes J. Immunol., September 1, 2005; 175(5): 3186 - 3196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Mayer, K. Mohrs, S. R. Crowe, L. L. Johnson, P. Rhyne, D. L. Woodland, and M. Mohrs The Functional Heterogeneity of Type 1 Effector T Cells in Response to Infection Is Related to the Potential for IFN-{gamma} Production J. Immunol., June 15, 2005; 174(12): 7732 - 7739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xu, H. Yoon, M. Q. Zhao, J. Liu, C. V. Ramana, and R. I. Enelow Cutting Edge: Pulmonary Immunopathology Mediated by Antigen-Specific Expression of TNF-{alpha} by Antiviral CD8+ T Cells J. Immunol., July 15, 2004; 173(2): 721 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Lawrence and T. J. Braciale Activation, Differentiation, and Migration of Naive Virus-Specific CD8+ T Cells during Pulmonary Influenza Virus Infection J. Immunol., July 15, 2004; 173(2): 1209 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wiley, R. J. Hogan, D. L. Woodland, and A. G. Harmsen Antigen-Specific CD8+ T Cells Persist in the Upper Respiratory Tract Following Influenza Virus Infection J. Immunol., September 15, 2001; 167(6): 3293 - 3299. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
