This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ge, Y. Articles by Kitamura, Y. Search for Related Content PubMed PubMed Citation Articles by Ge, Y. Articles by Kitamura, Y.

(American Journal of Pathology. 2001;158:281-292.)
© 2001 American Society for Investigative Pathology

Regular Articles

Independent Influence of Strain Difference and mi Transcription Factor on the Expression of Mouse Mast Cell Chymases

Yi Ge^*, Tomoko Jippo^*, Young-Mi Lee^*, Shiro Adachi^* and Yukihiko Kitamura^*

From the Department of Pathology,^*
Osaka University Medical School, Suita, Japan; and the Department of Oriental Pharmacy,
College of Pharmacy, Wonkwang University, Chonbuk, Republic of Korea

Expression of mouse mast cell protease (mMCP) genes was examined with particular attention to the transactivation effect of mi transcription factor (MITF) and the expression differences between C57BL/6 (B6) and WB strains. We had reported the enhancing effect of MITF on the expression of mMCP-4, -5, and -6 genes in cultured mast cells (CMCs) of B6 strain, and in the present study we demonstrated the enhancing effect on the expression of mMCP-2 and -9 genes as well. The enhancing effect of MITF on the expression of mMCP-2, -4, -5, -6, and -9 genes was also detected in CMCs of the WB strain. The regulation of mMCP-2, -4, and -9 genes was localized to a specific promoter element (CANNTG) which was recognized and bound by MITF and which was conserved between the B6 and WB strains. On the other hand, the expression of mMCP-2, -4, and -9 genes was smaller in CMCs of the B6 strain when compared to their expression in CMCs of the WB strain. Although mMCP-5 is a chymase as mMCP-2, -4, and -9, and genes encoding all of the chymases are located on chromosome 14, the mMCP-5 gene was regulated in a manner distinct from mMCP-2, -4, and -9 genes.

This article has been cited by other articles:

				N. A. Meadows, S. M. Sharma, G. J. Faulkner, M. C. Ostrowski, D. A. Hume, and A. I. Cassady The Expression of Clcn7 and Ostm1 in Osteoclasts Is Coregulated by Microphthalmia Transcription Factor J. Biol. Chem., January 19, 2007; 282(3): 1891 - 1904. [Abstract] [Full Text] [PDF]

				E. Tchougounova, G. Pejler, and M. Abrink The Chymase, Mouse Mast Cell Protease 4, Constitutes the Major Chymotrypsin-like Activity in Peritoneum and Ear Tissue. A Role for Mouse Mast Cell Protease 4 in Thrombin Regulation and Fibronectin Turnover J. Exp. Med., August 4, 2003; 198(3): 423 - 431. [Abstract] [Full Text] [PDF]

				T. Jippo, E. Morii, A. Ito, and Y. Kitamura Effect of Anatomical Distribution of Mast Cells on Their Defense Function against Bacterial Infections: Demonstration Using Partially Mast Cell-deficient tg/tg Mice J. Exp. Med., June 2, 2003; 197(11): 1417 - 1425. [Abstract] [Full Text] [PDF]

				A. Ito, T. Jippo, T. Wakayama, E. Morii, Y.-i. Koma, H. Onda, H. Nojima, S. Iseki, and Y. Kitamura SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF Blood, April 1, 2003; 101(7): 2601 - 2608. [Abstract] [Full Text] [PDF]

				E. Morii, K. Oboki, T. Jippo, and Y. Kitamura Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells Blood, February 15, 2003; 101(4): 1344 - 1350. [Abstract] [Full Text] [PDF]