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(American Journal of Pathology. 2001;158:1217-1222.)
© 2001 American Society for Investigative Pathology

Short Communications

Growth Hormone Receptor Is Expressed in Human Breast Cancer

Maria Gebre-Medhin^*, Lars-Gunnar Kindblom, Håkan Wennbo, Jan Törnell^* and Jeanne M. Meis-Kindblom

From the Department of Physiology and Pharmacology^*
and the Department of Pathology,
Lundberg Laboratory for Cancer Research, Göteborg University, Göteborg; and AstraZeneca,
R&D Mölndal, Mölndal, Sweden

Several clinical observations and experimental studies indicate that pituitary hormones, including growth hormone, play a role in the development of human breast cancer. We analyzed 48 human breast carcinomas using reverse transcription polymerase chain reaction, immunohistochemistry, and Western blotting techniques to assess growth hormone receptor expression. In 17 of these cases, adjacent normal breast tissue was similarly analyzed. These analyses revealed that growth hormone receptor (GHR) is expressed in human breast cancer and appears to be up-regulated compared to adjacent normal breast tissue. GHR expression correlated inversely with tumor grade and MIB-1 index. Progesterone receptor expression correlated positively with GHR expression. These findings, along with our observation of GHR expression in breast cancer stromal cells and previous reports of local production of growth hormone in breast carcinoma, suggest that GHR-mediated signaling pathways are involved in the development of human breast cancer, possibly via autocrine or paracrine mechanisms.

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