| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Departments of Pathology and Laboratory
Medicine,
Veterans Affairs Medical Center, Ann
Arbor; and the Department of Pathology,*
University of
Michigan Hospitals, Ann Arbor, Michigan
Transcript expression of 24 chemokines (CKs) was examined
throughout 8 days in mouse lungs with type-1 (Th1) or type-2 (Th2)
cytokine-mediated granulomas induced by bead-immobilized mycobacterial
purified protein derivative or Schistosoma mansoni egg
antigens. Where possible, CK protein levels were also measured.
In addition, we examined effects of in vivo
cytokine depletions. Findings were as follows: 1) bead challenge
induced increases in 18 of 24 CK transcripts with type-1 and type-2
responses displaying different patterns. CKs fell into four categories:
a) type-1-dominant (
-interferon-inducible protein (IP-10),
monokine induced by INF- (MIG), macrophage inflammatory
protein-2 (MIP-2), lipopolysaccharide-induced chemokine
(LIX), rodent growth-related oncogene homologue (KP),
macrophage inflammatory protein-1
(MIP-1) and -1ß
(MIP-1ß), lymphotactin), b) type-2-dominant
(eotaxin, monocyte chemotactic protein-2 (MCP-2) and -3
(MCP-3), liver and activation-regulated chemokine
(LARC), T cell activation protein-3 (TCA-3), c) type-1
and type-2 co-dominant (MCP-1, MCP-5,
monocyte-derived chemokine (MDC), thymus and
activation-related chemokine (TARC), C10), and d)
constitutive (lungkine, secondary lymphoid-tissue chemokine
(SLC), EBI1-ligand chemokine (ELC),
fractalkine, macrophage inflammatory protein-1
(MIP1-), and stromal cell derived factor-1 (SDF1-). 2)
CKs displayed characteristic temporal patterns. CXC (IP-10,
MIG, MIP-2, LIX, KC) and certain CC
(MCP-1, MCP-5, MIP-1, MIP-1ß) CKs were
produced maximally within 1 to 2 days. Others (MCP-2,
MCP-3, eotaxin, lymphotactin, LARC,
TCA-3) displayed peak expression later. 3) Interferon-
neutralization profoundly abrogated MIG, but had little effect
on other CKs. Tumor necrosis factor- neutralization caused up to
50% reduction in a range of CKs. These findings indicate that type-1
and type-2 granulomas display characteristic CK profiles with
coordinated expression that is under cytokine-mediated
regulation.
This article has been cited by other articles:
 |
|
 |
|
  J. Lim, S. C. Derrick, K. Kolibab, A. L. Yang, S. Porcelli, W. R. Jacobs, and S. L. Morris Early Pulmonary Cytokine and Chemokine Responses in Mice Immunized with Three Different Vaccines against Mycobacterium tuberculosis Determined by PCR Array Clin. Vaccine Immunol., January 1, 2009; 16(1): 122 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ruhwald, T. Bodmer, C. Maier, M. Jepsen, M. B. Haaland, J. Eugen-Olsen, P. Ravn, and on behalf of TBNET Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis Eur. Respir. J., December 1, 2008; 32(6): 1607 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Chaitra, M. S. Shaila, and R. Nayak Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis J. Med. Microbiol., September 1, 2008; 57(9): 1079 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lei, B. L. Plattner, and J. M. Hostetter Live Mycobacterium avium subsp. paratuberculosis and a Killed-Bacterium Vaccine Induce Distinct Subcutaneous Granulomas, with Unique Cellular and Cytokine Profiles Clin. Vaccine Immunol., May 1, 2008; 15(5): 783 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Facco, I. Baesso, M. Miorin, M. Bortoli, A. Cabrelle, E. Boscaro, C. Gurrieri, L. Trentin, R. Zambello, F. Calabrese, et al. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis J. Leukoc. Biol., October 1, 2007; 82(4): 946 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Phadke, G. Akangire, S. J. Park, S. A. Lira, and B. Mehrad The Role of CC Chemokine Receptor 6 in Host Defense in a Model of Invasive Pulmonary Aspergillosis Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1165 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Hogan, D. O. Co, J. Karman, E. Heninger, M. Suresh, and M. Sandor Virally Activated CD8 T Cells Home to Mycobacterium bovis BCG-Induced Granulomas but Enhance Antimycobacterial Protection Only in Immunodeficient Mice Infect. Immun., March 1, 2007; 75(3): 1154 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Van Ginderachter, S. Meerschaut, Y. Liu, L. Brys, K. De Groeve, G. Hassanzadeh Ghassabeh, G. Raes, and P. De Baetselier Peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer Blood, July 15, 2006; 108(2): 525 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wen, C. M. Hogaboam, J. Gauldie, and S. L. Kunkel Severe Sepsis Exacerbates Cell-Mediated Immunity in the Lung Due to an Altered Dendritic Cell Cytokine Profile Am. J. Pathol., June 1, 2006; 168(6): 1940 - 1950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Weigt, C. Nassenstein, T. Tschernig, P. F. Muhlradt, N. Krug, and A. Braun Efficacy of Macrophage-activating Lipopeptide-2 Combined with Interferon-{gamma} in a Murine Asthma Model Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 566 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. S. Souza, E. Roffe, V. Pinho, D. G. Souza, A. F. Silva, R. C. Russo, R. Guabiraba, C. A. J. Pereira, F. M. Carvalho, M. M. Barsante, et al. Potential Role of the Chemokine Macrophage Inflammatory Protein 1{alpha} in Human and Experimental Schistosomiasis Infect. Immun., April 1, 2005; 73(4): 2515 - 2523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Chiu, C. M. Freeman, V. R. Stolberg, J. S. Hu, K. Zeibecoglou, B. Lu, C. Gerard, I. F. Charo, S. A. Lira, and S. W. Chensue Impaired Lung Dendritic Cell Activation in CCR2 Knockout Mice Am. J. Pathol., October 1, 2004; 165(4): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jakubzick, H. Wen, A. Matsukawa, M. Keller, S. L. Kunkel, and C. M. Hogaboam Role of CCR4 Ligands, CCL17 and CCL22, During Schistosoma mansoni Egg-Induced Pulmonary Granuloma Formation in Mice Am. J. Pathol., October 1, 2004; 165(4): 1211 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishiwaki, H. Yoneyama, Y. Eishi, N. Matsuo, K. Tatsumi, H. Kimura, T. Kuriyama, and K. Matsushima Indigenous Pulmonary Propionibacterium acnes Primes the Host in the Development of Sarcoid-Like Pulmonary Granulomatosis in Mice Am. J. Pathol., August 1, 2004; 165(2): 631 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Chiu, C. M. Freeman, V. R. Stolberg, J. S. Hu, E. Komuniecki, and S. W. Chensue The Innate Pulmonary Granuloma: Characterization and Demonstration of Dendritic Cell Recruitment and Function Am. J. Pathol., March 1, 2004; 164(3): 1021 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Stavitsky Regulation of Granulomatous Inflammation in Experimental Models of Schistosomiasis Infect. Immun., January 1, 2004; 72(1): 1 - 12. [Full Text] [PDF]
|
|
|
|
|
|
C. L. Fuller, J. L. Flynn, and T. A. Reinhart In Situ Study of Abundant Expression of Proinflammatory Chemokines and Cytokines in Pulmonary Granulomas That Develop in Cynomolgus Macaques Experimentally Infected with Mycobacterium tuberculosis Infect. Immun., December 1, 2003; 71(12): 7023 - 7034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Buza, Y. Mori, A. M. Bari, H. Hikono Aodon-geril, S. Hirayama, Y. Shu, and E. Momotani Mycobacterium avium subsp. paratuberculosis Infection Causes Suppression of RANTES, Monocyte Chemoattractant Protein 1, and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle Infect. Immun., December 1, 2003; 71(12): 7223 - 7227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Helmby and R. K. Grencis IFN-{gamma}-Independent Effects of IL-12 During Intestinal Nematode Infection J. Immunol., October 1, 2003; 171(7): 3691 - 3696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, Q. Chen, D. M. Hoover, P. Staley, K. D. Tucker, J. Lubkowski, and J. J. Oppenheim Many chemokines including CCL20/MIP-3{alpha} display antimicrobial activity J. Leukoc. Biol., September 1, 2003; 74(3): 448 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. T. Kozma, G. Losonczy, M. Keszei, Z. Komlosi, E. Buzas, E. Pallinger, J. Appel, T. Szabo, P. Magyar, A. Falus, et al. Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE Int. Immunol., August 1, 2003; 15(8): 963 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Sewell, E. K. Reinke, D. O. Co, L. H. Hogan, R. B. Fritz, M. Sandor, and Z. Fabry Infection with Mycobacterium bovis BCG Diverts Traffic of Myelin Oligodendroglial Glycoprotein Autoantigen-Specific T Cells Away from the Central Nervous System and Ameliorates Experimental Autoimmune Encephalomyelitis Clin. Vaccine Immunol., July 1, 2003; 10(4): 564 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Myles, R. S. Livingston, B. A. Livingston, J. M. Criley, and C. L. Franklin Analysis of Gene Expression in Ceca of Helicobacter hepaticus-Infected A/JCr Mice before and after Development of Typhlitis Infect. Immun., July 1, 2003; 71(7): 3885 - 3893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-C. Chiu, C. M. Freeman, V. R. Stolberg, E. Komuniecki, P. M. Lincoln, S. L. Kunkel, and S. W. Chensue Cytokine-Chemokine Networks in Experimental Mycobacterial and Schistosomal Pulmonary Granuloma Formation Am. J. Respir. Cell Mol. Biol., July 1, 2003; 29(1): 106 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. deSchoolmeester, M. C. Little, B. J. Rollins, and K. J. Else Absence of CC Chemokine Ligand 2 Results in an Altered Th1/Th2 Cytokine Balance and Failure to Expel Trichuris muris Infection J. Immunol., May 1, 2003; 170(9): 4693 - 4700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Scott and J. L. Flynn Mycobacterium tuberculosis in Chemokine Receptor 2-Deficient Mice: Influence of Dose on Disease Progression Infect. Immun., November 1, 2002; 70(11): 5946 - 5954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Chiu, X.-Z. Shang, V. R. Stolberg, E. Komuniecki, and S. W. Chensue Population analysis of CD4+ T cell chemokine receptor transcript expression during in vivo type-1 (mycobacterial) and type-2 (schistosomal) immune responses J. Leukoc. Biol., August 1, 2002; 72(2): 363 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Z. Shang, B.-C. Chiu, V. Stolberg, N. W. Lukacs, S. L. Kunkel, H. S. Murphy, and S. W. Chensue Eosinophil Recruitment in Type-2 Hypersensitivity Pulmonary Granulomas : Source and Contribution of Monocyte Chemotactic Protein-3 (CCL7) Am. J. Pathol., July 1, 2002; 161(1): 257 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Roach, A. G. D. Bean, C. Demangel, M. P. France, H. Briscoe, and W. J. Britton TNF Regulates Chemokine Induction Essential for Cell Recruitment, Granuloma Formation, and Clearance of Mycobacterial Infection J. Immunol., May 1, 2002; 168(9): 4620 - 4627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Endlich, D. Armstrong, J. Brodsky, M. Novotny, and T. A. Hamilton Distinct Temporal Patterns of Macrophage-Inflammatory Protein-2 and KC Chemokine Gene Expression in Surgical Injury J. Immunol., April 1, 2002; 168(7): 3586 - 3594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. F. Foxman, M. Zhang, S. D. Hurst, T. Muchamuel, D. Shen, E. F. Wawrousek, C.-C. Chan, and I. Gery Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation J. Immunol., March 1, 2002; 168(5): 2483 - 2492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. F. Power, T. Huss, V. Michaud, H. Plotnicky-Gilquin, J.-Y. Bonnefoy, and T. N. Nguyen Differential Histopathology and Chemokine Gene Expression in Lung Tissues following Respiratory Syncytial Virus (RSV) Challenge of Formalin-Inactivated RSV- or BBG2Na-Immunized Mice J. Virol., December 15, 2001; 75(24): 12421 - 12430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Park, K. F. Hoffmann, A. W. Cheever, D. Amichay, T. A. Wynn, and J. M. Farber Patterns of Chemokine Expression in Models of Schistosoma mansoni Inflammation and Infection Reveal Relationships between Type 1 and Type 2 Responses and Chemokines In Vivo Infect. Immun., November 1, 2001; 69(11): 6755 - 6768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Chensue Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions Clin. Microbiol. Rev., October 1, 2001; 14(4): 821 - 835. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
