This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Takeda, H. Articles by Kondo, S. Search for Related Content PubMed PubMed Citation Articles by Takeda, H. Articles by Kondo, S.

(American Journal of Pathology. 2001;158:1633-1637.)
© 2001 American Society for Investigative Pathology

Regular Articles

Differences between Squamous Cell Carcinoma and Keratoacanthoma in Angiotensin Type-1 Receptor Expression

From the Department of Dermatology, Yamagata University School of Medicine, Yamagata, Japan

Angiotensin II receptors are the specific receptors of angiotensin II of the renin-angiotensin system. The existence and role of the receptors in the skin have not been determined. We immunohistochemically studied the expression of angiotensin receptors in the human skin. The results demonstrated the expression of angiotensin type 1 receptor (AT1) in the normal human suprabasal epidermis. The expression pattern suggests the role of AT1 in association with differentiation. In addition, we studied the expression of AT1 in squamous cell carcinoma (SCC) of the skin, SCC of the lip, and keratoacanthoma (KA). Our experiments showed that high, intermediate, and low levels of AT1 were observed in 37 (74.0%), 7 (14.0%), and 2 (4.0%) of 50 cases of SCC of the skin, respectively, and the negative periphery pattern was observed in 17 (77.3%) of 22 cases of KA. These observations suggest that the immunohistochemical study of AT1 is useful to distinguish SCC from KA. Studying the role and distribution of AT1 may help in understanding the pathophysiology of the skin.

This article has been cited by other articles:

				M A Redondo-Muller, M Stevanovic-Walker, S Barker, J R Puddefoot, and G P Vinson Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor Endocr. Relat. Cancer, March 1, 2008; 15(1): 277 - 288. [Abstract] [Full Text] [PDF]

				T. Suganuma, K. Ino, K. Shibata, H. Kajiyama, T. Nagasaka, S. Mizutani, and F. Kikkawa Functional Expression of the Angiotensin II Type1 Receptor in Human Ovarian Carcinoma Cells and Its Blockade Therapy Resulting in Suppression of Tumor Invasion, Angiogenesis, and Peritoneal Dissemination Clin. Cancer Res., April 1, 2005; 11(7): 2686 - 2694. [Abstract] [Full Text] [PDF]

				W.-P. Koh, J.-M. Yuan, D. Van Den Berg, H.-P. Lee, and M. C. Yu Polymorphisms in angiotensin II type 1 receptor and angiotensin I-converting enzyme genes and breast cancer risk among Chinese women in Singapore Carcinogenesis, February 1, 2005; 26(2): 459 - 464. [Abstract] [Full Text] [PDF]

				A. Miyajima, T. Kosaka, T. Asano, T. Asano, K. Seta, T. Kawai, and M. Hayakawa Angiotensin II Type I Antagonist Prevents Pulmonary Metastasis of Murine Renal Cancer by Inhibiting Tumor Angiogenesis Cancer Res., August 1, 2002; 62(15): 4176 - 4179. [Abstract] [Full Text] [PDF]