help button home button Am J Pathol Epitomics, Inc.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moon, B.-K.
Right arrow Articles by Kim, H.-R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moon, B.-K.
Right arrow Articles by Kim, H.-R. C.
(American Journal of Pathology. 2001;159:1055-1060.)
© 2001 American Society for Investigative Pathology

Regular Articles

Galectin-3 Protects Human Breast Carcinoma Cells against Nitric Oxide-Induced Apoptosis

Implication of Galectin-3 Function during Metastasis

Bong-Ki Moon*§, Yong J. Lee{dagger}, Paul Battle{dagger}, J. Milburn Jessup{ddagger}, Avraham Raz§ and Hyeong-Reh Choi Kim§

From the Department of Anesthesiology,*
Ajou University School of Medicine, Suwon, Korea; the Department of Pharmacology,{dagger}
University of Pittsburgh, Pittsburgh, Pennsylvania; the Department of Surgery,{ddagger}
The University of Texas Health Science Center at San Antonio, San Antonio, Texas; and the Department of Pathology,§
Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan

Galectin-3 is a ß-galactoside-binding protein which regulates many biological processes including cell adhesion, migration, cell growth, tumor progression, metastasis, and apoptosis. Although the exact function of galectin-3 in cancer development is unclear, galectin-3 expression is associated with neoplastic progression and metastatic potential. Since studies have suggested that tumor cell survival in microcirculation determines the metastatic outcome, we examined the effect of galectin-3 overexpression in human breast carcinoma cell survival using the liver ischemia/reperfusion metastasis model. While the majority of control cells died by hepatic ischemia/reoxygenation, nearly all of galectin-3 overexpressing cells survived. We showed that galectin-3 inhibits nitrogen free radical-mediated apoptosis, one of the major death pathways induced during hepatic ischemia/reperfusion. Galectin-3 inhibition of apoptosis involved protection of mitochondrial integrity, inhibition of cytochrome c release and caspase activation. Taking these results together with the previous observation that galectin-3 inhibits apoptosis induced by loss of cell adhesion, we propose that galectin-3 is a critical determinant for anchorage-independent and free radical-resistant cell survival during metastasis.




This article has been cited by other articles:


Home page
 J EndocrinolHome page
L. V Norling, M. Perretti, and D. Cooper
Endogenous galectins and the control of the host inflammatory response
J. Endocrinol., May 1, 2009; 201(2): 169 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. Peng, H. Y. Wang, Y. Miyahara, G. Peng, and R.-F. Wang
Tumor-Associated Galectin-3 Modulates the Function of Tumor-Reactive T Cells
Cancer Res., September 1, 2008; 68(17): 7228 - 7236.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
T. Szoke, K. Kayser, I. Trojan, G. Kayser, J. Furak, L. Tiszlavicz, J.-D. Baumhakel, and H.-J. Gabius
The role of microvascularization and growth/adhesion-regulatory lectins in the prognosis of non-small cell lung cancer in stage II
Eur. J. Cardiothorac. Surg., May 1, 2007; 31(5): 783 - 787.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. G. Prieto, A. A. Mourad-Zeidan, V. Melnikova, M. M. Johnson, A. Lopez, A. H. Diwan, A. J.F. Lazar, S. S. Shen, P. S. Zhang, J. A. Reed, et al.
Galectin-3 Expression Is Associated with Tumor Progression and Pattern of Sun Exposure in Melanoma.
Clin. Cancer Res., November 15, 2006; 12(22): 6709 - 6715.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. N. Stillman, D. K. Hsu, M. Pang, C. F. Brewer, P. Johnson, F.-T. Liu, and L. G. Baum
Galectin-3 and Galectin-1 Bind Distinct Cell Surface Glycoprotein Receptors to Induce T Cell Death
J. Immunol., January 15, 2006; 176(2): 778 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Mazurek, Y. J. Sun, J. E. Price, L. Ramdas, W. Schober, P. Nangia-Makker, J. C. Byrd, A. Raz, and R. S. Bresalier
Phosphorylation of Galectin-3 Contributes to Malignant Transformation of Human Epithelial Cells via Modulation of Unique Sets of Genes
Cancer Res., December 1, 2005; 65(23): 10767 - 10775.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
G. C. Fernandez, J. M. Ilarregui, C. J. Rubel, M. A. Toscano, S. A. Gomez, M. Beigier Bompadre, M. A. Isturiz, G. A. Rabinovich, and M. S. Palermo
Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways
Glycobiology, May 1, 2005; 15(5): 519 - 527.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. B. Wreesmann, E. M. Sieczka, N. D. Socci, M. Hezel, T. J. Belbin, G. Childs, S. G. Patel, K. N. Patel, G. Tallini, M. Prystowsky, et al.
Genome-Wide Profiling of Papillary Thyroid Cancer Identifies MUC1 as an Independent Prognostic Marker
Cancer Res., June 1, 2004; 64(11): 3780 - 3789.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Takenaka, T. Fukumori, T. Yoshii, N. Oka, H. Inohara, H.-R. C. Kim, R. S. Bresalier, and A. Raz
Nuclear Export of Phosphorylated Galectin-3 Regulates Its Antiapoptotic Activity in Response to Chemotherapeutic Drugs
Mol. Cell. Biol., May 15, 2004; 24(10): 4395 - 4406.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. K. Hoyer, M. Pang, D. Gui, I. P. Shintaku, I. Kuwabara, F.-T. Liu, J. W. Said, L. G. Baum, and M. A. Teitell
An Anti-Apoptotic Role for Galectin-3 in Diffuse Large B-Cell Lymphomas
Am. J. Pathol., March 1, 2004; 164(3): 893 - 902.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. M. John, H. Leffler, B. Kahl-Knutsson, I. Svensson, and G. A. Jarvis
Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer
Clin. Cancer Res., June 1, 2003; 9(6): 2374 - 2383.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Qiu, F.W. Orr, D. Jensen, H. H. Wang, A. R. McIntosh, B. B. Hasinoff, D. M. Nance, S. Pylypas, K. Qi, C. Song, et al.
Arrest of B16 Melanoma Cells in the Mouse Pulmonary Microcirculation Induces Endothelial Nitric Oxide Synthase-Dependent Nitric Oxide Release that Is Cytotoxic to the Tumor Cells
Am. J. Pathol., February 1, 2003; 162(2): 403 - 412.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
J. D. Hernandez and L. G. Baum
Ah, sweet mystery of death! Galectins and control of cell fate
Glycobiology, October 1, 2002; 12(10): 127R - 136R.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. A. Rabinovich, N. Rubinstein, and L. Fainboim
Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology
J. Leukoc. Biol., May 1, 2002; 71(5): 741 - 752.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Yoshii, T. Fukumori, Y. Honjo, H. Inohara, H.-R. C. Kim, and A. Raz
Galectin-3 Phosphorylation Is Required for Its Anti-apoptotic Function and Cell Cycle Arrest
J. Biol. Chem., February 22, 2002; 277(9): 6852 - 6857.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. J. Lee and Y. K. Song
Cooperative Interaction between Interleukin 10 and Galectin-3 against Liver Ischemia-Reperfusion Injury
Clin. Cancer Res., January 1, 2002; 8(1): 217 - 220.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Society for Investigative Pathology.