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(American Journal of Pathology. 2001;159:803-808.)
© 2001 American Society for Investigative Pathology

Short Communications

Phospholipase C {delta}2 Expression Characterizes the Neoplastic Transformation of the Human Gastric Mucosa

Marco Marchisio*, Angela Di Baldassarre*, Domenico Angelucci{dagger}, Elisabetta Caramelli{ddagger}, Amelia Cataldi*, Sergio Castorina§, Adriano Antonucci*, Luigina Di Giovannantonio{dagger}, Cosima Schiavone, Rosa Di Biagio*, Mirella Falconi||, Giorgio Zauli* and Sebastiano Miscia*

From the Section of Human Anatomy at the Department of Biomorphology,*
the Section of Pathology at the Department of Oncology and Neuroscience,{dagger}
the Department of Medicine and Aging Sciences,
School of Medicine, University of Chieti, Chieti; the Institute of Histology and General Embryology,{ddagger}
University of Bologna, Bologna; the Institute of Human Anatomy,§
University of Catania, Catania; and the Institute of Cytomorphology,||
Consiglio Nazionale Delle Ricerche, Bologna, Italy

The expression, cellular distribution, and activity of PIP2-specific phospholipase C (PLC) in healthy human gastric-mucosa cells have been recently studied in our laboratories and a direct evidence for an almost exclusive expression of PLC ß isoforms, with the exception of PLC ß4, has been provided. These results addressed our attention to possible modification of PLC expression and activity during neoplastic transformation of the human gastric mucosa. In the present article we present results indicating that PLC {delta}2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma whereas traces of other PLC isoforms were sometime detected. Interestingly, we found that type I intestinal metaplasia was in the majority of the cases PLC {delta}2-negative, but when expressed, this type of metaplasia generally considered as benignant, always evolved toward neoplastic transformation. These results therefore readdress the question of surveillance of the patients with type I intestinal metaplasia and suggest that PLC {delta}2 expression might be a possible marker of gastric malignant transformation.




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[Abstract] [Full Text] [PDF]


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Copyright © 2001 by the American Society for Investigative Pathology.