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(American Journal of Pathology. 2001;159:1193-1197.)
© 2001 American Society for Investigative Pathology

Short Communications

Anaplastic and Atypical Meningiomas Express High Levels of Fas and Undergo Apoptosis in Response to Fas Ligation

Shira Weisberg*, Ely Ashkenazi{dagger}, Zvi Israel{dagger}, Moshe Attia{dagger}, Yigal Shoshan{dagger}, Felix Umansky{dagger} and Chaya Brodie*

From the Gonda (Goldschmied) Medical Diagnosis Research Center,*
Faculty of Life Science, Bar-Ilan University, Ramat Gan; and the Department of Neurosurgery,{dagger}
Hadassah Ein Karem, Jerusalem, Israel

In this study we characterized the expression of Fas and Fas ligand in different types of meningiomas and examined the effect of Fas ligation on the death of meningioma cells in culture. Using Western blot analysis, we found that extracts derived from anaplastic and atypical meningiomas expressed high levels of Fas, whereas benign meningiomas did not express detectable levels of this protein. All of the meningiomas examined expressed low levels of Fas ligand. Cultures of anaplastic meningiomas also expressed Fas and treatment of these cells with anti-Fas antibody induced cell death. The results of this study indicate that Fas is preferentially expressed in atypical and anaplastic meningiomas and suggest that it is involved in the increased apoptosis observed in these tumors.






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Copyright © 2001 by the American Society for Investigative Pathology.