help button home button Am J Pathol JNCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lloyd, R. V.
Right arrow Articles by Friedman, T. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lloyd, R. V.
Right arrow Articles by Friedman, T. B.
(American Journal of Pathology. 2001;159:1375-1382.)
© 2001 American Society for Investigative Pathology

Regular Articles

Myosin XVA Expression in the Pituitary and in Other Neuroendocrine Tissues and Tumors

Ricardo V. Lloyd*, Sergio Vidal{dagger}, Long Jin*, Shuya Zhang*, Kalman Kovacs{ddagger}, Eva Horvath{ddagger}, Bernd W. Scheithauer*, Erich T. A. Boger§, Robert A. Fridell§ and Thomas B. Friedman§

From the Mayo Clinic and Mayo Foundation,*
Rochester, Minnesota; the University of Santiago de Compostela,{dagger}
Lugo, Spain; the St. Michaels Hospital and University of Toronto,{ddagger}
Toronto, Ontario, Canada; and the Laboratory of Molecular Genetics,§
National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland

The myosin superfamily of molecular motor proteins includes conventional myosins and several classes of unconventional myosins. Recent studies have characterized the human and mouse unconventional myosin XVA, which has a role in the formation and/or maintenance of the unique actin-rich structures of inner ear sensory hair cells. Myosin XVA is also highly expressed in human anterior pituitary cells. In this study we examined the distribution of myosin XVA protein and mRNA in normal and neoplastic human pituitaries and other neuroendocrine cells and tumors. Myosin XVA was expressed in all types of normal anterior pituitary cells and pituitary tumors and in other neuroendocrine cells and tumors including those of the adrenal medulla, parathyroid, and pancreatic islets. Most nonneuroendocrine tissues examined including liver cells were negative for myosin XVA protein and mRNA, although the distal and proximal tubules of normal kidneys showed moderate immunoreactivity for myosin XVA. Ultrastructural immunohistochemistry localized myosin XVA in association with secretory granules of human anterior pituitary cells and human pituitary tumors. These data suggest that in neuroendocrine cells myosin XVA may have a role in secretory granule movement and/or secretion.




This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
S. La Rosa, S. Uccella, S. Marchet, C. Capella, and R. V. Lloyd
Localization of Inhibins and Activins in Normal Endocrine Cells and Endocrine Tumors of the Gut and Pancreas: an Immunohistochemical and In Situ Hybridization Study
J. Histochem. Cytochem., February 1, 2004; 52(2): 217 - 225.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
I. J. Karolyi, F. J. Probst, L. Beyer, H. Odeh, G. Dootz, K. B. Cha, D. M. Martin, K. B. Avraham, D. Kohrman, D. F. Dolan, et al.
Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia
Hum. Mol. Genet., November 1, 2003; 12(21): 2797 - 2805.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Society for Investigative Pathology.