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(American Journal of Pathology. 2001;159:1597-1602.)
© 2001 American Society for Investigative Pathology

Short Communication

Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer’s Disease and Stimulates Tau Phosphorylation

Qi Chen*, Hirotaka Yoshida*, David Schubert*, Pamela Maher{dagger}, Margaret Mallory{ddagger} and Eliezer Masliah{ddagger}

From the Cellular Neurobiology Laboratory,*
The Salk Institute for Biological Studies, La Jolla; the Department of Cell Biology,{dagger}
The Scripps Research Institute, La Jolla; and the Department of Neurosciences,{ddagger}
University of California, San Diego, La Jolla, California

A novel presenilin binding protein, PBP, has recently been identified. PBP is localized to the particulate fraction of extracts of Alzheimer’s disease brain but is found in the soluble fractions of brain from age matched normal controls. It is shown here that PBP is associated with neurofibrillary tangles in Alzheimer’s disease brain. In addition, the expression of PBP increases the phosphorylation of tau in cultured cells. Therefore PBP may have a regulatory role in tau phosphorylation and in the genesis of neurofibrillary tangles.




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Copyright © 2001 by the American Society for Investigative Pathology.