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(American Journal of Pathology. 2001;159:1941-1948.)
© 2001 American Society for Investigative Pathology

Regular Articles

Loss of Heterozygosity on Chromosomes 9q and 16p in Atypical Adenomatous Hyperplasia Concomitant with Adenocarcinoma of the Lung

Kazuya Takamochi^*, Tsutomu Ogura^*, Kenji Suzuki, Hidenori Kawasaki^*, Yukiko Kurashima^*, Tomoyuki Yokose, Atsushi Ochiai, Kanji Nagai, Yutaka Nishiwaki and Hiroyasu Esumi^*

From the Divsions of Investigative Treatment^*
and Pathology,
National Cancer Center Research Institute East, Chiba; the Division of Thoracic Oncology,
National Cancer Center Hospital East, Chiba; and the Division of Thoracic Surgery,
National Cancer Center Hospital, Tokyo, Japan

Atypical adenomatous hyperplasia (AAH) has recently been implicated as a precursor to lung adenocarcinoma. We previously reported loss of heterozygosity (LOH) in tuberous sclerosis (TSC) gene-associated regions to frequently be observed in lung adenocarcinoma with multiple AAHs. In this study, we analyzed LOH in four microsatellite loci on 9q, including the TSC1 gene-associated region, and four loci on 16p, including the TSC2 gene-associated region, in both 18 AAHs and 17 concomitant lung adenocarcinomas from 11 patients. Seven of 18 (39%) AAHs and 9 of 17 (53%) adenocarcinomas displayed LOH on 9q. Five (28%) AAHs and seven (41%) adenocarcinomas harbored LOH at loci adjacent to the TSC1 gene. Four of 18 (22%) AAHs and 6 of 17 (35%) adenocarcinomas displayed LOH on 16p. One (6%) AAH and five (29%) adenocarcinomas harbored LOH at loci adjacent to the TSC2 gene. These findings may indicate a causal relationship of LOH on 9q and 16p in a fraction of AAH lesions and adenocarcinomas of the lung. Especially, the frequencies of LOH on 9q and at the TSC1 gene-associated region were high. The TSC1 gene or another neighboring tumor suppressor gene on 9q might be involved in an early stage of the pathogenesis of lung adenocarcinoma.

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