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(American Journal of Pathology. 2002;160:1001-1008.)
© 2002 American Society for Investigative Pathology

Regular Articles

Lectin Histochemistry of Resected Adenocarcinoma of the Lung

Helix pomatia Agglutinin Binding Is an Independent Prognostic Factor

Eckart Laack*, Haleh Nikbakht*, Anja Peters{dagger}, Christian Kugler{ddagger}, Yvonne Jasiewicz§, Lutz Edler§, Dieter Kurt Hossfeld* and Udo Schumacher

From the Department of Oncology and Hematology*
and the Institute for Anatomy,
UniversityHospital Hamburg-Eppendorf, Hamburg; the Departments ofPathology{dagger}
andSurgery,{ddagger}
General Hospital Harburg, Harburg;and the German Cancer Research Center,§
Heidelberg, Germany

The worldwide incidence of adenocarcinoma of the lung is rising. Unfortunately, no significant prognostic marker beyond the classical TNM staging exists to stratify these patients for appropriate therapy. Because lectins, carbohydrate-binding proteins, have been shown to be useful prognostic markers in several other adenocarcinomas, a panel of lectins [Helix pomatia agglutinin (HPA), Phaseolus vulgaris leukoagglutinin, Ulex europaeus agglutinin, Maackia amurenis agglutinin, Sambucus nigra agglutinin] with different carbohydrate-binding specificities were tested for their prognostic relevance. Paraffin wax sections of 93 patients with adenocarcinomas of the lung who had undergone surgery between 1990 and 1995 were investigated by lectin histochemistry. Lectin-binding data and other known prognostic factors were correlated with survival. In univariate analysis, binding of HPA, Phaseolus vulgaris leukoagglutinin, and Ulex europaeus agglutinin to adenocarcinoma cells were prognostic indicators for overall and relapse-free survival, whereas Maackia amurenis agglutinin and Sambucus nigra agglutinin binding had no prognostic value. However, in a multivariate analysis next to stage and gender only HPA was a significant independent prognostic factor on survival. In conclusion, HPA binding was the primary marker-based predictor of prognosis in our patient population and allows to stratify patients with adenocarcinomas of the lung into a low- and a high-risk group.




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