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(American Journal of Pathology. 2002;161:13-17.)
© 2002 American Society for Investigative Pathology

Short Communication

Immunization Delays the Onset of Prion Disease in Mice

Einar M. Sigurdsson*{dagger}, David R. Brown{ddagger}, Maki Daniels{ddagger}, Richard J. Kascsak§, Regina Kascsak§, Richard Carp§, Harry C. Meeker§, Blas Frangione*{dagger} and Thomas Wisniewski*{dagger}

From the Departments of Psychiatry,*Pathology,{dagger}and Neurology,New York University School of Medicine, New York, New York; the New York State Institute for Basic Research in Developmental Disabilities,§Staten Island, New York; and the Departments of Biology and Biochemistry,{ddagger}University of Bath, Bath, United Kingdom

The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a potentially large population being at risk to develop this prionosis. None of the prionoses currently have an effective treatment. Recently, vaccination has been shown to be effective in mouse models of another neurodegenerative condition, namely Alzheimer’s disease. Here we report that vaccination with recombinant mouse prion protein delays the onset of prion disease in mice. Vaccination was performed both before peripheral prion exposure and after exposure. A delay in disease onset was seen in both groups, but was more prolonged in animals immunized before exposure. The increase in the incubation period closely correlated with the anti-prion protein antibody titer. This promising finding suggests that a similar approach may work in humans or other mammalian species at risk for prion disease.


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