This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Services Related articles in Am J Pathol Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mueller, W. Articles by von Deimling, A. Search for Related Content PubMed PubMed Citation Articles by Mueller, W. Articles by von Deimling, A.

(American Journal of Pathology. 2002;161:313-319.)
© 2002 American Society for Investigative Pathology

Regular Articles

Genetic Signature of Oligoastrocytomas Correlates with Tumor Location and Denotes Distinct Molecular Subsets

Wolf Mueller^*, Christian Hartmann^*, Annegret Hoffmann^*, Wolfgang Lanksch, Jürgen Kiwit, Jörg Tonn^¶, Julian Veelken^||, Johannes Schramm^**, Michael Weller, Otmar D. Wiestler, David N. Louis and Andreas von Deimling^*

From the Departments of Neuropathology^*and Neurosurgery,Charité, Humboldt University, Berlin, Germany; the Department of Neurosurgery,Helios Kliniken GmbH, Buch, Germany; the Department of Neurosurgery,^¶Ludwig Maximilian University, Munich, Germany; the Department of Neurosurgery,^||Vivantes Klinikum Neukölln, Berlin, Germany; the Department of Neurosurgery,^**University of Bonn Medical Center, Bonn, Germany; the Department of Neurology,Eberhard-Karls-Universität, Tübingen, Germany; the Department of Neuropathology,University of Bonn Medical Center, Bonn, Germany; and the Molecular Neuro-Oncology and Pathology Laboratories,Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

Oligoastrocytomas are heterogeneous tumors that have molecular features that overlap with either oligodendrogliomas or astrocytomas. Differences in the frequency of chromosomal losses of 1p and 19q in oligodendrogliomas are related to tumor location, with a low rate of allelic loss in tumors of the temporal and a high rate in tumors of the frontal, parietal, and occipital lobes. To test the possibility of regional molecular heterogeneity in oligoastrocytoma, we examined a series of 203 gliomas including 68 oligoastrocytomas and two control groups of 73 oligodendrogliomas and 62 astrocytomas for allelic losses of chromosomal arms 1p and 19q, and TP53 mutations, and compared these data with tumor localization. Common molecular alterations were found in oligodendrogliomas and oligoastrocytomas arising in extratemporal sites. In respect to the molecular parameters analyzed, temporal oligoastrocytomas were either indistinguishable from astrocytoma or similar to temporal oligodendrogliomas. Oligodendroglial neoplasms can thus be separated into three molecular subsets, two of which include lesions with the morphological features of oligodendrogliomas and oligoastrocytomas and one resembling temporal oligoastrocytoma. Molecular subclassification thus unifies previous findings about prognosis, behavior, response to therapy, genotype, and location in oligodendroglial tumors.

Related articles in Am J Pathol:

This Month in AJP

Am J Pathol 2002 161: 1-2. [Full Text]  

This article has been cited by other articles:

				D. Schiff, P. D. Brown, and C. Giannini Outcome in adult low-grade glioma: The impact of prognostic factors and treatment Neurology, September 25, 2007; 69(13): 1366 - 1373. [Abstract] [Full Text] [PDF]

				S. Larjavaara, R. Mantyla, T. Salminen, H. Haapasalo, J. Raitanen, J. Jaaskelainen, and A. Auvinen Incidence of gliomas by anatomic location Neuro-oncol, July 1, 2007; 9(3): 319 - 325. [Abstract] [Full Text] [PDF]

				C. Hong, K. S. Moorefield, P. Jun, K. D. Aldape, S. Kharbanda, H. S. Phillips, and J. F. Costello Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth PNAS, June 26, 2007; 104(26): 10974 - 10979. [Abstract] [Full Text] [PDF]

				C. Walker, B. Haylock, D. Husband, K. A. Joyce, D. Fildes, M. D. Jenkinson, T. Smith, J. Broome, D. G. du Plessis, and P. C. Warnke Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors Neurology, June 13, 2006; 66(11): 1661 - 1667. [Abstract] [Full Text] [PDF]

				F. Laigle-Donadey, N. Martin-Duverneuil, J. Lejeune, E. Criniere, L. Capelle, H. Duffau, P. Cornu, P. Broet, M. Kujas, K. Mokhtari, et al. Correlations between molecular profile and radiologic pattern in oligodendroglial tumors Neurology, December 28, 2004; 63(12): 2360 - 2362. [Abstract] [Full Text] [PDF]

				J. G. Cairncross Imaging Molecular Signatures in Oligodendroglioma: Commentary on Walker et al., pages 7182-7191 Clin. Cancer Res., November 1, 2004; 10(21): 7109 - 7111. [Full Text] [PDF]

				C. Walker, D. G. du Plessis, D. Fildes, B. Haylock, D. Husband, M. D. Jenkinson, K. A. Joyce, J. Broome, K. Kopitski, J. Prosser, et al. Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component Clin. Cancer Res., November 1, 2004; 10(21): 7182 - 7191. [Abstract] [Full Text] [PDF]

				C. Walker, D. G. du Plessis, K. A. Joyce, Y. Machell, J. Thomson-Hehir, S. A. Al Haddad, J. C. Broome, and P. C. Warnke Phenotype versus Genotype in Gliomas Displaying Inter- or Intratumoral Histological Heterogeneity Clin. Cancer Res., October 15, 2003; 9(13): 4841 - 4851. [Abstract] [Full Text] [PDF]

				J. van den Boom, M. Wolter, R. Kuick, D. E. Misek, A. S. Youkilis, D. S. Wechsler, C. Sommer, G. Reifenberger, and S. M. Hanash Characterization of Gene Expression Profiles Associated with Glioma Progression Using Oligonucleotide-Based Microarray Analysis and Real-Time Reverse Transcription-Polymerase Chain Reaction Am. J. Pathol., September 1, 2003; 163(3): 1033 - 1043. [Abstract] [Full Text] [PDF]

				A. Perry Pathology of low-grade gliomas: An update of emerging concepts Neuro-oncol, July 1, 2003; 5(3): 168 - 178. [Abstract] [PDF]