| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Departments of Otolaryngology/Head and Neck Surgery* and Pathology, VU University Medical Center, Amsterdam, The Netherlands
The development of second primary tumors has a negative impact on the prognosis of head and neck squamous cell carcinoma. Previously, we detected genetically altered and tumor-related mucosal lesions in the resection margins in 25% of unselected head and neck squamous cell carcinoma patients (Tabor MP, Brakenhoff RH, van Houten VMM, Kummer JA, Snel MHJ, Snijders PJF, Snow GB, Leemans CR, Braakhuis BJM: Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res 2001, 7: 1523–1532). The aim of this study was to determine whether first and second primary tumors are clonally related and originate from a single genetically altered field. From 10 patients we analyzed the first tumor of the oral cavity or oropharynx, the >3-cm remote second primary tumor, and the mucosa from the tumor-free margins from both resection specimens. We compared TP53 mutations and loss of heterozygosity profiles using 19 microsatellite markers at chromosomes 3p, 9p, 13q, and 17p. In all patients, genetically altered mucosal lesions were detected in at least one resection margin from both first and second primary tumor. Evidence for a common clonal origin of the first tumor, second primary tumor, and the intervening mucosa was found for at least 6 of 10 patients. Our results indicate that a proportion of multiple primary tumors have developed within a single preneoplastic field. Based on different etiology and clinical consequences, we propose that independent second primary tumors should be distinguished from second field tumors, that arise from the same genetically altered field the first tumor has developed from.
This article has been cited by other articles:
 |
|
 |
|
  T. B.M. Schaaij-Visser, A. P. Graveland, S. Gauci, B. J.M. Braakhuis, M. Buijze, A. J.R. Heck, D. J. Kuik, E. Bloemena, C. R. Leemans, M. Slijper, et al. Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas Clin. Cancer Res., December 15, 2009; 15(24): 7666 - 7675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rhiner and E. Moreno Super competition as a possible mechanism to pioneer precancerous fields Carcinogenesis, May 1, 2009; 30(5): 723 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Poh, C. E. MacAulay, L. Zhang, and M. P. Rosin Tracing the "At-Risk" Oral Mucosa Field with Autofluorescence: Steps Toward Clinical Impact Cancer Prevention Research, May 1, 2009; 2(5): 401 - 404. [Full Text] [PDF]
|
|
|
|
|
|
J. F. Bremmer, A. P. Graveland, A. Brink, B. J.M. Braakhuis, D. J. Kuik, C. R. Leemans, E. Bloemena, I. van der Waal, and R. H. Brakenhoff Screening for Oral Precancer with Noninvasive Genetic Cytology Cancer Prevention Research, February 1, 2009; 2(2): 128 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chai and R. E. Brown Field Effect in Cancer-An Update Ann. Clin. Lab. Sci., January 1, 2009; 39(4): 331 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Choi and J.N. Myers Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy Journal of Dental Research, January 1, 2008; 87(1): 14 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Bian, T. J. Knobloch, M. Sadim, V. Kaklamani, A. Raji, G.-Y. Yang, C. M. Weghorst, and B. Pasche Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development Hum. Mol. Genet., December 15, 2007; 16(24): 3128 - 3135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Huang, S. Pateromichelakis, A. Hills, M. Sherriff, A. Lyons, J. Langdon, E. Odell, P. Morgan, J. Harrison, and M. Partridge p53 Mutations in Deep Tissues Are More Strongly Associated with Recurrence than Mutation-Positive Mucosal Margins Clin. Cancer Res., October 15, 2007; 13(20): 6099 - 6106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Lippman and J. V. Heymach The Convergent Development of Molecular-Targeted Drugs for Cancer Treatment and Prevention Clin. Cancer Res., July 15, 2007; 13(14): 4035 - 4041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Hayat, N. Howlader, M. E. Reichman, and B. K. Edwards Cancer Statistics, Trends, and Multiple Primary Cancer Analyses from the Surveillance, Epidemiology, and End Results (SEER) Program Oncologist, January 1, 2007; 12(1): 20 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wu, J. Gu, Q. Dong, M. Huang, K.-A. Do, W. K. Hong, and M. R. Spitz Joint Effect of Mutagen Sensitivity and Insulin-Like Growth Factors in Predicting the Risk of Developing Secondary Primary Tumors and Tumor Recurrence in Patients with Head and Neck Cancer Clin. Cancer Res., December 1, 2006; 12(23): 7194 - 7201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Westra and D. Sidransky Fluorescence Visualization in Oral Neoplasia: Shedding Light on an Old Problem. Clin. Cancer Res., November 15, 2006; 12(22): 6594 - 6597. [Full Text] [PDF]
|
|
|
|
 |
|
 B Perez-Ordonez, M Beauchemin, and R C K Jordan Molecular biology of squamous cell carcinoma of the head and neck. J. Clin. Pathol., May 1, 2006; 59(5): 445 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Celetti, D. Testa, S. Staibano, F. Merolla, V. Guarino, M. D. Castellone, R. Iovine, G. Mansueto, P. Somma, G. De Rosa, et al. Overexpression of the Cytokine Osteopontin Identifies Aggressive Laryngeal Squamous Cell Carcinomas and Enhances Carcinoma Cell Proliferation and Invasiveness Clin. Cancer Res., November 15, 2005; 11(22): 8019 - 8027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L L Loro, A C Johannessen, and O K Vintermyr Loss of BCL-2 in the progression of oral cancer is not attributable to mutations J. Clin. Pathol., November 1, 2005; 58(11): 1157 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J.M. Braakhuis, R. H. Brakenhoff, and C. R. Leemans Second Field Tumors: A New Opportunity for Cancer Prevention? Oncologist, August 1, 2005; 10(7): 493 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Kim and W. K. Hong An Apple a Day...Does It Really Keep the Doctor Away? The Current State of Cancer Chemoprevention J Natl Cancer Inst, April 6, 2005; 97(7): 468 - 470. [Full Text] [PDF]
|
|
|
|
|
|
B. J. M. Braakhuis, P. J. F. Snijders, W.-J. H. Keune, C. J. L. M. Meijer, H. J. Ruijter-Schippers, C. R. Leemans, and R. H. Brakenhoff Genetic Patterns in Head and Neck Cancers That Contain or Lack Transcriptionally Active Human Papillomavirus J Natl Cancer Inst, July 7, 2004; 96(13): 998 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Tabor, R. H. Brakenhoff, H. J. Ruijter-Schippers, J. A. Kummer, C. R. Leemans, and B. J. M. Braakhuis Genetically Altered Fields as Origin of Locally Recurrent Head and Neck Cancer: A Retrospective Study Clin. Cancer Res., June 1, 2004; 10(11): 3607 - 3613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Tsao, E. S. Kim, and W. K. Hong Chemoprevention of Cancer CA Cancer J Clin, May 1, 2004; 54(3): 150 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. M. Braakhuis, C. R. Leemans, R. H. Brakenhoff, M. P. Rosin, W. L. Lam, and L. Zhang Correspondence re: M. P. Rosin et al., 3p14 and 9p21 Loss Is a Simple Tool for Predicting Second Oral Malignancy at Previously Treated Oral Cancer Sites. Cancer Res., 62: 6447-6450, 2002. Cancer Res., August 15, 2003; 63(16): 5167 - 5169. [Full Text] [PDF]
|
|
|
|
|
|
B. J. M. Braakhuis, M. P. Tabor, J. A. Kummer, C. R. Leemans, and R. H. Brakenhoff A Genetic Explanation of Slaughter's Concept of Field Cancerization: Evidence and Clinical Implications Cancer Res., April 15, 2003; 63(8): 1727 - 1730. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
