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(American Journal of Pathology. 2002;161:755-761.)
© 2002 American Society for Investigative Pathology

Short Communication

The Role of the Thymus in Development of Necrotizing Arteritis in Transgenic Rats Carrying the env-pX Gene of Human T-Cell Leukemia Virus Type-I

Kazunori Fugo, Akihiro Ishizu, Hitoshi Ikeda, Hiroko Hayase, Toshiaki Sugaya, Masato Higuchi, Muneharu Tsuji, Asami Abe, Akira Suzuki, Masahiko Shibata, Toshiyuki Takahashi and Takashi Yoshiki

From the Department of Pathology/Pathophysiology, Division of Pathophysiological Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Necrotizing arteritis mimicking polyarteritis nodosa occurred in transgenic rats carrying the env-pX gene of human T-cell leukemia virus type I. To investigate the pathogenesis of necrotizing arteritis in these rats (env-pX rats), adoptive transfers of spleen cells and bone marrow cells were done from env-pX rats before they developed arteritis to nontransgenic rats. Necrotizing arteritis occurred in lethally irradiated nontransgenic rats reconstituted by env-pX spleen cells, thus indicating that the env-pX transgene in affected vessels may not be essential for the development of arteritis. In contrast, arteritis was not induced in nontransgenic recipients by adoptive transfers of env-pX bone marrow cells, which suggested that T cells derived from the env-pX thymus may play a role in the development of arteritis. To clarify if the process of differentiation of T cells in the env-pX thymus is crucial to develop necrotizing arteritis, reciprocal exchange of thymus frameworks was done between env-pX and nontransgenic rats. Necrotizing arteritis occurred in nontransgenic rats with an env-pX thymus framework, whereas development of arteritis was suppressed in env-pX rats in which the thymus framework was replaced with a nontransgenic one. This collective evidence shows that the thymus is directly associated with the development of necrotizing arteritis in env-pX rats.




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H. Hayase, A. Ishizu, H. Ikeda, Y. Miyatake, T. Baba, M. Higuchi, A. Abe, U. Tomaru, and T. Yoshiki
Aberrant gene expression by CD25+CD4+ immunoregulatory T cells in autoimmune-prone rats carrying the human T cell leukemia virus type-I gene
Int. Immunol., June 1, 2005; 17(6): 677 - 684.
[Abstract] [Full Text] [PDF]


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Copyright © 2002 by the American Society for Investigative Pathology.