help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kronqvist, P.
Right arrow Articles by Wewer, U. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kronqvist, P.
Right arrow Articles by Wewer, U. M.
(American Journal of Pathology. 2002;161:1535-1540.)
© 2002 American Society for Investigative Pathology

Short Communication

ADAM12 Alleviates the Skeletal Muscle Pathology in mdx Dystrophic Mice

Pauliina Kronqvist*, Nobuko Kawaguchi*, Reidar Albrechtsen*, Xiufeng Xu*, Henrik Daa Schrøder{dagger}, Behzad Moghadaszadeh*, Finn Cilius Nielsen{ddagger}, Camilla Fröhlich*, Eva Engvall§ and Ulla M. Wewer*

From the Institute of Molecular Pathology,* University of Copenhagen, Copenhagen, Denmark; the Department of Clinical Biochemistry,{ddagger} Copenhagen University Hospital, Copenhagen, Denmark; the Department of Pathology,{dagger} Odense University, Odense, Denmark; and The Burnham Institute,§ La Jolla, California

Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. In this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Liu, D. J. Burkin, and S. J. Kaufman
Increasing {alpha}7{beta}1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression
Am J Physiol Cell Physiol, February 1, 2008; 294(2): C627 - C640.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. H. Jorgensen, C. H. Jensen, U. M. Wewer, and H. D. Schroder
Transgenic Overexpression of ADAM12 Suppresses Muscle Regeneration and Aggravates Dystrophy in Aged mdx Mice
Am. J. Pathol., November 1, 2007; 171(5): 1599 - 1607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Xu, K. Chandrasekharan, J. H. Yoon, M. Camboni, and P. T. Martin
Overexpression of the Cytotoxic T Cell (CT) Carbohydrate Inhibits Muscular Dystrophy in the dyW Mouse Model of Congenital Muscular Dystrophy 1A
Am. J. Pathol., July 1, 2007; 171(1): 181 - 199.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. Dogra, H. Changotra, N. Wedhas, X. Qin, J. E. Wergedal, and A. Kumar
TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine
FASEB J, June 1, 2007; 21(8): 1857 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. M. Manso, L. Elsherif, S.-M. Kang, and R. S. Ross
Integrins, membrane-type matrix metalloproteinases and ADAMs: Potential implications for cardiac remodeling
Cardiovasc Res, February 15, 2006; 69(3): 574 - 584.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
J. Laigaard, T. Sorensen, S. Placing, P. Holck, C. Frohlich, K. R. Wojdemann, K. Sundberg, A.-C. Shalmi, A. Tabor, B. Norgaard-Pedersen, et al.
Reduction of the Disintegrin and Metalloprotease ADAM12 in Preeclampsia
Obstet. Gynecol., July 1, 2005; 106(1): 144 - 149.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Yi, J. Gruszczynska-Biegala, D. Wood, Z. Zhao, and A. Zolkiewska
Cooperation of the Metalloprotease, Disintegrin, and Cysteine-rich Domains of ADAM12 during Inhibition of Myogenic Differentiation
J. Biol. Chem., June 24, 2005; 280(25): 23475 - 23483.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Masaki, T. Kurisaki, K. Shirakawa, and A. Sehara-Fujisawa
Role of Meltrin {alpha} (ADAM12) in Obesity Induced by High- Fat Diet
Endocrinology, April 1, 2005; 146(4): 1752 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
P. Lafuste, C. Sonnet, B. Chazaud, P. A. Dreyfus, R. K. Gherardi, U. M. Wewer, and F.-J. Authier
ADAM12 and {alpha}9{beta}1 Integrin Are Instrumental in Human Myogenic Cell Differentiation
Mol. Biol. Cell, February 1, 2005; 16(2): 861 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. J. Burkin, G. Q. Wallace, D. J. Milner, E. J. Chaney, J. A. Mulligan, and S. J. Kaufman
Transgenic Expression of {alpha}7{beta}1 Integrin Maintains Muscle Integrity, Increases Regenerative Capacity, Promotes Hypertrophy, and Reduces Cardiomyopathy in Dystrophic Mice
Am. J. Pathol., January 1, 2005; 166(1): 253 - 263.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Sundberg, C. K. Thodeti, M. Kveiborg, C. Larsson, P. Parker, R. Albrechtsen, and U. M. Wewer
Regulation of ADAM12 Cell-surface Expression by Protein Kinase C {epsilon}
J. Biol. Chem., December 3, 2004; 279(49): 51601 - 51611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Hoyte, V. Jayasinha, B. Xia, and P. T. Martin
Transgenic Overexpression of Dystroglycan Does Not Inhibit Muscular Dystrophy in mdx Mice
Am. J. Pathol., February 1, 2004; 164(2): 711 - 718.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Cao, Z. Zhao, J. Gruszczynska-Biegala, and A. Zolkiewska
Role of Metalloprotease Disintegrin ADAM12 in Determination of Quiescent Reserve Cells during Myogenic Differentiation In Vitro
Mol. Cell. Biol., October 1, 2003; 23(19): 6725 - 6738.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. Moghadaszadeh, R. Albrechtsen, L. T. Guo, M. Zaik, N. Kawaguchi, R. H. Borup, P. Kronqvist, H. D. Schroder, K. E. Davies, T. Voit, et al.
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased {alpha}7 integrin, utrophin and associated glycoproteins
Hum. Mol. Genet., October 1, 2003; 12(19): 2467 - 2479.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. Kawaguchi, C. Sundberg, M. Kveiborg, B. Moghadaszadeh, M. Asmar, N. Dietrich, C. K. Thodeti, F. C. Nielsen, P. Moller, A. M. Mercurio, et al.
ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating {beta}1 integrin function
J. Cell Sci., October 1, 2003; 116(19): 3893 - 3904.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
E. ENGVALL and U. M. WEWER
The new frontier in muscular dystrophy research: booster genes
FASEB J, September 1, 2003; 17(12): 1579 - 1584.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Horiuchi, G. Weskamp, L. Lum, H.-P. Hammes, H. Cai, T. A. Brodie, T. Ludwig, R. Chiusaroli, R. Baron, K. T. Preissner, et al.
Potential Role for ADAM15 in Pathological Neovascularization in Mice
Mol. Cell. Biol., August 15, 2003; 23(16): 5614 - 5624.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Society for Investigative Pathology.