| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
From the Departments of Pathology (Neuropathology),*Neurology,and Neuroscience,Albert Einstein College of Medicine, Bronx, New York; and the Section of Molecular Genetics and Microbiology,University of Texas at Austin, Austin, Texas
Chemokines are low molecular weight cytokines which act as chemoattractants for infiltrating cells bearing appropriate receptors (CCR) to sites of inflammation. It has been proposed that CCR2 on monocytes is responsible for their recruitment into the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, and two previous reports have described resistance of CCR2-/- mice to EAE. The present study examined three different mouse strains with CCR2 deletions for susceptibility to EAE. Animals were studied up to 4 months post-sensitization and were examined by neuropathology, RNase protection assay, in situ hybridization, and in vitro assays. All three strains were found to be susceptible to EAE: C57BL/6 x J129 and Balb c strains, 100%; and C57BL/6, 67%. Unusual in CNS lesions of CCR2-/- mice was an overabundance of neutrophils versus monocytes in wild-type animals. An attempt of the immune system to develop compensatory mechanisms for the lack of CCR2 was evidenced by a corresponding increase in mRNA for other chemokines and CCR. Inasmuch as neutrophils replaced monocytes and led to demyelination, our findings support the concept that promiscuity of chemokines and CCR was able to surmount the deletion of CCR2, still resulting in full expression of this autoimmune disease.
This article has been cited by other articles:
 |
|
 |
|
  R. A. Linker, N. Kruse, S. Israel, T. Wei, S. Seubert, A. Hombach, B. Holtmann, F. Luhder, R. M. Ransohoff, M. Sendtner, et al. Leukemia Inhibitory Factor Deficiency Modulates the Immune Response and Limits Autoimmune Demyelination: A New Role for Neurotrophic Cytokines in Neuroinflammation J. Immunol., February 15, 2008; 180(4): 2204 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhu, Y. Bando, S. Xiao, K. Yang, A. C. Anderson, V. K. Kuchroo, and S. J. Khoury CD11b+Ly-6Chi Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis J. Immunol., October 15, 2007; 179(8): 5228 - 5237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schori, R. Shechter, I. Shachar, and M. Schwartz Genetic Manipulation of CD74 in Mouse Strains of Different Backgrounds Can Result in Opposite Responses to Central Nervous System Injury J. Immunol., January 1, 2007; 178(1): 163 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Furtado, B. Pina, F. Tacke, S. Gaupp, N. van Rooijen, T. M. Moran, G. J. Randolph, R. M. Ransohoff, S. W. Chensue, C. S. Raine, et al. A Novel Model of Demyelinating Encephalomyelitis Induced by Monocytes and Dendritic Cells J. Immunol., November 15, 2006; 177(10): 6871 - 6879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mahad, M. K. Callahan, K. A. Williams, E. E. Ubogu, P. Kivisakk, B. Tucky, G. Kidd, G. A. Kingsbury, A. Chang, R. J. Fox, et al. Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis Brain, January 1, 2006; 129(1): 212 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. P. de Lema, H. Maier, T. J. Franz, M. Escribese, S. Chilla, S. Segerer, N. Camarasa, H. Schmid, B. Banas, S. Kalaydjiev, et al. Chemokine Receptor Ccr2 Deficiency Reduces Renal Disease and Prolongs Survival in MRL/lpr Lupus-Prone Mice J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3592 - 3601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. GODESSART Chemokine Receptors: Attractive Targets for Drug Discovery Ann. N.Y. Acad. Sci., June 1, 2005; 1051(1): 647 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Polanczyk, R. E. Jones, S. Subramanian, M. Afentoulis, C. Rich, M. Zakroczymski, P. Cooke, A. A. Vandenbark, and H. Offner T Lymphocytes Do Not Directly Mediate the Protective Effect of Estrogen on Experimental Autoimmune Encephalomyelitis Am. J. Pathol., December 1, 2004; 165(6): 2069 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Abromson-Leeman, R. Bronson, Y. Luo, M. Berman, R. Leeman, J. Leeman, and M. Dorf T-Cell Properties Determine Disease Site, Clinical Presentation, and Cellular Pathology of Experimental Autoimmune Encephalomyelitis Am. J. Pathol., November 1, 2004; 165(5): 1519 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Ferrari, A. M. Depino, F. Prada, N. Muraro, S. Campbell, O. Podhajcer, V. H. Perry, D. C. Anthony, and F. J. Pitossi Reversible Demyelination, Blood-Brain Barrier Breakdown, and Pronounced Neutrophil Recruitment Induced by Chronic IL-1 Expression in the Brain Am. J. Pathol., November 1, 2004; 165(5): 1827 - 1837. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
