help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sanchez-Carbayo, M.
Right arrow Articles by Cordon-Cardo, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sanchez-Carbayo, M.
Right arrow Articles by Cordon-Cardo, C.
(American Journal of Pathology. 2003;162:609-617.)
© 2003 American Society for Investigative Pathology

Regular Articles

Tumor Suppressor Role of KiSS-1 in Bladder Cancer

Loss of KiSS-1 Expression Is Associated with Bladder Cancer Progression and Clinical Outcome

Marta Sanchez-Carbayo, Paola Capodieci and Carlos Cordon-Cardo

From the Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York

The expression profiles of nine bladder cancer cell lines were compared against a pool containing equal total RNA quantities of each of them. Lower expression of KiSS-1 was revealed in cells derived from the most advanced bladder tumors. When comparing 15 primary bladder tumors versus a pool of four bladder cancer cell lines, lower transcript levels of KiSS-1 were observed in the invasive bladder carcinomas as compared to superficial tumors. KiSS-1 expression ratios provided prognostic information. The expression pattern of KiSS-1 transcripts was analyzed using in situ hybridization in nine bladder cancer cells, paired normal urothelium and bladder tumor samples (n = 25), and tissue microarrays of bladder tumors (n = 173). We observed complete loss of KiSS-1 in all invasive tumors under study as compared to their respective normal urothelium. The expression of KiSS-1 was found to be significantly associated with histopathological stage. Patients with lower KiSS-1 expression showed a direct correlation with overall survival in a subset of bladder tumors whose follow-up was available (n = 69). We did not observe any significant differential KiSS-1 expression along cell cycle by sorting analysis. A potential tumor suppressor role in bladder cancer was revealed for KiSS-1. Moreover, it showed predictive value by identifying patients with poor outcome.




This article has been cited by other articles:


Home page
 J EndocrinolHome page
R A Silvestre, E M Egido, R Hernandez, and J Marco
Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas
J. Endocrinol., February 1, 2008; 196(2): 283 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
D. Marot, I. Bieche, C. Aumas, S. Esselin, C. Bouquet, S. Vacher, G. Lazennec, M. Perricaudet, F. Kuttenn, R. Lidereau, et al.
High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors
Endocr. Relat. Cancer, September 1, 2007; 14(3): 691 - 702.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. d'Anglemont de Tassigny, L. A. Fagg, J. P. C. Dixon, K. Day, H. G. Leitch, A. G. Hendrick, D. Zahn, I. Franceschini, A. Caraty, M. B. L. Carlton, et al.
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene
PNAS, June 19, 2007; 104(25): 10714 - 10719.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. Dissanayake, M. Wade, C. E. Johnson, M. P. O'Connell, P. D. Leotlela, A. D. French, K. V. Shah, K. J. Hewitt, D. T. Rosenthal, F. E. Indig, et al.
The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition
J. Biol. Chem., June 8, 2007; 282(23): 17259 - 17271.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
G Nicolle, E Comperat, N Nicolaiew, G Cancel-Tassin, and O Cussenot
Metastin (KISS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder
Ann. Onc., March 1, 2007; 18(3): 605 - 607.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. S. Dhillo, P. Savage, K. G. Murphy, O. B. Chaudhri, M. Patterson, G. M. Nijher, V. M. Foggo, G. S. Dancey, H. Mitchell, M. J. Seckl, et al.
Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E878 - E884.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. M. Castellano, M. Gaytan, J. Roa, E. Vigo, V. M. Navarro, C. Bellido, C. Dieguez, E. Aguilar, J. E. Sanchez-Criado, A. Pellicer, et al.
Expression of KiSS-1 in Rat Ovary: Putative Local Regulator of Ovulation?
Endocrinology, October 1, 2006; 147(10): 4852 - 4862.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
M. Tena-Sempere
GPR54 and kisspeptin in reproduction
Hum. Reprod. Update, September 1, 2006; 12(5): 631 - 639.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. C. Mitchell, M. Abdelrahim, J. Weng, L. J. Stafford, S. Safe, M. Bar-Eli, and M. Liu
Regulation of KiSS-1 Metastasis Suppressor Gene Expression in Breast Cancer Cells by Direct Interaction of Transcription Factors Activator Protein-2{alpha} and Specificity Protein-1
J. Biol. Chem., January 6, 2006; 281(1): 51 - 58.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Stathatos, I. Bourdeau, A. V. Espinosa, M. Saji, V. V. Vasko, K. D. Burman, C. A. Stratakis, and M. D. Ringel
KiSS-1/G Protein-Coupled Receptor 54 Metastasis Suppressor Pathway Increases Myocyte-Enriched Calcineurin Interacting Protein 1 Expression and Chronically Inhibits Calcineurin Activity
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5432 - 5440.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. M. Navarro, J. M. Castellano, R. Fernandez-Fernandez, S. Tovar, J. Roa, A. Mayen, R. Nogueiras, M. J. Vazquez, M. L. Barreiro, P. Magni, et al.
Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54
Endocrinology, January 1, 2005; 146(1): 156 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
O. Modlich, H.-B. Prisack, G. Pitschke, U. Ramp, R. Ackermann, H. Bojar, T. A. Vogeli, and M.-O. Grimm
Identifying Superficial, Muscle-Invasive, and Metastasizing Transitional Cell Carcinoma of the Bladder: Use of cDNA Array Analysis of Gene Expression Profiles
Clin. Cancer Res., May 15, 2004; 10(10): 3410 - 3421.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Bilban, N. Ghaffari-Tabrizi, E. Hintermann, S. Bauer, S. Molzer, C. Zoratti, R. Malli, A. Sharabi, U. Hiden, W. Graier, et al.
Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts
J. Cell Sci., March 15, 2004; 117(8): 1319 - 1328.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Ikeguchi, K.-i. Yamaguchi, and N. Kaibara
Clinical Significance of the Loss of KiSS-1 and Orphan G-Protein-Coupled Receptor (hOT7T175) Gene Expression in Esophageal Squamous Cell Carcinoma
Clin. Cancer Res., February 15, 2004; 10(4): 1379 - 1383.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the American Society for Investigative Pathology.