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(American Journal of Pathology. 2003;162:1985-1993.)
© 2003 American Society for Investigative Pathology

Nitric Oxide Synthase 3-Dependent Vascular Remodeling and Circulatory Dysfunction in Cirrhosis

Guillermo Fernández-Varo*, Josefa Ros*, Manuel Morales-Ruiz*, Pilar Cejudo-Martín*, Vicente Arroyo{dagger}, Manel Solé{ddagger}, Francisca Rivera*, Juan Rodés{dagger} and Wladimiro Jiménez*

From the Hormonal Laboratory,* Liver Unit,{dagger} and Pathology Department,{ddagger} Hospital Clínic Universitari, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona and Instituto Reina Sofia de Investigaciones Nefrológicas, Barcelona, Spain

Vascular remodeling is an active process that consists in important modifications in the vessel wall. Endothelium-derived nitric oxide (NO) plays a major role in this phenomenon. We assessed wall thickness (WT), total wall area (TWA), lumen diameter, and total nuclei number/cross-section (TN) in cirrhotic rats with ascites and in control rats. A second group of cirrhotic rats received the NO synthesis inhibitor, L-NAME, or vehicle daily for 11 weeks and systemic hemodynamics, arterial compliance, aortic NO synthase 3 (NOS3) protein expression, and vascular morphology were analyzed. Cirrhotic vessels showed a significant reduction in WT, TWA, and TN as compared to control vessels. Long-term inhibition of NOS activity in cirrhotic rats resulted in a significant increase in WT, TWA, and TN as compared to cirrhotic rats receiving vehicle. NOS3 protein abundance was higher in aortic vessels of nontreated cirrhotic animals than in controls. This difference was abolished by chronic treatment with L-NAME. NOS inhibition in cirrhotic rats resulted in higher arterial pressure and peripheral resistance and lower arterial compliance than cirrhotic rats receiving vehicle. Therefore, vascular remodeling in cirrhosis with ascites is a generalized process with significant functional consequences that can be negatively modulated by long-term inhibition of NOS activity.




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