help button home button Am J Pathol Epitomics, Inc.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Related articles in Am J Pathol
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Richter, H.
Right arrow Articles by Zitzelsberger, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richter, H.
Right arrow Articles by Zitzelsberger, H.
(American Journal of Pathology. 2003;163:287-294.)
© 2003 American Society for Investigative Pathology

Distinct Chromosomal Imbalances in Nonpolypoid and Polypoid Colorectal Adenomas Indicate Different Genetic Pathways in the Development of Colorectal Neoplasms

Hedwig Richter*, Premysl Slezak{dagger}, Axel Walch{ddagger}, Martin Werner{ddagger}, Herbert Braselmann*, Edgar Jaramillo§, Åke Öst, Ichiro Hirata||, Kazuya Takahama** and Horst Zitzelsberger*

From the Institute of Molecular Radiobiology,*GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Neuherberg, Germany; the Institute of Pathology,{ddagger} Universtätsklinikum Freiburg, Freiburg, Germany; the Department of Gastroenterology and Hepatology,§ Endoscopy Unit, Karolinska Hospital, Stockholm, Sweden; the Department of Pathology and Cytology, Medilab and Karolinska Institute, Stockholm, Sweden; the Department II of Internal Medicine,|| Osaka Medical College and Hospital, Takatsuki City, Osaka, Japan; the Department of Internal Medicine,** Fujita Health University, Toyota, Aichi, Japan; and the Department of Gastroenterology and Hepatology,{dagger} Karolinska Hospital, and Karolinska Institute, Stockholm, Sweden

Cytogenetic changes are widely unknown for nonpolypoid (synonymously termed as "flat" or "depressed") colorectal adenomas. A comparison with polypoid adenomas will contribute to the discussion whether different genetic pathways for colorectal tumorigenesis depending on its origin from nonpolypoid or polypoid adenomas exist. Tissue samples of nonpolypoid (n = 22), polypoid (n = 28) adenomas, carcinomas ex-nonpolypoid adenomas (n = 9), carcinomas ex-polypoid adenomas (n = 14), and normal colonic mucosa (n = 9) were investigated by comparative genomic hybridization of whole genomic DNA. Chromosomal imbalances were detected from average comparative genomic hybridization profiles for each entity. Nonpolypoid adenomas show recurrent chromosomal losses on chromosomes 16, 17p, 18, 20, and 22 and gains on chromosomes 2q, 4q, 5, 6, 8q, 12q, and 13q. In polypoid adenomas losses of whole chromosomes 16, 18, and 22 and gains of chromosomes 7q and 13 were detected. The frequency of copy number changes was higher in nonpolypoid compared to polypoid adenomas and early onset of chromosomal changes became apparent in low-grade dysplasias of nonpolypoid adenomas. Gains on chromosomes 2q, 5, 6, 8q, and 12q and losses on chromosomes 17p and 20 occurred exclusively in nonpolypoid adenomas, whereas 16p deletions are significantly more frequent in nonpolypoid than in polypoid adenomas. Carcinomas ex-nonpolypoid adenomas are characterized by more complex aberration patterns compared to nonpolypoid adenomas exhibiting frequent losses on chromosomes 8p, 12q, 14, 15q, 16, 17p, 18, and 22 and gains on 3q, 5, 6, 7, 8q, 12q, and 13, respectively. Normal colonic mucosa showed no chromosomal imbalances. Distinct differences of chromosomal imbalances between nonpolypoid and polypoid colorectal adenomas have been characterized that support the hypothesis that different genetic pathways may exist in the development of colorectal adenomas exhibiting nonpolypoid and polypoid phenotype.


Related articles in Am J Pathol:

This Month in AJP

Am J Pathol 2003 163: 1-2. [Full Text]  



This article has been cited by other articles:


Home page
 Am J Clin PatholHome page
G.-Z. Meng, H.-Y. Zhang, Z. Zhang, B. Wei, and H. Bu
Myofibroblastic Sarcoma vs Nodular Fasciitis: A Comparative Study of Chromosomal Imbalances
Am J Clin Pathol, May 1, 2009; 131(5): 701 - 709.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the American Society for Investigative Pathology.