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(American Journal of Pathology. 2003;163:563-570.)
© 2003 American Society for Investigative Pathology

Mitogenic Properties of Endogenous and Pharmacological Doses of Macrophage Inflammatory Protein-2 after 70% Hepatectomy in the Mouse

Xiaodan Ren*, Audra Carpenter*, Cory Hogaboam{dagger} and Lisa Colletti*

From the Departments of Surgery* and Pathology,{dagger} University of Michigan Medical School, Ann Arbor, Michigan

Recent studies show CXC chemokine elevations after hepatic resection; blockade of epithelial neutrophil-activating protein (ENA-78), a CXC chemokine, retards hepatic regeneration after resection. Additional studies demonstrate that exogenous macrophage inflammatory protein (MIP)-2, another CXC chemokine, is therapeutic in a murine acetaminophen toxicity model when other therapies fail. The current investigations study MIP-2’s effects on the cellular mechanisms involved in liver regeneration in mice after 70% hepatectomy. Administration of exogenous MIP-2 after 70% hepatectomy dramatically increased hepatocyte proliferation as measured by 5-bromo-2'-deoxyuridine staining. Signal transducer and activator of transcription-3 (stat-3) was also detected in greater abundance and persisted in hepatic nuclear extracts from MIP-2-treated mice compared with control mice after hepatic resection. Further, inhibition of the MIP-2 receptor, CXCR2, decreased baseline hepatocyte proliferation and stat-3 expression in the setting of partial hepatectomy. These data show that MIP-2 is important for hepatocyte proliferation after partial hepatectomy and that pharmacological MIP-2 doses after hepatic injury accelerate hepatic regeneration.




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