help button home button Am J Pathol ASIP WHAT IS IT?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ren, X.
Right arrow Articles by Colletti, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ren, X.
Right arrow Articles by Colletti, L.
(American Journal of Pathology. 2003;163:563-570.)
© 2003 American Society for Investigative Pathology

Mitogenic Properties of Endogenous and Pharmacological Doses of Macrophage Inflammatory Protein-2 after 70% Hepatectomy in the Mouse

Xiaodan Ren*, Audra Carpenter*, Cory Hogaboam{dagger} and Lisa Colletti*

From the Departments of Surgery* and Pathology,{dagger} University of Michigan Medical School, Ann Arbor, Michigan

Recent studies show CXC chemokine elevations after hepatic resection; blockade of epithelial neutrophil-activating protein (ENA-78), a CXC chemokine, retards hepatic regeneration after resection. Additional studies demonstrate that exogenous macrophage inflammatory protein (MIP)-2, another CXC chemokine, is therapeutic in a murine acetaminophen toxicity model when other therapies fail. The current investigations study MIP-2’s effects on the cellular mechanisms involved in liver regeneration in mice after 70% hepatectomy. Administration of exogenous MIP-2 after 70% hepatectomy dramatically increased hepatocyte proliferation as measured by 5-bromo-2'-deoxyuridine staining. Signal transducer and activator of transcription-3 (stat-3) was also detected in greater abundance and persisted in hepatic nuclear extracts from MIP-2-treated mice compared with control mice after hepatic resection. Further, inhibition of the MIP-2 receptor, CXCR2, decreased baseline hepatocyte proliferation and stat-3 expression in the setting of partial hepatectomy. These data show that MIP-2 is important for hepatocyte proliferation after partial hepatectomy and that pharmacological MIP-2 doses after hepatic injury accelerate hepatic regeneration.




This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
O. Kollmar, C. Scheuer, M. D. Menger, and M. K. Schilling
Macrophage Inflammatory Protein-2 Promotes Angiogenesis, Cell Migration, and Tumor Growth in Hepatic Metastasis
Ann. Surg. Oncol., February 1, 2006; 13(2): 263 - 275.
[Abstract] [Full Text] [PDF]

Home page
 J Clin PharmacolHome page
L. P. James, P. M. Simpson, H. C. Farrar, G. L. Kearns, G. S. Wasserman, J. L. Blumer, M. D. Reed, J. E. Sullivan, J. A. Hinson, and The Pediatric Pharmacology Research Unit Network
Cytokines and Toxicity in Acetaminophen Overdose
J. Clin. Pharmacol., October 1, 2005; 45(10): 1165 - 1171.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the American Society for Investigative Pathology.