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(American Journal of Pathology. 2003;163:1215-1226.)
© 2003 American Society for Investigative Pathology

Review

T-Cell-Mediated Autoimmunity

Novel Techniques to Characterize Autoreactive T-Cell Receptors

Klaus Dornmair*{dagger}, Norbert Goebels{dagger}, Hans-Ulrich Weltzien{ddagger}, Hartmut Wekerle* and Reinhard Hohlfeld*{dagger}

From the Max-Planck Institute of Neurobiology,* Martinsried; the Institute for Clinical Neuroimmunology,{dagger} Klinikum Großhadern, Ludwig Maximilians University, Munich; Max-Planck-Institute for Immunobiology,{ddagger} Freiburg, Germany

Abstract

Histological samples of autopsy or biopsy tissue provide the best available evidence that autoreactive T cells are involved in the immunopathogenesis of many autoimmune diseases. However, morphology alone does not provide information on the antigen-specific T-cell receptor (TCR) of these cells, let alone on their antigen specificity. In this review article we discuss a number of emerging possibilities for identifying TCR sequences directly from biopsy tissue. We also review the methods for expressing presumably autoreactive TCR molecules and speculate on how the expressed TCR might be used to identify target antigens. Such information should eventually provide new insights into disease pathogenesis which lead to better therapies.




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Copyright © 2003 by the American Society for Investigative Pathology.