help button home button Am J Pathol Epitomics, Inc.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Skotheim, R. I.
Right arrow Articles by Saatcioglu, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Skotheim, R. I.
Right arrow Articles by Saatcioglu, F.
(American Journal of Pathology. 2003;163:2149-2154.)
© 2003 American Society for Investigative Pathology

Short Communication

NKX3.1 Expression Is Lost in Testicular Germ Cell Tumors

Rolf I. Skotheim*, Kemal S. Korkmaz{dagger}, Tove I. Klokk{dagger}, Vera M. Abeler{ddagger}, Ceren G. Korkmaz{dagger}, Jahn M. Nesland{ddagger}, Sophie D. Fosså§, Ragnhild A. Lothe*{dagger} and Fahri Saatcioglu{dagger}

From the Department of Genetics,* Institute for Cancer Research, and the Departments of Pathology{ddagger} and Medical Oncology and Radiotherapy,§ The Norwegian Radium Hospital and University of Oslo, Oslo; and the Department of Cell and Molecular Biology,{dagger} Institute of Biology, University of Oslo, Oslo, Norway

NKX3.1 is a homeobox gene which exhibits prostate and testis specific expression. Loss of NKX3.1 expression has been implicated in prostate development and tumorigenesis, but the role of NKX3.1 in testis biology is not known. Here we show that NKX3.1 expression is dramatically down-regulated in testicular cancer of germ cell origin. Immunohistochemical analysis on a tissue microarray containing 510 testicular tissue samples indicate that NKX3.1 is expressed at high levels in normal germ cells and in carcinoma in situ, but is sharply decreased or absent in most seminomas and all embryonal carcinomas. However, NKX3.1 is expressed in a subset of the more differentiated nonseminomas. We provide evidence that these changes in NKX3.1 protein levels are mainly due to transcriptional effects. These results suggest that NKX3.1 is essential for normal testis function and that its loss of expression is highly associated with the invasive phenotype of testicular germ cell tumors.




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
S. R. Payne and C. J. Kemp
Tumor suppressor genetics
Carcinogenesis, December 1, 2005; 26(12): 2031 - 2045.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the American Society for Investigative Pathology.