| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
From the Department of Microbiology, Immunology, and Molecular Genetics,* Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas; the Department of Neurology, The Johns Hopkins University, Baltimore, Maryland; and the Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Inflammatory mediators play a crucial role in the pathophysiology of several neurodegenerative diseases including acquired immune deficiency syndrome dementia complex. In the present study we identified a link between CXCL10 overexpression in the brain and human immunodeficiency virus dementia and demonstrated the presence of the chemokine CXCL10 and its receptor, CXCR3, in the neurons in the brains of macaques with simian human immunodeficiency virus encephalitis. Using human fetal brain cultures, we showed that treatment of these cells with either SHIV89.6P or viral gp120 resulted in induction of CXCL10 in neurons. Cultured neurons treated with the chemokine developed increased membrane permeability followed by apoptosis via activation of caspase-3. We confirmed the relevance of these findings in sections of human and macaque brains with encephalopathy demonstrating that neurons expressing CXCL10 also expressed caspase-3.
This article has been cited by other articles:
 |
|
 |
|
  G. S. V. Campanella, A. M. Tager, J. K. El Khoury, S. Y. Thomas, T. A. Abrazinski, L. A. Manice, R. A. Colvin, and A. D. Luster Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria PNAS, March 25, 2008; 105(12): 4814 - 4819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. van Marle, J. Antony, H. Ostermann, C. Dunham, T. Hunt, W. Halliday, F. Maingat, M. D. Urbanowski, T. Hobman, J. Peeling, et al. West Nile Virus-Induced Neuroinflammation: Glial Infection and Capsid Protein-Mediated Neurovirulence J. Virol., October 15, 2007; 81(20): 10933 - 10949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Dhillon, F. Peng, R. M. Ransohoff, and S. Buch PDGF Synergistically Enhances IFN-{gamma}-Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV Dementia J. Immunol., September 1, 2007; 179(5): 2722 - 2730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Dhillon, D. Pinson, S. Dhillon, O. Tawfik, M. Danley, M. Davis, O. Nemon, M. Mayo, A. Kumar, Y.-J. Tsai, et al. Bleomycin treatment causes enhancement of virus replication in the lungs of SHIV-infected macaques Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1233 - L1240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Klein, E. Lin, B. Zhang, A. D. Luster, J. Tollett, M. A. Samuel, M. Engle, and M. S. Diamond Neuronal CXCL10 Directs CD8+ T-Cell Recruitment and Control of West Nile Virus Encephalitis J. Virol., September 1, 2005; 79(17): 11457 - 11466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. de Jong, I. M. Dijkstra, M. Hensens, N. Brouwer, M. van Amerongen, R. S. B. Liem, H. W. G. M. Boddeke, and K. Biber Vesicle-Mediated Transport and Release of CCL21 in Endangered Neurons: A Possible Explanation for Microglia Activation Remote from a Primary Lesion J. Neurosci., August 17, 2005; 25(33): 7548 - 7557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sui, S. Li, D. Pinson, I. Adany, Z. Li, F. Villinger, O. Narayan, and S. Buch Simian Human Immunodeficiency Virus-Associated Pneumonia Correlates with Increased Expression of MCP-1, CXCL10, and Viral RNA in the Lungs of Rhesus Macaques Am. J. Pathol., February 1, 2005; 166(2): 355 - 365. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
