| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
From the Center for Neurologic Diseases,* Brigham and Women’s Hospital, Harvard Medical School, Boston; Transplantation Research Center, Brigham and Women’s Hospital, and Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts; and The Burnham Institute, Program in Developmental and Regenerative Cell Biology, La Jolla, California
Increased expression of the costimulatory molecule CD80 (B7–1) was noted in the subventricular zone of the brain during the course of experimental autoimmune encephalomyelitis (EAE). This area of the brain is a neural stem cell (NSC) niche in the adult. We show that isolated NSCs from adult brain express CD80 and CD86 (B7–2) and this expression is increased after exposure to IFN-
or TNF-
, the prototypical Th1 cytokines expressed during EAE. CD80 and CD86 expressed by NSCs are functional and can costimulate allogeneic cells in a mixed lymphocyte reaction. Furthermore, cross-linking of CD80 on the surface of NSCs results in apoptosis of NSCs. In vitro, we show that T cells can interact with NSCs and form conjugates with redistribution of CD3 on the surface of T cells to the area of contact. These data raise the possibility that during CNS inflammatory diseases such as EAE, NSCs may express immune molecules and interact with the inflammatory environment potentially resulting in injury to the NSCs, which may have implications for repair mechanisms in the central nervous system.
This article has been cited by other articles:
 |
|
 |
|
  S.-T. Lee, K. Chu, K.-H. Jung, and J.-K. Roh Response to 'The pulmonary first-pass effect, xenotransplantation and translation to clinical trials' Brain, July 10, 2008; (2008) awn143v1. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Chen and T. D. Palmer Cellular repair of CNS disorders: an immunological perspective Hum. Mol. Genet., April 15, 2008; 17(R1): R84 - R92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ubiali, S. Nava, V. Nessi, S. Frigerio, E. Parati, P. Bernasconi, R. Mantegazza, and F. Baggi Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-{beta} in modulating proliferation Int. Immunol., September 1, 2007; 19(9): 1063 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. Szotek, H. L. Chang, L. Zhang, F. Preffer, D. Dombkowski, P. K. Donahoe, and J. Teixeira Adult Mouse Myometrial Label-Retaining Cells Divide in Response to Gonadotropin Stimulation Stem Cells, May 1, 2007; 25(5): 1317 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-E. Kim, K. Tsuji, Y. R. Kim, F.-J. Mueller, H.-S. Eom, E. Y. Snyder, E. H. Lo, R. Weissleder, and D. Schellingerhout Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging Radiology, December 1, 2006; 241(3): 822 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Imitola, K. Raddassi, K. I. Park, F.-J. Mueller, M. Nieto, Y. D. Teng, D. Frenkel, J. Li, R. L. Sidman, C. A. Walsh, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1{alpha}/CXC chemokine receptor 4 pathway PNAS, December 28, 2004; 101(52): 18117 - 18122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ruffini, T. E. Kennedy, and J. P. Antel Inflammation and Remyelination in the Central Nervous System: A Tale of Two Systems Am. J. Pathol., May 1, 2004; 164(5): 1519 - 1522. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
