help button home button Am J Pathol Epitomics Buy 2 Antibodies Get 1 Free Special Offer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Antonov, A. S.
Right arrow Articles by Gerrity, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Antonov, A. S.
Right arrow Articles by Gerrity, R. G.
(American Journal of Pathology. 2004;165:247-258.)
© 2004 American Society for Investigative Pathology

Regulation of Macrophage Foam Cell Formation by {alpha}Vß3 Integrin

Potential Role in Human Atherosclerosis

Alexander S. Antonov*, Frank D. Kolodgie{dagger}, David H. Munn{ddagger} and Ross G. Gerrity*

From the Department of Pathology* and Institute of Molecular Medicine and Genetics,{ddagger} Medical College of Georgia, Augusta, Georgia; and the Armed Forces Institute of Pathology,{dagger} Washington, DC

The accumulation of macrophage foam cells in atherosclerotic lesions is associated with both initiation and progression of this disease. Scavenger receptors CD36 and SRA are the primary receptors responsible for conversion of macrophages into foam cells. Integrin {alpha}Vß3 plays a role in the differentiation of several cell types, but its involvement in the transition of macrophages into foam cells and the potential role of this receptor in atherosclerosis have not been examined. Using an in vitro model of single surface receptor activation by binding with an immobilized monoclonal antibody specific to {alpha}Vß3 integrin we show that ligation of {alpha}Vß3 integrin prevents differentiation of blood monocytes and macrophages into the foam cell phenotype via coordinate down-regulation of CD36 and SRA. This effect of {alpha}Vß3 integrin ligation can be reproduced by contact with endothelial cells, whereas the inhibition of {alpha}Vß3 receptor ligation restores the uptake of oxidized low-density lipoprotein. Moreover, we found that {alpha}Vß3 integrin is readily detected in situ on macrophages in early and advanced atherosclerotic lesions and that in vitro exposure to oxidized low-density lipoprotein up-regulates {alpha}Vß3 integrin expression. We hypothesize that {alpha}Vß3 integrin regulates macrophage functional maturation into foam cells in a persistent manner, and therefore, by targeting {alpha}Vß3 receptor it could potentially be possible to regulate progression of atherosclerosis in humans.




This article has been cited by other articles:


Home page
 CirculationHome page
A. Handberg, K. Levin, K. Hojlund, and H. Beck-Nielsen
Identification of the Oxidized Low-Density Lipoprotein Scavenger Receptor CD36 in Plasma: A Novel Marker of Insulin Resistance
Circulation, September 12, 2006; 114(11): 1169 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Khurana, M. Simons, J. F. Martin, and I. C. Zachary
Role of Angiogenesis in Cardiovascular Disease: A Critical Appraisal
Circulation, September 20, 2005; 112(12): 1813 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. Schapira, E. Lutgens, A. de Fougerolles, A. Sprague, A. Roemen, H. Gardner, V. Koteliansky, M. Daemen, and S. Heeneman
Genetic Deletion or Antibody Blockade of {alpha}1{beta}1 Integrin Induces a Stable Plaque Phenotype in ApoE-/- Mice
Arterioscler. Thromb. Vasc. Biol., September 1, 2005; 25(9): 1917 - 1924.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Q. Cai, L. Lanting, and R. Natarajan
Interaction of Monocytes With Vascular Smooth Muscle Cells Regulates Monocyte Survival and Differentiation Through Distinct Pathways
Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2263 - 2270.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American Society for Investigative Pathology.