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(American Journal of Pathology. 2004;165:753-761.)
© 2004 American Society for Investigative Pathology

The Impact of Cyclooxygenase-2 Mediated Inflammation on Scarless Fetal Wound Healing

Traci A. Wilgus*, Valerie K. Bergdall{dagger}, Kathleen L. Tober*, Kara J. Hill*, Srabani Mitra{ddagger}, Nicholas A. Flavahan{ddagger} and Tatiana M. Oberyszyn*

From the Departments of Pathology,* Veterinary Preventive Medicine/University Laboratory Animal Resources,{dagger} and Heart and Lung Research Institute,{ddagger} The Ohio State University, Columbus, Ohio

Cyclooxygenase-2 (COX-2) and the prostaglandin products generated as a result of COX-2 activity mediate a variety of biological and pathological processes. Scarless healing occurs in fetal skin in the first and second trimesters of development. This scarless healing process is known to proceed without a significant inflammatory response, which appears to be important for the lack of scarring. Because the COX-2 pathway is an integral component of inflammation, we investigated its role in the fetal repair process using a mouse model of scarless fetal wound healing. COX-2 expression in scarless and fibrotic fetal wounds was examined. In addition, the ability of exogenous prostaglandin E2 to alter scarless fetal healing was evaluated. The results suggest that the COX-2 pathway is involved in scar production in fetal skin and that targeting COX-2 may be useful for limiting scar formation in adult skin.




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Copyright © 2004 by the American Society for Investigative Pathology.