| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
From the Department of Pathology* and the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Blood neutrophils (PMN) are usually unresponsive to CC chemokines such as monacyte chemotactic protein-1 and macrophage inflammatory protein-1
. In rodents, the lung buildup of PMN as determined by myeloperoxidase (MPO) activity after airway instillation of bacterial lipopolysaccharide (LPS) was independent of MCP-1 and MIP-1. In striking contrast, during sepsis following cecal ligation and puncture (CLP), blood PMN demonstrated mRNA for CC chemokine receptors. Furthermore, PMN from CLP, but not from sham rodents, bound MCP-1 and MIP-1 and responded chemotactically in vitro to both MCP-1 and MIP-1. In CCR2–/– mice or WT mice treated in vivo with antibodies to either MCP-1 or MIP-1, MPO activity was greatly attenuated in CLP animals. In CLP mice, increased serum IL-6 levels were found to be dependent on CCR2, MCP-1, and MIP-1. When PMN from CLP rodents were incubated in vitro with either MCP-1 or MIP-1, release of IL-6 was also shown. These findings suggest that sepsis fundamentally alters the trafficking of PMN into the lung in a manner that now engages functional responses to CC chemokines.
This article has been cited by other articles:
 |
|
 |
|
  S. B. Flohe, S. Flohe, and F. U. Schade Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms Innate Immunity, December 1, 2008; 14(6): 333 - 344. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Hartl, S. Krauss-Etschmann, B. Koller, P. L. Hordijk, T. W. Kuijpers, F. Hoffmann, A. Hector, E. Eber, V. Marcos, I. Bittmann, et al. Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases J. Immunol., December 1, 2008; 181(11): 8053 - 8067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Uozumi, Y. Kita, and T. Shimizu Modulation of Lipid and Protein Mediators of Inflammation by Cytosolic Phospholipase A2{alpha} during Experimental Sepsis J. Immunol., September 1, 2008; 181(5): 3558 - 3566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Hsieh, M. Frink, Y.-C. Hsieh, W.-H. Kan, J.-T. Hsu, M. G. Schwacha, M. A. Choudhry, and I. H. Chaudry The Role of MIP-1{alpha} in the Development of Systemic Inflammatory Response and Organ Injury following Trauma Hemorrhage J. Immunol., August 15, 2008; 181(4): 2806 - 2812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rittirsch, M. A. Flierl, D. E. Day, B. A. Nadeau, S. R. McGuire, L. M. Hoesel, K. Ipaktchi, F. S. Zetoune, J. V. Sarma, L. Leng, et al. Acute Lung Injury Induced by Lipopolysaccharide Is Independent of Complement Activation J. Immunol., June 1, 2008; 180(11): 7664 - 7672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sun, R. D. Ramnath, and M. Bhatia Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils Am J Physiol Cell Physiol, August 1, 2007; 293(2): C696 - C704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. He, R. Horuk, S. M. Moochhala, and M. Bhatia Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1173 - G1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Wareing, A. Lyon, C. Inglis, F. Giannoni, I. Charo, and S. R. Sarawar Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2-/- mice J. Leukoc. Biol., March 1, 2007; 81(3): 793 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Frink, A. Lu, B. M. Thobe, Y.-C. Hsieh, M. A. Choudhry, M. G. Schwacha, S. L. Kunkel, and I. H. Chaudry Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1110 - R1116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Dessing, A. F. de Vos, S. Florquin, and T. van der Poll Monocyte Chemoattractant Protein 1 Does Not Contribute to Protective Immunity against Pneumococcal Pneumonia Infect. Immun., December 1, 2006; 74(12): 7021 - 7023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hildebrand, W. J. Hubbard, M. A. Choudhry, B. M. Thobe, H.-C. Pape, and I. H. Chaudry Effects of 17{beta}-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females J. Leukoc. Biol., October 1, 2006; 80(4): 759 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hildebrand, W. J. Hubbard, M. A. Choudhry, M. Frink, H.-C. Pape, S. L. Kunkel, and I. H. Chaudry Kupffer Cells and Their Mediators: The Culprits in Producing Distant Organ Damage after Trauma-Hemorrhage Am. J. Pathol., September 1, 2006; 169(3): 784 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, M. Arora, M. Yarlagadda, T. B. Oriss, N. Krishnamoorthy, A. Ray, and P. Ray Distinct Responses of Lung and Spleen Dendritic Cells to the TLR9 Agonist CpG Oligodeoxynucleotide J. Immunol., August 15, 2006; 177(4): 2373 - 2383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Puneet, A. Hegde, S. W. Ng, H. Y. Lau, J. Lu, S. M. Moochhala, and M. Bhatia Preprotachykinin-A Gene Products Are Key Mediators of Lung Injury in Polymicrobial Sepsis J. Immunol., March 15, 2006; 176(6): 3813 - 3820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Reichel, A. Khandoga, H.-J. Anders, D. Schlondorff, B. Luckow, and F. Krombach Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue J. Leukoc. Biol., January 1, 2006; 79(1): 114 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Jones, B. T. Simms, M. M. Lupa, M. S. Kogan, and J. P. Mizgerd Lung NF-{kappa}B Activation and Neutrophil Recruitment Require IL-1 and TNF Receptor Signaling during Pneumococcal Pneumonia J. Immunol., December 1, 2005; 175(11): 7530 - 7535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Iida, T. Kohro, T. Kodama, S. Nagata, and R. Fukunaga Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic differentiation J. Leukoc. Biol., August 1, 2005; 78(2): 481 - 490. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
