help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oh, B.-K.
Right arrow Articles by Park, Y. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oh, B.-K.
Right arrow Articles by Park, Y. N.
(American Journal of Pathology. 2005;166:73-80.)
© 2005 American Society for Investigative Pathology

Up-Regulation of Telomere-Binding Proteins, TRF1, TRF2, and TIN2 Is Related to Telomere Shortening during Human Multistep Hepatocarcinogenesis

Bong-Kyeong Oh*, Young-Joo Kim*, Chanil Park*{dagger} and Young Nyun Park*{dagger}

From the Department of Pathology,*Center for Chronic Metabolic Disease Research and Brain Korea 21 Project for Medical Science, and the Institute of Gastroenterology,{dagger} Yonsei University College of Medicine, Seoul, Korea

The telomeric repeat-binding factor 1 (TRF1), TRF2, and the TRF1-interacting nuclear protein 2 (TIN2) are involved in telomere maintenance. We describe the regulation of expression of these genes along with their relationship to telomere length in hepatocarcinogenesis. The transcriptional expression of these genes, TRF1 protein, and telomere length was examined in 9 normal livers, 14 chronic hepatitis, 24 liver cirrhosis, 5 large regenerative nodules, 14 low-grade dysplastic nodules (DNs), 7 high-grade DNs, 10 DNs with hepatocellular carcinoma (HCC) foci, and 31 HCCs. The expression of TRF1, TRF2, TIN2 mRNA, and TRF1 protein was gradually increased according to the progression of hepatocarcinogenesis with a marked increase in high-grade DNs and DNs with HCC foci and a further increase in HCCs. There was a gradual shortening of telomere during hepatocarcinogenesis with a significant reduction in length in DNs. Most nodular lesions (52 of 67) had shorter telomeres than their adjacent chronic hepatitis or liver cirrhosis, and the telomere lengths were inversely correlated with the mRNA level of these genes (P ≤ 0.001). This was more evident in DNs and DNs with HCC foci. In conclusion, TRF1, TRF2, and TIN2 might be involved in multistep hepatocarcinogenesis by playing crucial roles in telomere shortening.




This article has been cited by other articles:


Home page
 J. Cell Biol.Home page
M. Stagno D'Alcontres, A. Mendez-Bermudez, J. L. Foxon, N. J. Royle, and P. Salomoni
Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA
J. Cell Biol., December 3, 2007; 179(5): 855 - 867.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
R. Blanco, P. Munoz, J. M. Flores, P. Klatt, and M. A. Blasco
Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis
Genes & Dev., January 15, 2007; 21(2): 206 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
X. Lin, J. Gu, C. Lu, M. R. Spitz, and X. Wu
Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer.
Clin. Cancer Res., October 1, 2006; 12(19): 5720 - 5725.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
N H Park, I H Song, and Y-H Chung
Chronic hepatitis B in hepatocarcinogenesis.
Postgrad. Med. J., August 1, 2006; 82(970): 507 - 515.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American Society for Investigative Pathology.