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(American Journal of Pathology. 2005;166:783-792.)
© 2005 American Society for Investigative Pathology

The Plasminogen Activator/Plasmin System Is Essential for Development of the Joint Inflammatory Phase of Collagen Type II-Induced Arthritis

Jinan Li*, Annelii Ny*, Göran Leonardsson*, Kutty Selva Nandakumar{dagger}, Rikard Holmdahl{dagger} and Tor Ny*

From the Department of Medical Biochemistry and Biophysics,* Umeå University, Umeå; and the Section for Medical Inflammation Research,{dagger} Lund University, Lund, Sweden

The plasminogen activator (PA) system has been proposed to have important roles in rheumatoid arthritis. Here we have used the autoimmune collagen type II (CII)-induced arthritis (CIA) model and mice deficient for urokinase-type PA (uPA) or plasminogen to investigate the role of the PA system for development of arthritis. Our data revealed that uPA-deficient mice have a lower severity and incidence of CIA than wild-type mice. Furthermore, although >80% of wild-type control mice developed CIA, we found that none of the 50 plasminogen-deficient littermates that were tested developed CIA within a 40-day period. Antibody generation after CII immunization as well as the binding of labeled anti-CII antibodies to the surface of cartilage were similar in wild-type and plasminogen-deficient mice. No sign of inflammation was seen when plasminogen-deficient mice were injected with a mixture of monoclonal antibodies against CII. However, after daily injections of human plasminogen, these mice developed arthritis within 5 days. Our finding that infiltration of inflammatory cells into the synovial joints was impaired in plasminogen-deficient mice suggests that uPA and plasminogen are important mediators of joint inflammation. Active plasmin is therefore essential for the induction of pathological inflammatory joint destruction in CIA.




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M. O. Judex and B. M. Mueller
Plasminogen Activation/Plasmin in Rheumatoid Arthritis: Matrix Degradation and More
Am. J. Pathol., March 1, 2005; 166(3): 645 - 647.
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