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(American Journal of Pathology. 2005;166:1691-1699.)
© 2005 American Society for Investigative Pathology

Inflammation and Extracellular Matrix Degradation Mediated by Activated Transcription Factors Nuclear Factor-B and Activator Protein-1 in Inflammatory Acne Lesions in Vivo

From the Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan

Acne is the most common skin disease, causing significant psychosocial problems for those afflicted. Currently available agents for acne treatment, such as oral antibiotics and isotretinoin (Accutane), have limited use. Thus, development of novel agents to treat this disease is needed. However, the pathophysiology of acne inflammation is poorly understood. Before new therapeutic strategies can be devised, knowledge regarding molecular mechanisms of acne inflammation is required. We report here that transcription factors nuclear factor-B and activator protein-1 are activated in acne lesions with consequent elevated expression of their target gene products, inflammatory cytokines and matrix-degrading metalloproteinases, respectively. These elevated gene products are molecular mediators of inflammation and collagen degradation in acne lesions in vivo. This new knowledge enables a rational strategy for development of pharmacological agents that can target the inflammation and matrix remodeling that occurs in severe acne.

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